Placebo Effect in Obsessive-Compulsive Disorder (OCD). Placebo Response and Placebo Responders in OCD: The Trend Over Time.
Obsessive-compulsive disorder
placebo effect
placebo response
publication year.
Journal
Current neuropharmacology
ISSN: 1875-6190
Titre abrégé: Curr Neuropharmacol
Pays: United Arab Emirates
ID NLM: 101157239
Informations de publication
Date de publication:
2019
2019
Historique:
received:
25
05
2018
revised:
16
07
2018
accepted:
17
10
2018
pubmed:
30
10
2018
medline:
16
1
2020
entrez:
30
10
2018
Statut:
ppublish
Résumé
Placebo response appears to be increasing in antidepressant, antipsychotic and various internal medicine trials. A similar trend has been reported for OCD during 1989-1999. Placebo response is generally considered as the extent to which placebo treatment is associated with core symptom improvement. In this analysis, we used Joinpoint regression to assess the time trend of both placebo response and placebo responder rates according to the year of publication with no time restriction in OCD drug trials. We included drug and/or psychotherapy trials vs. placebo from PubMed, Embase, CINAHL, and PsycINFO retrieved through the search (placebo OR sham) AND (obsessive* OR OCD). We included studies through investigator consensus. We then performed on data of included studies log-linear joinpoint segmented regression models using a p<0.05 cutoff. We included 113 studies from 112 published papers. Placebo mean annual response rates in OCD studies significantly increased from 1991 to 2017 with an annual percent change (APC) of 0.66%, while placebo mean annual responder rates also significantly increased from 2010 to 2017, with an APC of 5.45%. Drug mean annual response rates in OCD studies significantly increased from 1987 to 2012 with an APC of 0.72%, while the corresponding responder rates did not show statistically significant APC changes between 1984 and 2017. We observed a tendency for placebo to increase both measures of response in OCD clinical drug trials through the years that tend to approximate the responses shown by drugs. Changes in the type of study (moving from classical head to head comparisons to add-on studies in treatmentresistant populations) and countries involved in experimentation may partially account for some portion of these results. It appears that placebo effects are becoming more elusive and out of control.
Sections du résumé
BACKGROUND
BACKGROUND
Placebo response appears to be increasing in antidepressant, antipsychotic and various internal medicine trials. A similar trend has been reported for OCD during 1989-1999. Placebo response is generally considered as the extent to which placebo treatment is associated with core symptom improvement. In this analysis, we used Joinpoint regression to assess the time trend of both placebo response and placebo responder rates according to the year of publication with no time restriction in OCD drug trials.
METHODS
METHODS
We included drug and/or psychotherapy trials vs. placebo from PubMed, Embase, CINAHL, and PsycINFO retrieved through the search (placebo OR sham) AND (obsessive* OR OCD). We included studies through investigator consensus. We then performed on data of included studies log-linear joinpoint segmented regression models using a p<0.05 cutoff.
RESULTS
RESULTS
We included 113 studies from 112 published papers. Placebo mean annual response rates in OCD studies significantly increased from 1991 to 2017 with an annual percent change (APC) of 0.66%, while placebo mean annual responder rates also significantly increased from 2010 to 2017, with an APC of 5.45%. Drug mean annual response rates in OCD studies significantly increased from 1987 to 2012 with an APC of 0.72%, while the corresponding responder rates did not show statistically significant APC changes between 1984 and 2017.
CONCLUSION
CONCLUSIONS
We observed a tendency for placebo to increase both measures of response in OCD clinical drug trials through the years that tend to approximate the responses shown by drugs. Changes in the type of study (moving from classical head to head comparisons to add-on studies in treatmentresistant populations) and countries involved in experimentation may partially account for some portion of these results. It appears that placebo effects are becoming more elusive and out of control.
Identifiants
pubmed: 30370851
pii: CN-EPUB-94037
doi: 10.2174/1570159X16666181026163922
pmc: PMC7059157
doi:
Substances chimiques
Antidepressive Agents
0
Antipsychotic Agents
0
Serotonin Uptake Inhibitors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
741-774Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Références
Arch Gen Psychiatry. 1998 Oct;55(10):918-24
pubmed: 9783563
J Clin Epidemiol. 2000 Aug;53(8):786-92
pubmed: 10942860
J Am Acad Child Adolesc Psychiatry. 1992 Jan;31(1):45-9
pubmed: 1537780
Pain. 2015 Dec;156(12):2616-26
pubmed: 26307858
J Clin Pharm Ther. 2016 Apr;41(2):214-9
pubmed: 26931055
Int Clin Psychopharmacol. 2001 Mar;16(2):75-86
pubmed: 11236072
J Psychiatr Res. 2009 Mar;43(6):664-70
pubmed: 19046587
JAMA. 1998 Nov 25;280(20):1752-6
pubmed: 9842950
Biol Psychiatry. 2004 Mar 1;55(5):553-5
pubmed: 15023585
J Clin Psychopharmacol. 2002 Jun;22(3):309-17
pubmed: 12006902
J Psychiatr Res. 2017 Nov;94:23-28
pubmed: 28647677
J Psychiatr Res. 2016 Sep;80:30-37
pubmed: 27281260
Psychopharmacology (Berl). 1998 Apr;136(3):205-16
pubmed: 9566805
CNS Drugs. 2015 Sep;29(9):801-9
pubmed: 26374743
Eur Arch Psychiatry Clin Neurosci. 1998;248(5):240-4
pubmed: 9840370
J Am Acad Child Adolesc Psychiatry. 2001 Feb;40(2):222-9
pubmed: 11211371
Int Clin Psychopharmacol. 2005 Jul;20(4):223-6
pubmed: 15933483
Eur Neuropsychopharmacol. 2005 Jan;15(1):69-74
pubmed: 15572275
World Psychiatry. 2015 Oct;14(3):304-6
pubmed: 26407782
J Child Fam Stud. 2014 Jul 1;23(5):863-871
pubmed: 24999301
J Clin Psychiatry. 2017 Jul;78(7):e766-e773
pubmed: 28617566
J Clin Psychiatry. 2004 Aug;65(8):1040-8
pubmed: 15323587
PLoS One. 2009;4(3):e4824
pubmed: 19293925
Eur Neuropsychopharmacol. 2000 May;10(3):165-9
pubmed: 10793318
J Clin Psychiatry. 2005 Jun;66(6):736-43
pubmed: 15960567
World J Biol Psychiatry. 2003 Jan;4(1):30-4
pubmed: 12582975
Br J Psychiatry. 1997 Aug;171:135-9
pubmed: 9337948
Br J Psychiatry. 1996 Oct;169(4):468-74
pubmed: 8894198
PLoS One. 2018 Feb 28;13(2):e0193043
pubmed: 29489874
Int Clin Psychopharmacol. 2005 Nov;20(6):299-304
pubmed: 16192837
Am J Psychiatry. 1989 Oct;146(10):1328-30
pubmed: 2675643
Hum Psychopharmacol. 2017 Jul;32(4):
pubmed: 28485008
Prog Neuropsychopharmacol Biol Psychiatry. 1990;14(5):719-27
pubmed: 2293252
Adv Ther. 2017 Feb;34(2):524-541
pubmed: 28044255
Am J Psychiatry. 1996 Sep;153(9):1219-21
pubmed: 8780431
J Clin Psychiatry. 2013 Jun;74(6):e527-32
pubmed: 23842022
CNS Drugs. 2012 Oct 1;26(10):883-92
pubmed: 22873680
Am J Psychiatry. 1988 Dec;145(12):1521-5
pubmed: 3057923
Am J Psychiatry. 1997 Sep;154(9):1261-4
pubmed: 9286186
J Clin Psychopharmacol. 1999 Apr;19(2):172-6
pubmed: 10211919
Eur Psychiatry. 2017 Feb;40:38-44
pubmed: 27837671
BMJ. 2014 May 21;348:g3253
pubmed: 24850821
J Child Adolesc Psychopharmacol. 2003;13 Suppl 1:S19-29
pubmed: 12880497
J Clin Psychiatry. 1994 Oct;55 Suppl:69-76; discussion 77-8
pubmed: 7961535
J Clin Psychopharmacol. 2001 Feb;21(1):46-52
pubmed: 11199947
J Clin Psychopharmacol. 1992 Jun;12(3):156-62
pubmed: 1629380
Arch Gen Psychiatry. 1989 Nov;46(11):1006-11
pubmed: 2684084
J Clin Psychiatry. 2007 Aug;68(8):1213-7
pubmed: 17854245
Psychiatry Res. 2011 Oct 30;189(3):403-6
pubmed: 21329988
J Psychiatr Res. 2004 May-Jun;38(3):323-5
pubmed: 15003438
J Am Acad Child Adolesc Psychiatry. 2002 Dec;41(12):1431-8
pubmed: 12447029
JAMA Psychiatry. 2014 Dec 1;71(12):1409-21
pubmed: 25321611
Curr Neuropharmacol. 2015;13(5):605-15
pubmed: 26467410
Pharmacopsychiatry. 2018 Nov;51(6):263-269
pubmed: 29100251
Prog Neuropsychopharmacol Biol Psychiatry. 2006 May;30(3):413-22
pubmed: 16413647
Acta Psychiatr Scand. 2006 May;113(5):408-19
pubmed: 16603032
J Clin Psychopharmacol. 2011 Apr;31(2):174-9
pubmed: 21346614
Iran J Psychiatry. 2016 Apr;11(2):104-14
pubmed: 27437007
Behav Res Ther. 2013 Dec;51(12):823-9
pubmed: 24184429
J Clin Psychopharmacol. 1991 Jun;11(3):175-84
pubmed: 1820757
Psychopharmacol Bull. 1987;23(1):8-11
pubmed: 3602334
J Clin Psychiatry. 2004 Apr;65(4):565-8
pubmed: 15119922
Am J Psychiatry. 1987 Dec;144(12):1543-8
pubmed: 3120604
Compr Psychiatry. 2017 Feb;73:7-14
pubmed: 27838572
N Engl J Med. 2001 May 24;344(21):1594-602
pubmed: 11372012
J Nerv Ment Dis. 1990 Apr;178(4):268-70
pubmed: 2319236
Curr Med Res Opin. 2007 Apr;23(4):701-11
pubmed: 17407626
J Am Acad Child Adolesc Psychiatry. 1992 Nov;31(6):1062-9
pubmed: 1429406
Arch Gen Psychiatry. 1985 Oct;42(10):977-83
pubmed: 3899048
J Affect Disord. 2017 Aug 15;218:217-226
pubmed: 28477500
JAMA. 2002 Apr 10;287(14):1840-7
pubmed: 11939870
J Clin Psychiatry. 2012 Jun;73(6):856-64
pubmed: 22687813
J Psychiatr Res. 2013 Feb;47(2):175-80
pubmed: 23063327
Psychother Psychosom. 2005;74(5):269-76
pubmed: 16088264
J Psychiatr Res. 2014 Apr;51:21-9
pubmed: 24462042
Arch Gen Psychiatry. 2000 Aug;57(8):794-801
pubmed: 10920469
J Clin Psychiatry. 1990 Jul;51(7):292-7
pubmed: 2195006
Am J Psychiatry. 2005 Jan;162(1):151-61
pubmed: 15625214
Int J Neuropsychopharmacol. 2003 Dec;6(4):397-401
pubmed: 14604454
World Psychiatry. 2017 Jun;16(2):181-192
pubmed: 28498591
Am J Psychiatry. 2002 Jan;159(1):88-95
pubmed: 11772695
Int Clin Psychopharmacol. 1992 Oct;7 Suppl 2:37-41
pubmed: 1484177
J Clin Psychiatry. 2003 Jun;64(6):640-7
pubmed: 12823077
Int Clin Psychopharmacol. 1996 Mar;11(1):21-9
pubmed: 8732310
Biol Psychiatry. 1990 Sep 1;28(5):401-14
pubmed: 2207219
J Clin Psychiatry. 2008 Apr;69(4):681-2; author reply 682
pubmed: 18507494
Psychiatry Clin Neurosci. 2004 Aug;58(4):427-33
pubmed: 15298657
Am J Psychiatry. 1993 May;150(5):819-21
pubmed: 8480832
Neuropsychopharmacology. 2014 May;39(6):1453-9
pubmed: 24356715
Arch Gen Psychiatry. 1994 Apr;51(4):302-8
pubmed: 8161290
J Am Acad Child Adolesc Psychiatry. 2001 Jul;40(7):773-9
pubmed: 11437015
Arch Gen Psychiatry. 1989 Jan;46(1):36-44
pubmed: 2491940
J Clin Psychiatry. 2015 Aug;76(8):1075-84
pubmed: 26214725
BMC Psychiatry. 2005 Jan 24;5:5
pubmed: 15667657
J Am Acad Child Adolesc Psychiatry. 2002 Sep;41(9):1070-7
pubmed: 12218428
Arch Gen Psychiatry. 1991 Aug;48(8):730-8
pubmed: 1883256
J Clin Psychiatry. 2005 Mar;66(3):353-9
pubmed: 15766302
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Nov 13;33(8):1513-6
pubmed: 19737592
Arch Gen Psychiatry. 1995 Apr;52(4):289-95
pubmed: 7702445
JAMA Psychiatry. 2013 Nov;70(11):1190-9
pubmed: 24026523
Psychopharmacology (Berl). 2013 Aug;228(4):633-40
pubmed: 23525525
J Clin Psychopharmacol. 1985 Aug;5(4):207-12
pubmed: 3894437
Am J Psychiatry. 1993 Apr;150(4):647-9
pubmed: 8465885
J Am Acad Child Adolesc Psychiatry. 2004 Nov;43(11):1387-96
pubmed: 15502598
J Clin Psychopharmacol. 2008 Oct;28(5):550-4
pubmed: 18794652
Psychiatry Res. 1987 Jun;21(2):123-36
pubmed: 3615688
JAMA. 2004 Oct 27;292(16):1969-76
pubmed: 15507582
J Clin Psychiatry. 2002 Feb;63(2):138-45
pubmed: 11874215
CNS Spectr. 2010 Nov;15(11):613-7
pubmed: 24726048
J Clin Psychiatry. 2003 Sep;64(9):1113-21
pubmed: 14628989
BMJ. 2006 Feb 18;332(7538):391-7
pubmed: 16452103
J Clin Psychiatry. 2011 May;72(5):716-21
pubmed: 20816027
Arch Gen Psychiatry. 1980 Nov;37(11):1281-5
pubmed: 7436690
J Res Med Sci. 2014 Oct;19(10):976-81
pubmed: 25538783
Am J Psychiatry. 1985 May;142(5):572-6
pubmed: 3885761
Int Clin Psychopharmacol. 2002 May;17(3):115-9
pubmed: 11981352
Am J Psychiatry. 1990 Jul;147(7):923-8
pubmed: 2192564
Arch Gen Psychiatry. 1994 Jul;51(7):559-67
pubmed: 8031229
Arch Gen Psychiatry. 1989 Nov;46(11):1012-6
pubmed: 2510699
Depress Anxiety. 2012 Oct;29(10):850-4
pubmed: 22933237
J Clin Psychopharmacol. 2012 Dec;32(6):797-803
pubmed: 23131885
J Am Acad Child Adolesc Psychiatry. 1991 Jul;30(4):609-16
pubmed: 1890095
J Complement Integr Med. 2011 Oct 11;8:
pubmed: 22718671
Psychiatr Serv. 2015 Aug 1;66(8):817-23
pubmed: 25828873
Nutrition. 2012 Sep;28(9):892-5
pubmed: 22465904
Int J Neuropsychopharmacol. 2012 Aug;15(7):1003-14
pubmed: 22217384
J Clin Psychiatry. 1993 Jul;54(7):272-6
pubmed: 8335655
Complement Ther Med. 2016 Aug;27:25-9
pubmed: 27515872
J Clin Psychopharmacol. 1990 Aug;10(4):261-8
pubmed: 2286699
Neuropsychopharmacology. 2013 Nov;38(12):2475-83
pubmed: 23783065
J Psychopharmacol. 2012 Nov;26(11):1456-62
pubmed: 22351381
Br J Psychiatry. 2014 Jan;204(1):77-8
pubmed: 24262813
Am J Psychiatry. 1990 Sep;147(9):1209-15
pubmed: 2143637
Biol Psychiatry. 2010 Dec 1;68(11):1073-6
pubmed: 20817153
Neuropsychobiology. 2006;53(3):157-68
pubmed: 16707915
Eur Neuropsychopharmacol. 2007 May-Jun;17(6-7):430-9
pubmed: 17240120
Eur Neuropsychopharmacol. 1993 Jun;3(2):143-52
pubmed: 8364350
Eur Neuropsychopharmacol. 2008 Jun;18(6):455-61
pubmed: 18353618