Androgen treatment effects on hippocampus structure in boys with Klinefelter syndrome.
Adolescent
Androgens
/ pharmacology
Brain
/ drug effects
Child
Child Development
/ drug effects
Double-Blind Method
Hippocampus
/ diagnostic imaging
Humans
Intelligence
/ drug effects
Klinefelter Syndrome
/ diagnosis
Magnetic Resonance Imaging
Male
Oxandrolone
/ pharmacology
Verbal Behavior
/ drug effects
Androgens
Cognition
Genetics
Magnetic resonance imaging
Structural magnetic resonance imaging
Journal
Psychoneuroendocrinology
ISSN: 1873-3360
Titre abrégé: Psychoneuroendocrinology
Pays: England
ID NLM: 7612148
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
30
03
2018
revised:
27
09
2018
accepted:
28
09
2018
pubmed:
6
11
2018
medline:
25
3
2020
entrez:
3
11
2018
Statut:
ppublish
Résumé
Klinefelter syndrome (KS, 47,XXY) is the most common sex chromosome aneuploidy in males. A variety of complex clinical needs is associated with KS, including physical, cognitive and psychosocial impairments. Standard treatment for KS consists of androgen replacement therapy in adolescence to offset testosterone deficiency. Such treatment has a beneficial effect on the physical and behavioral manifestations of this syndrome. Whether androgen supplementation has a significant influence on the brain, however, is unknown. In the current study, we examined regional gray matter volume in boys with KS to assess whether treatment with oxandrolone, a synthetic hormone analog of testosterone, was associated with structural changes in the brain. Specifically, we focused our investigation on the hippocampus, given (1) its involvement in KS, and (2) the high concentration of androgen receptors found in this region. Structural magnetic resonance imaging data was acquired from a subsample of boys who completed a 2-year double-blind clinical trial in which patients were randomized to treatment with oxandrolone or to placebo, as well as from a sample of typically developing (TD) boys. Group differences in hippocampal volume were examined. A significant main effect of group was observed. Pairwise comparisons indicated smaller hippocampal volume in the placebo group relative to the oxandrolone group, as well as smaller volume in the placebo group relative to the TD control group. No difference in volume was observed between the treatment and TD groups. Moreover, across KS subgroups, a significant positive association was observed between hippocampus volume and performance on a spatial memory task, indicating treatment-based changes in brain structure may underlie cognitive change. These findings confirm prior reports implicating a role of the hippocampus in KS and are important in extending previous research by demonstrating a significant effect of androgens on brain structure.
Identifiants
pubmed: 30388596
pii: S0306-4530(18)30296-8
doi: 10.1016/j.psyneuen.2018.09.039
pmc: PMC6644684
mid: NIHMS1510895
pii:
doi:
Substances chimiques
Androgens
0
Oxandrolone
7H6TM3CT4L
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
223-228Subventions
Organisme : NINDS NIH HHS
ID : R01 NS050597
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.
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