The kinetochore module Okp1
Amino Acid Sequence
Amino Acid Substitution
Cell Cycle Proteins
/ genetics
Centromere
/ metabolism
Centromere Protein A
/ chemistry
Chromosomal Proteins, Non-Histone
/ chemistry
DNA-Binding Proteins
/ chemistry
Kinetochores
/ metabolism
Microtubule-Associated Proteins
/ genetics
Mutation, Missense
Organisms, Genetically Modified
Protein Domains
Protein Processing, Post-Translational
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
/ chemistry
Ame1
Gcn5
Okp1
centromere
posttranslational modification
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
03 01 2019
03 01 2019
Historique:
received:
09
01
2018
revised:
01
10
2018
accepted:
05
10
2018
pubmed:
6
11
2018
medline:
1
1
2020
entrez:
4
11
2018
Statut:
ppublish
Résumé
Kinetochores are supramolecular assemblies that link centromeres to microtubules for sister chromatid segregation in mitosis. For this, the inner kinetochore CCAN/Ctf19 complex binds to centromeric chromatin containing the histone variant CENP-A, but whether the interaction of kinetochore components to centromeric nucleosomes is regulated by posttranslational modifications is unknown. Here, we investigated how methylation of arginine 37 (R37Me) and acetylation of lysine 49 (K49Ac) on the CENP-A homolog Cse4 from
Identifiants
pubmed: 30389668
pii: embj.201898991
doi: 10.15252/embj.201898991
pmc: PMC6315295
pii:
doi:
Substances chimiques
Ame1 protein, S cerevisiae
0
CSE4 protein, S cerevisiae
0
Cell Cycle Proteins
0
Centromere Protein A
0
Chromosomal Proteins, Non-Histone
0
DNA-Binding Proteins
0
Microtubule-Associated Proteins
0
Okp1 protein, S cerevisiae
0
Saccharomyces cerevisiae Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 103139
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 103139/Z/13/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203149
Pays : United Kingdom
Informations de copyright
© 2018 The Authors.
Références
Genes Dev. 2007 Dec 15;21(24):3319-30
pubmed: 18079178
Genes Dev. 2003 Dec 1;17(23):2902-21
pubmed: 14633972
Methods Enzymol. 1991;194:3-21
pubmed: 2005794
Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):E5583-9
pubmed: 26430240
Protein Expr Purif. 2005 Apr;40(2):385-95
pubmed: 15766881
Genes Dev. 2003 Nov 1;17(21):2648-63
pubmed: 14563679
Elife. 2014 Jul 15;3:e02137
pubmed: 25027692
Nat Cell Biol. 2006 May;8(5):458-69
pubmed: 16622419
Dev Cell. 2003 Dec;5(6):853-64
pubmed: 14667408
Nat Struct Mol Biol. 2016 Mar;23(3):204-208
pubmed: 26878239
Genes Dev. 1994 May 1;8(9):1087-105
pubmed: 7926789
Mol Cell Biol. 1991 Nov;11(11):5648-59
pubmed: 1922068
Cell. 1990 May 4;61(3):437-46
pubmed: 2185892
Genes Cells. 2006 Jun;11(6):673-84
pubmed: 16716197
Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11827-32
pubmed: 23818633
Mutat Res. 2007 May 1;618(1-2):135-48
pubmed: 17337012
Curr Biol. 2009 Apr 28;19(8):694-9
pubmed: 19345105
Mol Cell. 1999 Jul;4(1):123-8
pubmed: 10445034
Cell. 2012 Jul 20;150(2):304-16
pubmed: 22817893
Trends Cell Biol. 2013 Jun;23(6):260-9
pubmed: 23481674
Genes Dev. 1999 May 1;13(9):1140-55
pubmed: 10323865
Genes Dev. 2017 Oct 1;31(19):1958-1972
pubmed: 29074736
Biology (Basel). 2017 Jan 24;6(1):
pubmed: 28125021
Cell. 1996 Mar 22;84(6):843-51
pubmed: 8601308
Yeast. 1998 Jul;14(10):953-61
pubmed: 9717241
Genes Dev. 1997 Jul 1;11(13):1640-50
pubmed: 9224714
Nat Commun. 2017 Mar 07;8:14678
pubmed: 28266506
Annu Rev Biochem. 2013;82:81-118
pubmed: 23642229
J Cell Biol. 2014 Aug 18;206(4):509-24
pubmed: 25135934
Mol Cell Biol. 1999 Sep;19(9):6130-9
pubmed: 10454560
Cell. 2002 Oct 18;111(2):163-72
pubmed: 12408861
Annu Rev Biochem. 2001;70:81-120
pubmed: 11395403
Mol Cell. 2010 Nov 12;40(3):444-54
pubmed: 21070970
Chromosoma. 2012 Aug;121(4):341-52
pubmed: 22552438
Chromosoma. 1985;92(4):290-6
pubmed: 2994966
J Mol Biol. 1999 Dec 17;294(5):1311-25
pubmed: 10600387
J Biol Chem. 2000 Apr 28;275(17):13007-11
pubmed: 10777603
Science. 2013 May 31;340(6136):1110-3
pubmed: 23723239
Mol Gen Genet. 1984;197(2):345-6
pubmed: 6394957
Mol Cell Biol. 1999 Oct;19(10):6621-31
pubmed: 10490601
Mol Biol Cell. 2013 Jun;24(12):2034-44
pubmed: 23637466
FEMS Yeast Res. 2017 Jan 1;17(1):
pubmed: 28158539
Nat Genet. 1996 Sep;14(1):42-9
pubmed: 8782818
J Cell Sci. 2009 Nov 1;122(Pt 21):3831-6
pubmed: 19889968
Nature. 1999 Jun 3;399(6735):491-6
pubmed: 10365964
Mol Microbiol. 1999 Jan;31(1):349-60
pubmed: 9987135
Nature. 2002 Jan 10;415(6868):141-7
pubmed: 11805826
J Cell Sci. 2012 Dec 15;125(Pt 24):5927-36
pubmed: 23418356
J Cell Biol. 2001 Jan 22;152(2):349-60
pubmed: 11266451
EMBO Rep. 2012 Mar 01;13(3):216-22
pubmed: 22322944
EMBO J. 2017 Dec 1;36(23):3458-3482
pubmed: 29046335
Trends Biochem Sci. 2013 Nov;38(11):546-55
pubmed: 24035451
Genetics. 1997 Apr;145(4):923-34
pubmed: 9093847
FEMS Yeast Res. 2018 Feb 1;18(1):
pubmed: 29272409
Elife. 2014 May 20;3:e02203
pubmed: 24844245
Genetics. 1989 May;122(1):19-27
pubmed: 2659436
Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9029-34
pubmed: 22615363
Genes Dev. 1995 Mar 1;9(5):573-86
pubmed: 7698647
Cell. 1998 Sep 4;94(5):607-13
pubmed: 9741625
Genes Dev. 2000 May 15;14(10):1196-208
pubmed: 10817755
EMBO J. 2010 Feb 17;29(4):717-26
pubmed: 20094031
J Cell Biol. 2017 Nov 6;216(11):3551-3570
pubmed: 28939613
Anal Biochem. 2004 Sep 15;332(2):261-73
pubmed: 15325294
Nat Cell Biol. 2006 May;8(5):446-57
pubmed: 16622420
J Cell Biol. 1999 Apr 5;145(1):15-28
pubmed: 10189365
Protein Expr Purif. 2005 May;41(1):207-34
pubmed: 15915565
Mol Cell. 2010 Nov 12;40(3):455-64
pubmed: 21070971
J Cell Biol. 2001 Dec 24;155(7):1147-57
pubmed: 11756469