GLP-1 Receptor in Pancreatic α-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner.


Journal

Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763

Informations de publication

Date de publication:
01 2019
Historique:
received: 15 03 2018
accepted: 15 10 2018
pubmed: 6 11 2018
medline: 26 3 2019
entrez: 4 11 2018
Statut: ppublish

Résumé

Glucagon-like peptide 1 (GLP-1) is known to suppress glucagon secretion, but the mechanism by which GLP-1 exerts this effect is unclear. In this study, we demonstrated GLP-1 receptor (GLP-1R) expression in α-cells using both antibody-dependent and antibody-independent strategies. A novel α-cell-specific GLP-1R knockout (αGLP-1R

Identifiants

pubmed: 30389749
pii: db18-0317
doi: 10.2337/db18-0317
pmc: PMC6302540
doi:

Substances chimiques

Glucagon-Like Peptide-1 Receptor 0
Glucagon 9007-92-5
Glucose IY9XDZ35W2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

34-44

Subventions

Organisme : BLRD VA
ID : I01 BX003725
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK074970
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM104940
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK107412
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK081463
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK107444
Pays : United States

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2018 by the American Diabetes Association.

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Auteurs

Yanqing Zhang (Y)

Section of Endocrinology, Department of Medicine, Tulane University Health Science Center, New Orleans, LA.

Keshab R Parajuli (KR)

Section of Endocrinology, Department of Medicine, Tulane University Health Science Center, New Orleans, LA.

Genevieve E Fava (GE)

Section of Endocrinology, Department of Medicine, Tulane University Health Science Center, New Orleans, LA.

Rajesh Gupta (R)

Section of Endocrinology, Department of Medicine, Tulane University Health Science Center, New Orleans, LA.

Weiwei Xu (W)

Section of Endocrinology, Department of Medicine, Tulane University Health Science Center, New Orleans, LA.

Lauren U Nguyen (LU)

Section of Endocrinology, Department of Medicine, Tulane University Health Science Center, New Orleans, LA.

Anadil F Zakaria (AF)

Section of Endocrinology, Department of Medicine, Tulane University Health Science Center, New Orleans, LA.

Vivian A Fonseca (VA)

Section of Endocrinology, Department of Medicine, Tulane University Health Science Center, New Orleans, LA.

Hongjun Wang (H)

Department of Surgery, Medical University of South Carolina, Charleston, SC.

Franck Mauvais-Jarvis (F)

Section of Endocrinology, Department of Medicine, Tulane University Health Science Center, New Orleans, LA.
Southeast Louisiana Veterans Healthcare Medical Center, New Orleans, LA.

Kyle W Sloop (KW)

Diabetes and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN.

Hongju Wu (H)

Section of Endocrinology, Department of Medicine, Tulane University Health Science Center, New Orleans, LA hwu3@tulane.edu.

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Classifications MeSH