Reduced brain amyloid burden in elderly patients with narcolepsy type 1.
Journal
Annals of neurology
ISSN: 1531-8249
Titre abrégé: Ann Neurol
Pays: United States
ID NLM: 7707449
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
22
12
2017
revised:
26
10
2018
accepted:
26
10
2018
pubmed:
6
11
2018
medline:
26
11
2019
entrez:
3
11
2018
Statut:
ppublish
Résumé
To determine whether brain amyloid burden in elderly patients with narcolepsy type 1 (NT1) is lower than in controls, and to assess in patients with NT1 the relationships between amyloid burden, cerebral spinal fluid (CSF) markers of Alzheimer disease (AD), CSF orexin-A, and cognitive profile. Cognitive and Lower cortical amyloid burden was observed in the NT1 than in the ADNI and MAPT-AV45 groups (mean cortical/cerebellum SUV ratios = 0.95 ± 0.15, 1.11 ± 0.18 [p < 0.0001], and 1.14 ± 0.17 [p = 0.0005], respectively). Similar results were obtained with all subcortical reference regions and for all cortical regions of interest, except cingulum. Only 1 patient with NT1 (4.4%) had positive PET amyloid compared with 27.5% in the ADNI and 30.4% in the MAPT-AV45 group. In the NT1 group, cortical or regional amyloid load was not associated with CSF orexin-A, CSF AD biomarkers, or neuropsychological profile. Lower brain amyloid burden, assessed by
Substances chimiques
Amyloid beta-Peptides
0
Banques de données
ClinicalTrials.gov
['NCT03378453']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
74-83Subventions
Organisme : Montpellier University Hospital Center
ID : NCT03378453
Pays : International
Organisme : Gérontopôle of Toulouse
Pays : International
Organisme : French Ministry of Health
ID : PHRC 2008, 2009
Pays : International
Organisme : Pierre Fabre Research Institute
Pays : International
Organisme : ExonHit Therapeutics
Pays : International
Organisme : Avid Radiopharmaceuticals
Pays : International
Organisme : University Hospital Center of Toulouse
Pays : International
Organisme : Monaco Association for Research on Alzheimer's Disease
Pays : International
Organisme : National Institute of Health and Medical Research
Pays : International
Organisme : University of Toulouse III
Pays : International
Investigateurs
Bruno Vellas
(B)
Sophie Guyonnet
(S)
Isabelle Carrié
(I)
Lauréane Brigitte
(L)
Catherine Faisant
(C)
Françoise Lala
(F)
Julien Delrieu
(J)
Hélène Villars
(H)
Emeline Combrouze
(E)
Carole Badufle
(C)
Audrey Zueras
(A)
Sandrine Andrieu
(S)
Christelle Cantet
(C)
Christophe Morin
(C)
Gabor Abellan Van Kan
(GA)
Charlotte Dupuy
(C)
Yves Rolland
(Y)
Céline Caillaud
(C)
Pierre-Jean Ousset
(PJ)
Françoise Lala
(F)
Bertrand Fougère
(B)
Sherry Willis
(S)
Sylvie Belleville
(S)
Brigitte Gilbert
(B)
Francine Fontaine
(F)
Jean-François Dartigues
(JF)
Isabelle Marcet
(I)
Fleur Delva
(F)
Alexandra Foubert
(A)
Sandrine Cerda
(S)
Corinne Costes
(C)
Olivier Rouaud
(O)
Patrick Manckoundia
(P)
Valérie Quipourt
(V)
Sophie Marilier
(S)
Evelyne Franon
(E)
Lawrence Bories
(L)
Marie-Laure Pader
(ML)
Marie-France Basset
(MF)
Bruno Lapoujade
(B)
Valérie Faure
(V)
Michael Li Yung Tong
(MLY)
Christine Malick-Loiseau
(C)
Evelyne Cazaban-Campistron
(E)
Françoise Desclaux
(F)
Colette Blatge
(C)
Thierry Dantoine
(T)
Cécile Laubarie-Mouret
(C)
Isabelle Saulnier
(I)
Jean-Pierre Clément
(JP)
Marie-Agnès Picat
(MA)
Laurence Bernard-Bourzeix
(L)
Stéphanie Willebois
(S)
Iléana Désormais
(I)
Noëlle Cardinaud
(N)
Marc Bonnefoy
(M)
Pierre Livet
(P)
Pascale Rebaudet
(P)
Claire Gédéon
(C)
Catherine Burdet
(C)
Flavien Terracol
(F)
Alain Pesce
(A)
Stéphanie Roth
(S)
Sylvie Chaillou
(S)
Sandrine Louchart
(S)
Kristelle Sudres
(K)
Nicolas Lebrun
(N)
Nadège Barro-Belaygues
(N)
Jacques Touchon
(J)
Karim Bennys
(K)
Audrey Gabelle
(A)
Aurélia Romano
(A)
Lynda Touati
(L)
Cécilia Marelli
(C)
Cécile Pays
(C)
Patrice Douillet
(P)
Philippe Robert
(P)
Franck Le Duff
(F)
Claire Gervais
(C)
Sébastien Gonfrier
(S)
Yves Gasnier
(Y)
Serge Bordes
(S)
Danièle Begorre
(D)
Christian Carpuat
(C)
Khaled Khales
(K)
Jean-François Lefebvre
(JF)
Samira Misbah El Idrissi
(SM)
Pierre Skolil
(P)
Jean-Pierre Salles
(JP)
Carole Dufouil
(C)
Stéphane Lehéricy
(S)
Marie Chupin
(M)
Jean-François Mangin
(JF)
Ali Bouhayia
(A)
Michèle Allard
(M)
Frédéric Ricolfi
(F)
Dominique Dubois
(D)
Marie Paule Bonceour Martel
(MPB)
François Cotton
(F)
Alain Bonafé
(A)
Stéphane Chanalet
(S)
Françoise Hugon
(F)
Fabrice Bonneville
(F)
Christophe Cognard
(C)
François Chollet
(F)
Pierre Payoux
(P)
Thierry Voisin
(T)
Julien Delrieu
(J)
Sophie Peiffer
(S)
Anne Hitzel
(A)
Michèle Allard
(M)
Michel Zanca
(M)
Jacques Monteil
(J)
Jacques Darcourt
(J)
Laurent Molinier
(L)
Hélène Derumeaux
(H)
Nadège Costa
(N)
Christian Vincent
(C)
Bertrand Perret
(B)
Claire Vinel
(C)
Pascale Olivier-Abbal
(P)
Sandrine Andrieu
(S)
Stéphanie Savy
(S)
Christelle Cantet
(C)
Nicola Coley
(N)
Informations de copyright
© 2018 American Neurological Association.