α-Smooth muscle actin expression predicts the outcome of Kasai portoenterostomy in biliary atresia.
Actins
/ metabolism
Biliary Atresia
/ metabolism
Female
Fibrosis
/ classification
Giant Cells
/ pathology
Hematopoiesis, Extramedullary
/ physiology
Humans
Infant
Jaundice
/ epidemiology
Liver
/ pathology
Male
Muscle, Smooth
/ metabolism
Portoenterostomy, Hepatic
/ methods
Predictive Value of Tests
Prospective Studies
Treatment Outcome
Biliary atresia
Kasai portoenterostomy
α-smooth muscle actin
Journal
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
ISSN: 1998-4049
Titre abrégé: Saudi J Gastroenterol
Pays: India
ID NLM: 9516979
Informations de publication
Date de publication:
Historique:
pubmed:
2
11
2018
medline:
23
4
2019
entrez:
2
11
2018
Statut:
ppublish
Résumé
Biliary atresia (BA) is a cholangio-destructive disease of the infant liver presenting with features of obstructive cholangiopathy. The Kasai portoenterostomy (KPE) is the first line of management. The aim of our study was to identify the characteristic features of liver histology in BA that impact the outcome of KPE. Data from 30 consecutive children was retrieved from our prospectively maintained database of children undergoing KPE. This included basic demographics, laboratory values and histopathological data from liver biopsy. The stages of fibrosis, presence of ductal plate malformation (DPM), giant cell transformation, extramedullary hematopoiesis and area percentage of α-SMA (α-smooth muscle actin) expression was correlated with jaundice clearance after KPE using standard statistical tests. Native liver survival was computed. Overall, 13 (43%) children cleared jaundice in this series and 10 (33%) are alive with native liver. Lower area percent expression of α-SMA correlated with increased probability of jaundice clearance after KPE (P < 0.001). There was no correlation between stage of fibrosis and jaundice clearance (P = 0.52). DPM, giant cell transformation and extramedullary hematopoiesis did not correlate with outcome. All children who are alive with native liver had lower expression of α-SMA. α-SMA expression may be a potential predictor of jaundice clearance and native liver survival after KPE.
Sections du résumé
BACKGROUND/AIMS
OBJECTIVE
Biliary atresia (BA) is a cholangio-destructive disease of the infant liver presenting with features of obstructive cholangiopathy. The Kasai portoenterostomy (KPE) is the first line of management. The aim of our study was to identify the characteristic features of liver histology in BA that impact the outcome of KPE.
PATIENTS AND METHODS
METHODS
Data from 30 consecutive children was retrieved from our prospectively maintained database of children undergoing KPE. This included basic demographics, laboratory values and histopathological data from liver biopsy. The stages of fibrosis, presence of ductal plate malformation (DPM), giant cell transformation, extramedullary hematopoiesis and area percentage of α-SMA (α-smooth muscle actin) expression was correlated with jaundice clearance after KPE using standard statistical tests. Native liver survival was computed.
RESULTS
RESULTS
Overall, 13 (43%) children cleared jaundice in this series and 10 (33%) are alive with native liver. Lower area percent expression of α-SMA correlated with increased probability of jaundice clearance after KPE (P < 0.001). There was no correlation between stage of fibrosis and jaundice clearance (P = 0.52). DPM, giant cell transformation and extramedullary hematopoiesis did not correlate with outcome. All children who are alive with native liver had lower expression of α-SMA.
CONCLUSION
CONCLUSIONS
α-SMA expression may be a potential predictor of jaundice clearance and native liver survival after KPE.
Identifiants
pubmed: 30381493
pii: 244710
doi: 10.4103/sjg.SJG_242_18
pmc: PMC6457180
doi:
Substances chimiques
ACTA2 protein, human
0
Actins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101-105Déclaration de conflit d'intérêts
None
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