Induced CD20 Expression on B-Cell Malignant Cells Heightened the Cytotoxic Activity of Chimeric Antigen Receptor Engineered T Cells.

Animals Antigens, CD20 / genetics Antineoplastic Agents / pharmacology B-Lymphocytes / immunology Biomarkers Cell Line, Tumor Combined Modality Therapy Cytotoxicity, Immunologic / drug effects Disease Models, Animal Female Gene Expression Genes, Reporter Histone Deacetylase Inhibitors / pharmacology Humans Immunophenotyping Immunotherapy, Adoptive / methods Lymphoma, B-Cell / genetics Mice Receptors, Chimeric Antigen / metabolism T-Cell Antigen Receptor Specificity / genetics T-Lymphocytes / immunology Xenograft Model Antitumor Assays
B-cell malignancies CD20 HDAC inhibitor Immunotherapy chimeric antigen receptor

Journal

Human gene therapy
ISSN: 1557-7422
Titre abrégé: Hum Gene Ther
Pays: United States
ID NLM: 9008950

Informations de publication

Date de publication:
04 2019
Historique:
pubmed: 2 11 2018
medline: 12 3 2020
entrez: 2 11 2018
Statut: ppublish

Résumé

CD20 is an effective immunotherapy target for CD20

Identifiants

DOI: 10.1089/hum.2018.119 PMID: 30381966
pubmed: 30381966
doi: 10.1089/hum.2018.119
doi:

Substances chimiques

Antigens, CD20 0
Antineoplastic Agents 0
Biomarkers 0
Histone Deacetylase Inhibitors 0
Receptors, Chimeric Antigen 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

497-510

Commentaires et corrections

Type : ErratumIn

Auteurs

Yingxi Xu (Y)

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.

Saisai Li (S)

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.

Ying Wang (Y)

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.

Jia Liu (J)

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.

Xinhe Mao (X)

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.

Haiyan Xing (H)

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.

Zheng Tian (Z)

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.

Kejing Tang (K)

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.

Xiaolong Liao (X)

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.

Qing Rao (Q)

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.

Dongsheng Xiong (D)

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.

Min Wang (M)

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.

Jianxiang Wang (J)

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Induced CD20 Expression on B-Cell Malignant...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes B › Antigènes CD20 › Induced CD20 Expression on B-Cell Malignant...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Induced CD20 Expression on B-Cell Malignant...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Induced CD20 Expression on B-Cell Malignant...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Induced CD20 Expression on B-Cell Malignant...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Induced CD20 Expression on B-Cell Malignant...
questionsmedicales.fr › Thérapeutique › Association thérapeutique › Induced CD20 Expression on B-Cell Malignant...
questionsmedicales.fr › Phénomènes du système immunitaire › Cytotoxicité immunologique › Induced CD20 Expression on B-Cell Malignant...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Induced CD20 Expression on B-Cell Malignant...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Induced CD20 Expression on B-Cell Malignant...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes rapporteurs › Induced CD20 Expression on B-Cell Malignant...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de désacétylase d'histone › Induced CD20 Expression on B-Cell Malignant...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Induced CD20 Expression on B-Cell Malignant...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Immunophénotypage › Induced CD20 Expression on B-Cell Malignant...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunisation passive › Transfert adoptif › Immunothérapie adoptive › Induced CD20 Expression on B-Cell Malignant...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Lymphomes › Lymphome malin non hodgkinien › Lymphome B › Induced CD20 Expression on B-Cell Malignant...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Induced CD20 Expression on B-Cell Malignant...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs chimériques pour l'antigène › Induced CD20 Expression on B-Cell Malignant...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Spécificité antigénique des récepteurs des lymphocytes T › Induced CD20 Expression on B-Cell Malignant...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Induced CD20 Expression on B-Cell Malignant...
questionsmedicales.fr › Techniques d'investigation › Transplantation tumorale › Tests d'activité antitumorale sur modèle de xénogreffe › Induced CD20 Expression on B-Cell Malignant...