Peripheral CD19
CD19+ B-cell counts
Monoclonal anti-CD20 antibody
Multiple sclerosis
Neuromyelitis optica
Neuromyelitis optica spectrum disorders
Journal
Journal of neurology
ISSN: 1432-1459
Titre abrégé: J Neurol
Pays: Germany
ID NLM: 0423161
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
10
06
2018
accepted:
10
10
2018
revised:
25
09
2018
pubmed:
1
11
2018
medline:
8
5
2019
entrez:
1
11
2018
Statut:
ppublish
Résumé
With ocrelizumab another drug is available for the treatment of multiple sclerosis (MS). Little is known on the long-term use of ocrelizumab on immune cell subsets, and no surrogate markers are available. Rituximab (RTX) has been in off-label use for the treatment of MS, neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorder (NMOSD) for > 10 years. We evaluated the long-term depletion and repopulation rate of peripheral CD19 We evaluated the CD19 CD19 Our data suggest that CD19
Sections du résumé
BACKGROUND
BACKGROUND
With ocrelizumab another drug is available for the treatment of multiple sclerosis (MS). Little is known on the long-term use of ocrelizumab on immune cell subsets, and no surrogate markers are available. Rituximab (RTX) has been in off-label use for the treatment of MS, neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorder (NMOSD) for > 10 years.
OBJECTIVE
OBJECTIVE
We evaluated the long-term depletion and repopulation rate of peripheral CD19
METHODS
METHODS
We evaluated the CD19
RESULTS
RESULTS
CD19
CONCLUSION
CONCLUSIONS
Our data suggest that CD19
Identifiants
pubmed: 30377816
doi: 10.1007/s00415-018-9092-4
pii: 10.1007/s00415-018-9092-4
pmc: PMC6342886
doi:
Substances chimiques
Antigens, CD19
0
CD19 molecule, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
57-67Références
Ann Neurol. 2010 Apr;67(4):452-61
pubmed: 20437580
Ann Neurol. 2005 Dec;58(6):840-6
pubmed: 16283615
Neurol Neuroimmunol Neuroinflamm. 2017 Jun 05;4(4):e360
pubmed: 28626781
N Engl J Med. 2008 Feb 14;358(7):676-88
pubmed: 18272891
Lancet Neurol. 2017 Feb;16(2):104-106
pubmed: 28102146
Mult Scler. 2018 Jul;24(8):1087-1095
pubmed: 28649912
Autoimmunity. 2017 Feb;50(1):57-60
pubmed: 28166681
N Engl J Med. 2017 Jan 19;376(3):221-234
pubmed: 28002679
Hum Vaccin Immunother. 2018;14(12):2820-2841
pubmed: 30096012
Trends Mol Med. 2013 May;19(5):309-19
pubmed: 23582699
Ann Neurol. 2008 Mar;63(3):395-400
pubmed: 18383069
Blood. 1994 Jan 15;83(2):435-45
pubmed: 7506951
J Immunol. 2014 Jul 15;193(2):580-586
pubmed: 24928997
Cell. 2018 Sep 20;175(1):85-100.e23
pubmed: 30173916
N Engl J Med. 2017 Apr 27;376(17):1694
pubmed: 28445663
J Neurol. 2017 Sep;264(9):2003-2009
pubmed: 28831548
Neurology. 2006 May 23;66(10):1485-9
pubmed: 16717206
Neurology. 2016 Nov 15;87(20):2074-2081
pubmed: 27760868
Ann Neurol. 2009 Oct;66(4):460-71
pubmed: 19847908