Molecular characterization of hepatitis B virus in blood donors in Botswana.
Adolescent
Adult
Aged
Amino Acid Sequence
Blood Donors
Botswana
/ epidemiology
Cross-Sectional Studies
DNA, Viral
/ genetics
Female
Genotype
Hepatitis B
/ epidemiology
Hepatitis B virus
/ genetics
Humans
Male
Middle Aged
Mutation
Phylogeny
Polymerase Chain Reaction
Population Surveillance
Prevalence
Serogroup
Young Adult
Blood donors
Botswana
HBV
Mutations
Sub-genotypes
Journal
Virus genes
ISSN: 1572-994X
Titre abrégé: Virus Genes
Pays: United States
ID NLM: 8803967
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
13
06
2018
accepted:
25
10
2018
pubmed:
2
11
2018
medline:
23
2
2019
entrez:
2
11
2018
Statut:
ppublish
Résumé
Hepatitis B virus (HBV) poses a significant threat to blood transfusion safety in sub-Saharan Africa (SSA) where allogeneic blood donations are screened serologically, and more sensitive nucleic acid tests (NATs) are utilized infrequently. HBV strains circulating among blood donors in Botswana are not yet characterized. We designed a cross-sectional study to determine the HBV sub-genotypes and prevalence of hepatitis B surface antigen (HBsAg) among blood donors between November 2014 and October 2015. A total of 12,575 blood donations were screened for HBsAg and 50 consecutive plasma samples were selected for genotyping from confirmed HBsAg
Identifiants
pubmed: 30382563
doi: 10.1007/s11262-018-1610-z
pii: 10.1007/s11262-018-1610-z
pmc: PMC6563613
mid: NIHMS1020151
doi:
Substances chimiques
DNA, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
33-42Subventions
Organisme : SANTHE
ID : DEL-15-006
Organisme : Wellcome Trust
ID : 107752/Z/15/Z
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : P30 DK078392
Pays : United States
Organisme : FIC NIH HHS
ID : D43 TW009610
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
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