Recent advances in the synthesis of phthalazin-1(2H)-one core as a relevant pharmacophore in medicinal chemistry.
Biological versatility
Cyclocondensations
Multicomponent reactions
Phthalazinone derivatives
Synthesis
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
01 Jan 2019
01 Jan 2019
Historique:
received:
17
07
2018
revised:
18
10
2018
accepted:
19
10
2018
pubmed:
6
11
2018
medline:
19
12
2018
entrez:
3
11
2018
Statut:
ppublish
Résumé
Phthalazin-1(2H)-one is a diazaheterobicycle found in a wide variety of synthetic molecules relevant to several branches of chemistry, including medicinal chemistry. The versatility of phthalazinone core in drug discovery has promoted the search for new synthetic methods to get access to differently substituted and functionalized derivatives. This review highlights the latest advances in synthesis of phthalazinone derivatives that have relevance to drug discovery processes, analyzing modifications of classical methodologies based on [4 + 2] two-component cyclocondensations as well as novel multicomponent approaches, mostly based on a [3 + 2+1] three-component strategy and very attractive not only because of its synthetic efficiency but also in the matter of environmental compatibility.
Identifiants
pubmed: 30388463
pii: S0223-5234(18)30916-4
doi: 10.1016/j.ejmech.2018.10.047
pii:
doi:
Substances chimiques
Phthalazines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
468-478Informations de copyright
Copyright © 2018 Elsevier Masson SAS. All rights reserved.