Torque Teno Virus Is Associated With the State of Immune Suppression Early After Liver Transplantation.
Adult
Aged
Allografts
/ immunology
Biomarkers
/ blood
Biopsy
Cytomegalovirus
/ isolation & purification
Cytomegalovirus Infections
/ blood
DNA, Viral
/ isolation & purification
Female
Follow-Up Studies
Graft Rejection
/ diagnosis
Host Microbial Interactions
/ immunology
Humans
Immune Tolerance
Immunosuppression Therapy
/ adverse effects
Liver
/ immunology
Liver Transplantation
/ adverse effects
Male
Middle Aged
Opportunistic Infections
/ blood
Postoperative Period
Prospective Studies
Real-Time Polymerase Chain Reaction
Retrospective Studies
Torque teno virus
/ genetics
Viral Load
Viremia
/ immunology
Journal
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
ISSN: 1527-6473
Titre abrégé: Liver Transpl
Pays: United States
ID NLM: 100909185
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
27
07
2018
accepted:
20
10
2018
pubmed:
31
10
2018
medline:
15
2
2020
entrez:
31
10
2018
Statut:
ppublish
Résumé
The development of noninvasive biomarkers that reflect the state of immunosuppression (IS) remains an unmet need in liver transplantation (LT). Torque Teno virus (TTV) is a highly prevalent, nonpathogenic DNA virus whose plasma levels may be associated with the immune status of the host. The aim of this study was to assess the role of TTV as a biomarker of IS in LT recipients. TTV DNA in plasma was quantified by real-time polymerase chain reaction at different time points during the first year after transplant in a prospectively followed cohort of 63 de novo LT recipients, and any correlation between TTV DNA and biopsy-proven acute cellular rejection (ACR) and opportunistic infections was then evaluated. In addition, TTV DNA was studied in 10 longterm LT recipients in monotherapy with tacrolimus, 10 tolerant recipients, and 10 healthy controls. TTV was detected in the plasma of all patients. Among the 63 LT recipients, 20 episodes of ACR were diagnosed, and there were 28 opportunistic infections, 26 of them being cytomegalovirus (CMV) infections. TTV viremia was significantly lower during ACR (4.41 versus 5.95 log
Substances chimiques
Biomarkers
0
DNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
302-310Informations de copyright
Copyright © 2018 by the American Association for the Study of Liver Diseases.