Effects of BDNF Val
Adult
Brain-Derived Neurotrophic Factor
/ genetics
Connectome
Executive Function
/ physiology
Female
Genetic Predisposition to Disease
Gyrus Cinguli
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Net
/ physiopathology
Neuronal Plasticity
/ genetics
Polymorphism, Single Nucleotide
Prefrontal Cortex
/ diagnostic imaging
Schizophrenia
/ genetics
Young Adult
Journal
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
ISSN: 1740-634X
Titre abrégé: Neuropsychopharmacology
Pays: England
ID NLM: 8904907
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
01
06
2018
accepted:
16
10
2018
revised:
25
09
2018
pubmed:
31
10
2018
medline:
19
12
2019
entrez:
31
10
2018
Statut:
ppublish
Résumé
Cognitive control represents an essential neuropsychological characteristic that allows for the rapid adaption of a changing environment by constant re-allocation of cognitive resources. This finely tuned mechanism is impaired in psychiatric disorders such as schizophrenia and contributes to cognitive deficits. Neuroimaging has highlighted the contribution of the anterior cingulate cortex (ACC) and prefrontal regions (PFC) on cognitive control and demonstrated the impact of genetic variation, as well as genetic liability for schizophrenia. In this study, we aimed to examine the influence of the functional single-nucleotide polymorphism (SNP) rs6265 of a plasticity-related neurotrophic factor gene, BDNF (Val
Identifiants
pubmed: 30375508
doi: 10.1038/s41386-018-0248-9
pii: 10.1038/s41386-018-0248-9
pmc: PMC6333795
doi:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
BDNF protein, human
7171WSG8A2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
590-597Références
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