Kyle W Sloop

Publications (31)

GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice.

The Journal of clinical investigation

Avec: Ricardo J Samms , Michael E Christe , Kyla Al Collins , Valentina Pirro , Brian A Droz , Adrienne K Holland , Jessica L Friedrich , Samantha Wojnicki , Debra L Konkol , Richard Cosgrove , Ellen Ps Conceição Furber , Xiaoping Ruan , Libbey S O'Farrell , Annie M Long , Mridula Dogra , Jill A Willency , Yanzhu Lin , Liyun Ding , Christine C Cheng , Over Cabrera , Daniel A Briere , Jorge Alsina-Fernandez , Ruth E Gimeno , Julie S Moyers , Tamer Coskun , Matthew P Coghlan , Kyle W Sloop , William C Roell

Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Takahiro Kawai , Bingfa Sun , Hitoshi Yoshino , Dan Feng , Yoshiyuki Suzuki , Masanori Fukazawa , Shunsuke Nagao , David B Wainscott , Aaron D Showalter , Brian A Droz , Tong Sun Kobilka , Matthew P Coghlan , Francis S Willard , Yoshiki Kawabe , Brian K Kobilka , Kyle W Sloop

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist.

JCI insight

Avec: Francis S Willard , Jonathan D Douros , Maria Bn Gabe , Aaron D Showalter , David B Wainscott , Todd M Suter , Megan E Capozzi , Wijnand Jc van der Velden , Cynthia Stutsman , Guemalli R Cardona , Shweta Urva , Paul J Emmerson , Jens J Holst , David A D'Alessio , Matthew P Coghlan , Mette M Rosenkilde , Jonathan E Campbell , Kyle W Sloop

The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition.

Diabetes

Avec: Megan E Capozzi , Reilly W Coch , Jepchumba Koech , Inna I Astapova , Jacob B Wait , Sara E Encisco , Jonathan D Douros , Kimberly El , Brian Finan , Kyle W Sloop , Mark A Herman , David A D'Alessio , Jonathan E Campbell

How May GIP Enhance the Therapeutic Efficacy of GLP-1?

Trends in endocrinology and metabolism: TEM

Avec: Ricardo J Samms , Matthew P Coghlan , Kyle W Sloop

GIPR Agonism Inhibits PYY-Induced Nausea-Like Behavior.

Diabetes

Avec: Ricardo J Samms , Richard Cosgrove , Brandy M Snider , Ellen C Furber , Brian A Droz , Daniel A Briere , James Dunbar , Mridula Dogra , Jorge Alsina-Fernandez , Tito Borner , Bart C De Jonghe , Matthew R Hayes , Tamer Coskun , Kyle W Sloop , Paul J Emmerson , Minrong Ai

Orforglipron (LY3502970), a novel, oral non-peptide glucagon-like peptide-1 receptor agonist: A Phase 1a, blinded, placebo-controlled, randomized, single- and multiple-ascending-dose study in healthy participants.

Diabetes, obesity & metabolism

Avec: Edward Pratt , Xiaosu Ma , Rong Liu , Deborah Robins , Axel Haupt , Tamer Coskun , Kyle W Sloop , Charles Benson

Compound 18 Improves Glucose Tolerance in a Hepatocyte TGR5-dependent Manner in Mice.

Nutrients

Avec: Marlena M Holter , Margot K Chirikjian , Daniel A Briere , Adriano Maida , Kyle W Sloop , Kristina Schoonjans , Bethany P Cummings

Effect of Food Consumption on the Pharmacokinetics, Safety, and Tolerability of Once-Daily Orally Administered Orforglipron (LY3502970), a Non-peptide GLP-1 Receptor Agonist.

Diabetes therapy : research, treatment and education of diabetes and related disorders

Avec: Xiaosu Ma , Rong Liu , Edward J Pratt , Charles T Benson , Shobha N Bhattachar , Kyle W Sloop

LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept.

Cell metabolism

Avec: Tamer Coskun , Shweta Urva , William C Roell , Hongchang Qu , Corina Loghin , Julie S Moyers , Libbey S O'Farrell , Daniel A Briere , Kyle W Sloop , Melissa K Thomas , Valentina Pirro , David B Wainscott , Francis S Willard , Matthew Abernathy , LaRonda Morford , Yu Du , Charles Benson , Ruth E Gimeno , Axel Haupt , Zvonko Milicevic

The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets.

Nature metabolism

Avec: Kimberley El , Jonathan D Douros , Francis S Willard , Aaron Novikoff , Ashot Sargsyan , Diego Perez-Tilve , David B Wainscott , Bin Yang , Alex Chen , Donald Wothe , Callum Coupland , Mattias H Tschöp , Brian Finan , David A D'Alessio , Kyle W Sloop , Timo D Müller , Jonathan E Campbell

Pancreatic islet α cell function and proliferation requires the arginine transporter SLC7A2.

bioRxiv : the preprint server for biology

Avec: Erick Spears , Jade E Stanley , Matthew Shou , Linlin Yin , Xuan Li , Chunhua Dai , Amber Bradley , Katelyn Sellick , Greg Poffenberger , Katie C Coate , Shristi Shrestha , Regina Jenkins , Kyle W Sloop , Keith T Wilson , Alan D Attie , Mark P Keller , Wenbiao Chen , Alvin C Powers , E Danielle Dean

Discordance between GLP-1R gene and protein expression in mouse pancreatic islet cells.

The Journal of biological chemistry

Avec: Sarah M Gray , Yurong Xin , Elizabeth C Ross , Bryanna M Chazotte , Megan E Capozzi , Kimberley El , Berit Svendsen , Peter Ravn , Kyle W Sloop , Jenny Tong , Jesper Gromada , Jonathan E Campbell , David A D'Alessio

GLP-1 Receptor in Pancreatic α-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner.

Diabetes

Avec: Yanqing Zhang , Keshab R Parajuli , Genevieve E Fava , Rajesh Gupta , Weiwei Xu , Lauren U Nguyen , Anadil F Zakaria , Vivian A Fonseca , Hongjun Wang , Franck Mauvais-Jarvis , Kyle W Sloop , Hongju Wu

Discovery of an Orally Efficacious Positive Allosteric Modulator of the Glucagon-like Peptide-1 Receptor.

Journal of medicinal chemistry

Avec: Francis S Willard , David B Wainscott , Aaron D Showalter , Cynthia Stutsman , Wenzhen Ma , Guemalli R Cardona , Richard W Zink , Christopher M Corkins , Qi Chen , Nathan Yumibe , Javier Agejas , Graham R Cumming , José Miguel Minguez , Alma Jiménez , Ana I Mateo , Ana M Castaño , Daniel A Briere , Kyle W Sloop , Ana B Bueno

GLP-1 receptor signaling increases PCSK1 and β cell features in human α cells.

JCI insight

Avec: Mridusmita Saikia , Marlena M Holter , Leanne R Donahue , Isaac S Lee , Qiaonan C Zheng , Journey L Wise , Jenna E Todero , Daryl J Phuong , Darline Garibay , Reilly Coch , Kyle W Sloop , Adolfo Garcia-Ocana , Charles G Danko , Bethany P Cummings

Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets.

Proceedings of the National Academy of Sciences of the United States of America

Avec: May-Yun Wang , E Danielle Dean , Ezekiel Quittner-Strom , Yi Zhu , Kamrul H Chowdhury , Zhuzhen Zhang , Shangang Zhao , Na Li , Reshing Ye , Young Lee , Yiyi Zhang , Shiuhwei Chen , Xinxin Yu , Derek C Leonard , Greg Poffenberger , Alison Von Deylen , S Kay McCorkle , Amnon Schlegel , Kyle W Sloop , Alexander M Efanov , Ruth E Gimeno , Philipp E Scherer , Alvin C Powers , Roger H Unger , William L Holland

bioRxiv : the preprint server for biology

Avec: Liliane El Eid , Kieran Deane-Alder , Roxana-Maria Rujan , Zamara Mariam , Affiong I Oqua , Yusman Manchanda , Matthew J Belousoff , Jorge Bernardino de la Serna , Kyle W Sloop , Guy A Rutter , Alex Montoya , Dominic J Withers , Steven J Millership , Karim Bouzakri , Ben Jones , Christopher A Reynolds , Patrick M Sexton , Denise Wootten , Giuseppe Deganutti , Alejandra Tomas

Structural insights into probe-dependent positive allosterism of the GLP-1 receptor.

Nature chemical biology

Avec: Ana B Bueno , Bingfa Sun , Francis S Willard , Dan Feng , Joseph D Ho , David B Wainscott , Aaron D Showalter , Michal Vieth , Qi Chen , Cynthia Stutsman , Betty Chau , James Ficorilli , Francisco J Agejas , Graham R Cumming , Alma Jiménez , Isabel Rojo , Tong Sun Kobilka , Brian K Kobilka , Kyle W Sloop

Discovery and pharmacology of the covalent GLP-1 receptor (GLP-1R) allosteric modulator BETP: A novel tool to probe GLP-1R pharmacology.

Advances in pharmacology (San Diego, Calif.)

Avec: Francis S Willard , Joseph D Ho , Kyle W Sloop

GIPR Function in the Central Nervous System: Implications and Novel Perspectives for GIP-Based Therapies in Treating Metabolic Disorders.

Diabetes

Avec: Ricardo J Samms , Kyle W Sloop , Fiona M Gribble , Frank Reimann , Alice E Adriaenssens

Is Glucagon Receptor Activation the Thermogenic Solution for Treating Obesity?

Frontiers in endocrinology

Avec: Ellen Conceição-Furber , Tamer Coskun , Kyle W Sloop , Ricardo J Samms

Orforglipron (LY3502970), a novel, oral non-peptide glucagon-like peptide-1 receptor agonist: A Phase 1b, multicentre, blinded, placebo-controlled, randomized, multiple-ascending-dose study in people with type 2 diabetes.

Diabetes, obesity & metabolism

Avec: Edward Pratt , Xiaosu Ma , Rong Liu , Deborah Robins , Tamer Coskun , Kyle W Sloop , Axel Haupt , Charles Benson

Class B1 GPCRs: Insights into Multi-Receptor Pharmacology for the Treatment of Metabolic Disease.

American journal of physiology. Endocrinology and metabolism

Avec: Panjamaporn Sangwung , Joseph D Ho , Tessa Siddall , Jerry Lin , Alejandra Tomas , Ben Jones , Kyle W Sloop

Activation of the GLP-1 receptor by a non-peptidic agonist.

Nature

Avec: Peishen Zhao , Yi-Lynn Liang , Matthew J Belousoff , Giuseppe Deganutti , Madeleine M Fletcher , Francis S Willard , Michael G Bell , Michael E Christe , Kyle W Sloop , Asuka Inoue , Tin T Truong , Lachlan Clydesdale , Sebastian G B Furness , Arthur Christopoulos , Ming-Wei Wang , Laurence J Miller , Christopher A Reynolds , Radostin Danev , Patrick M Sexton , Denise Wootten

Synthetic protease-activated class B GPCRs.

Biochemical and biophysical research communications

Avec: Francis S Willard , Tamika D Meredith , Aaron D Showalter , Wenzhen Ma , Joseph D Ho , J Michael Sauder , Kyle W Sloop

GIP mediates the incretin effect and glucose tolerance by dual actions on α cells and β cells.

Science advances

Avec: K El , S M Gray , M E Capozzi , E R Knuth , E Jin , B Svendsen , A Clifford , J L Brown , S E Encisco , B M Chazotte , K W Sloop , D J Nunez , M J Merrins , D A D'Alessio , J E Campbell

Structural determinants of dual incretin receptor agonism by tirzepatide.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Bingfa Sun , Francis S Willard , Dan Feng , Jorge Alsina-Fernandez , Qi Chen , Michal Vieth , Joseph D Ho , Aaron D Showalter , Cynthia Stutsman , Liyun Ding , Todd M Suter , James D Dunbar , John W Carpenter , Faiz Ahmad Mohammed , Eitaro Aihara , Robert A Brown , Ana B Bueno , Paul J Emmerson , Julie S Moyers , Tong Sun Kobilka , Matthew P Coghlan , Brian K Kobilka , Kyle W Sloop

GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice.

Diabetes

Avec: Ellen C Furber , Karissa Hyatt , Kyla Collins , Xinxin Yu , Brian A Droz , Adrienne Holland , Jessica L Friedrich , Samantha Wojnicki , Debra L Konkol , Libbey S O'Farrell , Hana E Baker , Tamer Coskun , Philipp E Scherer , Christine M Kusminski , Michael E Christe , Kyle W Sloop , Ricardo J Samms

14-3-3-zeta mediates GLP-1 receptor agonist action to alter α cell proglucagon processing.

Science advances

Avec: Marlena M Holter , Daryl J Phuong , Isaac Lee , Mridusmita Saikia , Lisa Weikert , Samantha Fountain , Elizabeth T Anderson , Qin Fu , Sheng Zhang , Kyle W Sloop , Bethany P Cummings

Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue.

Molecular metabolism

Avec: Ricardo J Samms , GuoFang Zhang , Wentao He , Olga Ilkayeva , Brian A Droz , Steven M Bauer , Cynthia Stutsman , Valentina Pirro , Kyla A Collins , Ellen C Furber , Tamer Coskun , Kyle W Sloop , Joseph T Brozinick , Christopher B Newgard

Réseau de co-auteurs

Francis S Willard 10 collaborations

Tamer Coskun 8 collaborations

Ricardo J Samms 7 collaborations

David B Wainscott 6 collaborations

Aaron D Showalter 6 collaborations

Brian A Droz 5 collaborations

Daniel A Briere 5 collaborations

Matthew P Coghlan 5 collaborations

Cynthia Stutsman 5 collaborations

Joseph D Ho 5 collaborations

David A D'Alessio 4 collaborations

Jonathan E Campbell 4 collaborations

Michael E Christe 3 collaborations

Valentina Pirro 3 collaborations

Libbey S O'Farrell 3 collaborations

Jorge Alsina-Fernandez 3 collaborations

Ruth E Gimeno 3 collaborations

Julie S Moyers 3 collaborations

Bingfa Sun 3 collaborations

Dan Feng 3 collaborations

Tong Sun Kobilka 3 collaborations

Brian K Kobilka 3 collaborations

Jonathan D Douros 3 collaborations

Megan E Capozzi 3 collaborations

Paul J Emmerson 3 collaborations

Ellen C Furber 3 collaborations

Xiaosu Ma 3 collaborations

Rong Liu 3 collaborations

Axel Haupt 3 collaborations

Charles Benson 3 collaborations

Marlena M Holter 3 collaborations

Bethany P Cummings 3 collaborations

Qi Chen 3 collaborations

Ana B Bueno 3 collaborations

Jessica L Friedrich 2 collaborations

Samantha Wojnicki 2 collaborations

Debra L Konkol 2 collaborations

Richard Cosgrove 2 collaborations

Mridula Dogra 2 collaborations

Liyun Ding 2 collaborations

William C Roell 2 collaborations

Todd M Suter 2 collaborations

Guemalli R Cardona 2 collaborations

Shweta Urva 2 collaborations

Brian Finan 2 collaborations

Edward Pratt 2 collaborations

Deborah Robins 2 collaborations

Kimberley El 2 collaborations

Greg Poffenberger 2 collaborations

Alvin C Powers 2 collaborations

E Danielle Dean 2 collaborations

Wenzhen Ma 2 collaborations

Graham R Cumming 2 collaborations

Alma Jiménez 2 collaborations

Mridusmita Saikia 2 collaborations

Daryl J Phuong 2 collaborations

Xinxin Yu 2 collaborations

Philipp E Scherer 2 collaborations

Matthew J Belousoff 2 collaborations

Ben Jones 2 collaborations

Christopher A Reynolds 2 collaborations

Patrick M Sexton 2 collaborations

Denise Wootten 2 collaborations

Giuseppe Deganutti 2 collaborations

Alejandra Tomas 2 collaborations

Michal Vieth 2 collaborations

Kyla Al Collins 1 collaboration

Adrienne K Holland 1 collaboration

Ellen Ps Conceição Furber 1 collaboration

Xiaoping Ruan 1 collaboration

Annie M Long 1 collaboration

Jill A Willency 1 collaboration

Yanzhu Lin 1 collaboration

Christine C Cheng 1 collaboration

Over Cabrera 1 collaboration

Takahiro Kawai 1 collaboration

Hitoshi Yoshino 1 collaboration

Yoshiyuki Suzuki 1 collaboration

Masanori Fukazawa 1 collaboration

Shunsuke Nagao 1 collaboration

Yoshiki Kawabe 1 collaboration

Maria Bn Gabe 1 collaboration

Wijnand Jc van der Velden 1 collaboration

Jens J Holst 1 collaboration

Mette M Rosenkilde 1 collaboration

Reilly W Coch 1 collaboration

Jepchumba Koech 1 collaboration

Inna I Astapova 1 collaboration

Jacob B Wait 1 collaboration

Sara E Encisco 1 collaboration

Kimberly El 1 collaboration

Mark A Herman 1 collaboration

Brandy M Snider 1 collaboration

James Dunbar 1 collaboration

Tito Borner 1 collaboration

Bart C De Jonghe 1 collaboration

Matthew R Hayes 1 collaboration

Minrong Ai 1 collaboration

Margot K Chirikjian 1 collaboration

Adriano Maida 1 collaboration

Kristina Schoonjans 1 collaboration

Edward J Pratt 1 collaboration

Charles T Benson 1 collaboration

Shobha N Bhattachar 1 collaboration

Hongchang Qu 1 collaboration

Corina Loghin 1 collaboration

Melissa K Thomas 1 collaboration

Matthew Abernathy 1 collaboration

LaRonda Morford 1 collaboration

Yu Du 1 collaboration

Zvonko Milicevic 1 collaboration

Aaron Novikoff 1 collaboration

Ashot Sargsyan 1 collaboration

Diego Perez-Tilve 1 collaboration

Bin Yang 1 collaboration

Alex Chen 1 collaboration

Donald Wothe 1 collaboration

Callum Coupland 1 collaboration

Mattias H Tschöp 1 collaboration

Timo D Müller 1 collaboration

Erick Spears 1 collaboration

Jade E Stanley 1 collaboration

Matthew Shou 1 collaboration

Linlin Yin 1 collaboration

Xuan Li 1 collaboration

Chunhua Dai 1 collaboration

Amber Bradley 1 collaboration

Katelyn Sellick 1 collaboration

Katie C Coate 1 collaboration

Shristi Shrestha 1 collaboration

Regina Jenkins 1 collaboration

Keith T Wilson 1 collaboration

Alan D Attie 1 collaboration

Mark P Keller 1 collaboration

Wenbiao Chen 1 collaboration

Sarah M Gray 1 collaboration

Yurong Xin 1 collaboration

Elizabeth C Ross 1 collaboration

Bryanna M Chazotte 1 collaboration

Berit Svendsen 1 collaboration

Peter Ravn 1 collaboration

Jenny Tong 1 collaboration

Jesper Gromada 1 collaboration

Yanqing Zhang 1 collaboration

Keshab R Parajuli 1 collaboration

Genevieve E Fava 1 collaboration

Rajesh Gupta 1 collaboration

Weiwei Xu 1 collaboration

Lauren U Nguyen 1 collaboration

Anadil F Zakaria 1 collaboration

Vivian A Fonseca 1 collaboration

Hongjun Wang 1 collaboration

Franck Mauvais-Jarvis 1 collaboration

Hongju Wu 1 collaboration

Richard W Zink 1 collaboration

Christopher M Corkins 1 collaboration

Nathan Yumibe 1 collaboration

Javier Agejas 1 collaboration

José Miguel Minguez 1 collaboration

Ana I Mateo 1 collaboration

Ana M Castaño 1 collaboration

Leanne R Donahue 1 collaboration

Isaac S Lee 1 collaboration

Qiaonan C Zheng 1 collaboration

Journey L Wise 1 collaboration

Jenna E Todero 1 collaboration

Darline Garibay 1 collaboration

Reilly Coch 1 collaboration

Adolfo Garcia-Ocana 1 collaboration

Charles G Danko 1 collaboration

May-Yun Wang 1 collaboration

Ezekiel Quittner-Strom 1 collaboration

Yi Zhu 1 collaboration

Kamrul H Chowdhury 1 collaboration

Zhuzhen Zhang 1 collaboration

Shangang Zhao 1 collaboration

Na Li 1 collaboration

Reshing Ye 1 collaboration

Young Lee 1 collaboration

Yiyi Zhang 1 collaboration

Shiuhwei Chen 1 collaboration

Derek C Leonard 1 collaboration

Alison Von Deylen 1 collaboration

S Kay McCorkle 1 collaboration

Amnon Schlegel 1 collaboration

Alexander M Efanov 1 collaboration

Roger H Unger 1 collaboration

William L Holland 1 collaboration

Liliane El Eid 1 collaboration

Kieran Deane-Alder 1 collaboration

Roxana-Maria Rujan 1 collaboration

Zamara Mariam 1 collaboration

Affiong I Oqua 1 collaboration

Yusman Manchanda 1 collaboration

Jorge Bernardino de la Serna 1 collaboration

Guy A Rutter 1 collaboration

Alex Montoya 1 collaboration

Dominic J Withers 1 collaboration

Steven J Millership 1 collaboration

Karim Bouzakri 1 collaboration

Betty Chau 1 collaboration

James Ficorilli 1 collaboration

Francisco J Agejas 1 collaboration

Isabel Rojo 1 collaboration

Fiona M Gribble 1 collaboration

Frank Reimann 1 collaboration

Alice E Adriaenssens 1 collaboration

Ellen Conceição-Furber 1 collaboration

Panjamaporn Sangwung 1 collaboration

Tessa Siddall 1 collaboration

Jerry Lin 1 collaboration

Peishen Zhao 1 collaboration

Yi-Lynn Liang 1 collaboration

Madeleine M Fletcher 1 collaboration

Michael G Bell 1 collaboration

Asuka Inoue 1 collaboration

Tin T Truong 1 collaboration

Lachlan Clydesdale 1 collaboration

Sebastian G B Furness 1 collaboration

Arthur Christopoulos 1 collaboration

Ming-Wei Wang 1 collaboration

Laurence J Miller 1 collaboration

Radostin Danev 1 collaboration

Tamika D Meredith 1 collaboration

J Michael Sauder 1 collaboration

K El 1 collaboration

S M Gray 1 collaboration

M E Capozzi 1 collaboration

E R Knuth 1 collaboration

E Jin 1 collaboration

B Svendsen 1 collaboration

A Clifford 1 collaboration

J L Brown 1 collaboration

S E Encisco 1 collaboration

B M Chazotte 1 collaboration

K W Sloop 1 collaboration

D J Nunez 1 collaboration

M J Merrins 1 collaboration

D A D'Alessio 1 collaboration

J E Campbell 1 collaboration

James D Dunbar 1 collaboration

John W Carpenter 1 collaboration

Faiz Ahmad Mohammed 1 collaboration

Eitaro Aihara 1 collaboration

Robert A Brown 1 collaboration

Karissa Hyatt 1 collaboration

Kyla Collins 1 collaboration

Adrienne Holland 1 collaboration

Hana E Baker 1 collaboration

Christine M Kusminski 1 collaboration

Isaac Lee 1 collaboration

Lisa Weikert 1 collaboration

Samantha Fountain 1 collaboration

Elizabeth T Anderson 1 collaboration

Qin Fu 1 collaboration

Sheng Zhang 1 collaboration

GuoFang Zhang 1 collaboration

Wentao He 1 collaboration

Olga Ilkayeva 1 collaboration

Steven M Bauer 1 collaboration

Kyla A Collins 1 collaboration

Joseph T Brozinick 1 collaboration

Christopher B Newgard 1 collaboration