Effects of trauma, economic hardship, and stress on neurocognition and everyday function in HIV.
Journal
Health psychology : official journal of the Division of Health Psychology, American Psychological Association
ISSN: 1930-7810
Titre abrégé: Health Psychol
Pays: United States
ID NLM: 8211523
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
pubmed:
30
10
2018
medline:
19
1
2019
entrez:
30
10
2018
Statut:
ppublish
Résumé
The causes of neurocognitive and everyday functioning impairment among aging people living with HIV (PLWH) are multifactorial. Exposure to stress and trauma can result in neurocognitive deficits via activation of neurological and other biological mechanisms. PLWH (n = 122) and persons without HIV (n = 95), 35-65 years of age, completed four questionnaires that were used to generate a trauma, economic hardship (food insecurity and low socioeconomic status), and stress composite variable (TES). Participants also completed a comprehensive neuropsychological battery and standardized self-reports of activities of daily living (ADLs). We examined the independent and interactive effects of TES and HIV status on neurocognitive performance and ADL declines. PLWH had more traumatic events, more food insecurity, lower socioeconomic status, and higher perceived stress compared with HIV- individuals (all ps < .0001). Among PLWH, a higher composite TES score was associated with worse executive functioning (p = .02), worse learning (p = .02), worse working memory (p = .02), and more ADL declines (p < .0001), even after controlling for relevant demographic, psychiatric, substance use, and HIV disease covariates. On their own, individual TES components did not predict these outcomes. Conversely, no significant relationships were observed between TES and cognitive domains nor ADL declines among HIV- individuals. A composite score of trauma, economic hardship, and stress was significantly associated with worse neurocognitive performance and functional declines among PLWH. These adverse experiences may contribute to neurocognitive and daily functioning difficulties commonly observed among PLWH. Longitudinal studies are needed to elucidate the relationships between economic/psychosocial adversities and cognitive/functional outcomes over time, and examine potential mediators, such as inflammatory biomarkers. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
Identifiants
pubmed: 30372103
pii: 2018-53586-001
doi: 10.1037/hea0000688
pmc: PMC6309226
mid: NIHMS993911
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
33-42Subventions
Organisme : NIMH NIH HHS
ID : R25 MH081482
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA031098
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH107260
Pays : United States
Organisme : NIMH NIH HHS
ID : P30 MH062512
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH099987
Pays : United States
Organisme : UC San Diego's Sam and Rose Stein Institute for Research on Aging
Références
J Neuropsychiatry Clin Neurosci. 2003 Fall;15(4):436-41
pubmed: 14627770
J Clin Exp Neuropsychol. 2011 Aug;33(7):793-804
pubmed: 21547817
Neuron. 2009 Oct 15;64(1):33-9
pubmed: 19840546
Neurobiol Dis. 2016 Aug;92(Pt B):166-74
pubmed: 26408051
Top HIV Med. 2010 Apr-May;18(2):45-55
pubmed: 20516524
Brain Imaging Behav. 2018 Feb;12(1):96-108
pubmed: 28130744
Dev Cogn Neurosci. 2017 Feb;23:39-44
pubmed: 28011437
AIDS Behav. 2011 Aug;15(6):1098-110
pubmed: 20963630
Int J Geriatr Psychiatry. 2014 Jun;29(6):645-52
pubmed: 24302253
AIDS Behav. 2012 Nov;16(8):2319-29
pubmed: 22673969
Am J Public Health. 2006 Jun;96(6):1028-30
pubmed: 16670226
Neurosci Biobehav Rev. 2015 Nov;58:79-91
pubmed: 26116544
J Neurovirol. 2011 Feb;17(1):3-16
pubmed: 21174240
Br J Psychiatry. 1991 Nov;159:645-53, 658
pubmed: 1756340
Am J Public Health. 2013 May;103(5):813-21
pubmed: 23488505
J Int Neuropsychol Soc. 2004 May;10(3):317-31
pubmed: 15147590
Neurology. 2010 Sep 28;75(13):1150-8
pubmed: 20739646
J Clin Exp Neuropsychol. 2013;35(1):49-58
pubmed: 23237014
J Neurovirol. 2016 Dec;22(6):840-851
pubmed: 27094924
Gerontologist. 1969 Autumn;9(3):179-86
pubmed: 5349366
Neurology. 2009 May 12;72(19):1661-8
pubmed: 19433739
BMJ Open. 2016 Jul 13;6(7):e011453
pubmed: 27412106
Clin Neuropsychol. 2012;26(6):894-908
pubmed: 22708483
J Health Soc Behav. 1983 Dec;24(4):385-96
pubmed: 6668417
J Int Neuropsychol Soc. 2012 Jul;18(4):657-68
pubmed: 22621973
Arch Clin Neuropsychol. 2012 May;27(3):293-303
pubmed: 22337933
J Trauma Stress. 2015 Dec;28(6):489-98
pubmed: 26606250
PLoS One. 2013 Dec 18;8(12):e81355
pubmed: 24367482
AIDS Care. 2009 Jun;21(6):742-53
pubmed: 19806490
Open Forum Infect Dis. 2017 Apr 06;4(2):ofx070
pubmed: 28584853
Nat Rev Neurosci. 2009 Jun;10(6):434-45
pubmed: 19401723
South Med J. 2007 Nov;100(11):1114-22
pubmed: 17984744
AIDS Behav. 2012 Nov;16(8):2091-100
pubmed: 22249954
AIDS Read. 2008 Mar;18(3):144-6, 152-8, C3
pubmed: 18398985
Neurology. 2010 Dec 7;75(23):2087-96
pubmed: 21135382
J Health Psychol. 2010 Jan;15(1):107-14
pubmed: 20064889
J Clin Exp Neuropsychol. 2011 Jun;33(5):505-22
pubmed: 21391011
Neurobiol Stress. 2016 Feb 11;4:44-54
pubmed: 27981189
J Low Genit Tract Dis. 2011 Jan;15(1):42-7
pubmed: 21192176
Health Psychol. 2017 Feb;36(2):133-142
pubmed: 27929330
Health Psychol. 2009 Mar;28(2):137-46
pubmed: 19290705
AIDS Behav. 2017 Mar;21(3):783-791
pubmed: 27492024
Br J Psychiatry. 2012 Jun;200(6):469-75
pubmed: 22661679
J Neurovirol. 2016 Apr;22(2):149-58
pubmed: 26424107
Clin Neuropsychol. 2015;29(2):232-54
pubmed: 25871409
Syst Rev. 2012 Jun 28;1:30
pubmed: 22742536
J Neurovirol. 2015 Aug;21(4):422-32
pubmed: 25791344
Memory. 2007 Jan;15(1):57-62
pubmed: 17479924