Arthur Christopoulos

Affiliations

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

Publications (20)

Activation of the GLP-1 receptor by a non-peptidic agonist.

Nature

Avec: Peishen Zhao , Yi-Lynn Liang , Matthew J Belousoff , Giuseppe Deganutti , Madeleine M Fletcher , Francis S Willard , Michael G Bell , Michael E Christe , Kyle W Sloop , Asuka Inoue , Tin T Truong , Lachlan Clydesdale , Sebastian G B Furness , Ming-Wei Wang , Laurence J Miller , Christopher A Reynolds , Radostin Danev , Patrick M Sexton , Denise Wootten

Crystal structure of the M

Proceedings of the National Academy of Sciences of the United States of America

Avec: Ziva Vuckovic , Patrick R Gentry , Alice E Berizzi , Kunio Hirata , Swapna Varghese , Geoff Thompson , Emma T van der Westhuizen , Wessel A C Burger , Raphaël Rahmani , Celine Valant , Christopher J Langmead , Craig W Lindsley , Jonathan B Baell , Andrew B Tobin , Patrick M Sexton , David M Thal

Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon.

Cellular and molecular gastroenterology and hepatology

Avec: Jesse J DiCello , Simona E Carbone , Ayame Saito , Pradeep Rajasekhar , Rhian A Ceredig , Vi Pham , Celine Valant , Nicholas A Veldhuis , Meritxell Canals , Dominique Massotte , Daniel P Poole

Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole.

ACS chemical biology

Avec: Carmen Klein Herenbrink , Ravi Verma , Herman D Lim , Anitha Kopinathan , Alastair Keen , Jeremy Shonberg , Christopher J Draper-Joyce , Peter J Scammells , Jonathan A Javitch , Ben Capuano , Lei Shi , J Robert Lane

Subtle Modifications to the Indole-2-carboxamide Motif of the Negative Allosteric Modulator N-(( trans)-4-(2-(7-Cyano-3,4-dihydroisoquinolin-2(1 H)-yl)ethyl)cyclohexyl)-1 H-indole-2-carboxamide (SB269652) Yield Dramatic Changes in Pharmacological Activity at the Dopamine D

Journal of medicinal chemistry

Avec: Anitha Kopinathan , Christopher Draper-Joyce , Monika Szabo , Peter J Scammells , J Robert Lane , Ben Capuano

Reconstruction of medium-size defects of the oral cavity: radial forearm free flap vs facial artery musculo-mucosal flap.

Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale

Avec: Badr Ibrahim , Akram Rahal , Eric Bissada , Apostolos Christopoulos , Louis Guertin , Tareck Ayad

Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation.

Nature communications

Avec: Giuseppe Deganutti , Yi-Lynn Liang , Xin Zhang , Maryam Khoshouei , Lachlan Clydesdale , Matthew J Belousoff , Hari Venugopal , Tin T Truong , Alisa Glukhova , Andrew N Keller , Karen J Gregory , Katie Leach , Radostin Danev , Christopher A Reynolds , Peishen Zhao , Patrick M Sexton , Denise Wootten

Development, translation, and preliminary validation of the neck dissection assessment tool.

Head & neck

Avec: Nathan Yang , Érika Mercier , Louis Guertin , Eric Bissada , Apostolos Christopoulos , Marie-Jo Olivier , Jean-Claude Tabet , Carlos Miguel Chiesa-Estomba , Tareck Ayad

Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.

Molecular cell

Avec: Xin Zhang , Matthew J Belousoff , Peishen Zhao , Albert J Kooistra , Tin T Truong , Sheng Yu Ang , Christina Rye Underwood , Thomas Egebjerg , Petr Šenel , Gregory D Stewart , Yi-Lynn Liang , Alisa Glukhova , Hari Venugopal , Sebastian G B Furness , Laurence J Miller , Steffen Reedtz-Runge , Christopher J Langmead , David E Gloriam , Radostin Danev , Patrick M Sexton , Denise Wootten

Structure and dynamics of the CGRP receptor in apo and peptide-bound forms.

Science (New York, N.Y.)

Avec: Tracy M Josephs , Matthew J Belousoff , Yi-Lynn Liang , Sarah J Piper , Jianjun Cao , Daniel J Garama , Katie Leach , Karen J Gregory , Debbie L Hay , Radostin Danev , Denise Wootten , Patrick M Sexton

Positive allosteric mechanisms of adenosine A

Nature

Avec: Christopher J Draper-Joyce , Rebecca Bhola , Jinan Wang , Apurba Bhattarai , Anh T N Nguyen , India Cowie-Kent , Kelly O'Sullivan , Ling Yeong Chia , Hariprasad Venugopal , Celine Valant , David M Thal , Denise Wootten , Nicolas Panel , Jens Carlsson , Macdonald J Christie , Paul J White , Peter Scammells , Lauren T May , Patrick M Sexton , Radostin Danev , Yinglong Miao , Alisa Glukhova , Wendy L Imlach ,

Understanding VPAC receptor family peptide binding and selectivity.

Nature communications

Avec: Sarah J Piper , Giuseppe Deganutti , Jessica Lu , Peishen Zhao , Yi-Lynn Liang , Yao Lu , Madeleine M Fletcher , Mohammed Akhter Hossain , Christopher A Reynolds , Radostin Danev , Patrick M Sexton , Denise Wootten

Preoperative evaluation of depth of invasion in oral tongue squamous cell carcinoma: A systematic review and meta-analysis.

Oral oncology

Avec: Béatrice Voizard , Michel Khoury , Nadim Saydy , Kristoff Nelson , Guillaume B Cardin , Laurent Létourneau-Guillon , Abdelali Filali-Mouhim , Apostolos Christopoulos

Oncologic Significance of Therapeutic Delays in Patients With Oral Cavity Cancer.

JAMA otolaryngology-- head & neck surgery

Avec: Gabriel S Dayan , Houda Bahig , Stephanie Johnson-Obaseki , Antoine Eskander , Xinyuan Hong , Shamir Chandarana , John R de Almeida , Anthony C Nichols , Michael Hier , Mathieu Belzile , Marc Gaudet , Joseph Dort , T Wayne Matthews , Robert Hart , David P Goldstein , Christopher M K L Yao , Ali Hosni , Danielle MacNeil , James Fowler , Kevin Higgins , Carlos Khalil , Mark Khoury , Alex M Mlynarek , Gregoire Morand , Khalil Sultanem , Anastasios Maniakas , Tareck Ayad , Apostolos Christopoulos

Spatiotemporal Patterns of Reptile and Amphibian Road Fatalities in a Natura 2000 Area: A 12-Year Monitoring of the Lake Karla Mediterranean Wetland.

Animals : an open access journal from MDPI

Avec: Alexandros D Kouris , Apostolos Christopoulos , Konstantinos Vlachopoulos , Aikaterini Christopoulou , Panayiotis G Dimitrakopoulos , Yiannis G Zevgolis

Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein.

Biochemistry

Avec: Jianjun Cao , Matthew J Belousoff , Radostin Danev , Denise Wootten , Patrick M Sexton

Positive allosteric modulation of a GPCR ternary complex.

Science advances

Avec: Wessel A C Burger , Christopher J Draper-Joyce , Celine Valant , David M Thal

Development of Novel 4-Arylpyridin-2-one and 6-Arylpyrimidin-4-one Positive Allosteric Modulators of the M

ChemMedChem

Avec: Manuela Jörg , Elham Khajehali , Emma T van der Westhuizen , K H C Choy , David M Shackleford , Andrew B Tobin , Patrick M Sexton , Celine Valant , Ben Capuano , Peter J Scammells

Dual Inhibition of Autophagy and PI3K/AKT/MTOR Pathway as a Therapeutic Strategy in Head and Neck Squamous Cell Carcinoma.

Cancers

Avec: Monique Bernard , Guillaume B Cardin , Maxime Cahuzac , Tareck Ayad , Eric Bissada , Louis Guertin , Houda Bahig , Phuc Felix Nguyen-Tan , Edith Filion , Olivier Ballivy , Denis Soulieres , Francis Rodier , Apostolos Christopoulos

Evaluation of Operational Models of Agonism and Allosterism at Receptors with Multiple Orthosteric Binding Sites.

Molecular pharmacology

Avec: Karen J Gregory , Jesús Giraldo , Jiayin Diao , Katie Leach

Réseau de co-auteurs

Patrick M Sexton 9 collaborations

Radostin Danev 7 collaborations

Denise Wootten 7 collaborations

Apostolos Christopoulos 6 collaborations

Yi-Lynn Liang 5 collaborations

Matthew J Belousoff 5 collaborations

Celine Valant 5 collaborations

Peishen Zhao 4 collaborations

Tareck Ayad 4 collaborations

Giuseppe Deganutti 3 collaborations

Tin T Truong 3 collaborations

Christopher A Reynolds 3 collaborations

David M Thal 3 collaborations

Christopher J Draper-Joyce 3 collaborations

Peter J Scammells 3 collaborations

Ben Capuano 3 collaborations

Eric Bissada 3 collaborations

Louis Guertin 3 collaborations

Alisa Glukhova 3 collaborations

Karen J Gregory 3 collaborations

Katie Leach 3 collaborations

Madeleine M Fletcher 2 collaborations

Lachlan Clydesdale 2 collaborations

Sebastian G B Furness 2 collaborations

Laurence J Miller 2 collaborations

Emma T van der Westhuizen 2 collaborations

Wessel A C Burger 2 collaborations

Christopher J Langmead 2 collaborations

Andrew B Tobin 2 collaborations

Anitha Kopinathan 2 collaborations

J Robert Lane 2 collaborations

Xin Zhang 2 collaborations

Hari Venugopal 2 collaborations

Sarah J Piper 2 collaborations

Jianjun Cao 2 collaborations

Guillaume B Cardin 2 collaborations

Houda Bahig 2 collaborations

Francis S Willard 1 collaboration

Michael G Bell 1 collaboration

Michael E Christe 1 collaboration

Kyle W Sloop 1 collaboration

Asuka Inoue 1 collaboration

Ming-Wei Wang 1 collaboration

Ziva Vuckovic 1 collaboration

Patrick R Gentry 1 collaboration

Alice E Berizzi 1 collaboration

Kunio Hirata 1 collaboration

Swapna Varghese 1 collaboration

Geoff Thompson 1 collaboration

Raphaël Rahmani 1 collaboration

Craig W Lindsley 1 collaboration

Jonathan B Baell 1 collaboration

Jesse J DiCello 1 collaboration

Simona E Carbone 1 collaboration

Ayame Saito 1 collaboration

Pradeep Rajasekhar 1 collaboration

Rhian A Ceredig 1 collaboration

Vi Pham 1 collaboration

Nicholas A Veldhuis 1 collaboration

Meritxell Canals 1 collaboration

Dominique Massotte 1 collaboration

Daniel P Poole 1 collaboration

Carmen Klein Herenbrink 1 collaboration

Ravi Verma 1 collaboration

Herman D Lim 1 collaboration

Alastair Keen 1 collaboration

Jeremy Shonberg 1 collaboration

Jonathan A Javitch 1 collaboration

Lei Shi 1 collaboration

Christopher Draper-Joyce 1 collaboration

Monika Szabo 1 collaboration

Badr Ibrahim 1 collaboration

Akram Rahal 1 collaboration

Maryam Khoshouei 1 collaboration

Andrew N Keller 1 collaboration

Nathan Yang 1 collaboration

Érika Mercier 1 collaboration

Marie-Jo Olivier 1 collaboration

Jean-Claude Tabet 1 collaboration

Carlos Miguel Chiesa-Estomba 1 collaboration

Albert J Kooistra 1 collaboration

Sheng Yu Ang 1 collaboration

Christina Rye Underwood 1 collaboration

Thomas Egebjerg 1 collaboration

Petr Šenel 1 collaboration

Gregory D Stewart 1 collaboration

Steffen Reedtz-Runge 1 collaboration

David E Gloriam 1 collaboration

Tracy M Josephs 1 collaboration

Daniel J Garama 1 collaboration

Debbie L Hay 1 collaboration

Rebecca Bhola 1 collaboration

Jinan Wang 1 collaboration

Apurba Bhattarai 1 collaboration

Anh T N Nguyen 1 collaboration

India Cowie-Kent 1 collaboration

Kelly O'Sullivan 1 collaboration

Ling Yeong Chia 1 collaboration

Hariprasad Venugopal 1 collaboration

Nicolas Panel 1 collaboration

Jens Carlsson 1 collaboration

Macdonald J Christie 1 collaboration

Paul J White 1 collaboration

Peter Scammells 1 collaboration

Lauren T May 1 collaboration

Yinglong Miao 1 collaboration

Wendy L Imlach 1 collaboration

Jessica Lu 1 collaboration

Yao Lu 1 collaboration

Mohammed Akhter Hossain 1 collaboration

Béatrice Voizard 1 collaboration

Michel Khoury 1 collaboration

Nadim Saydy 1 collaboration

Kristoff Nelson 1 collaboration

Laurent Létourneau-Guillon 1 collaboration

Abdelali Filali-Mouhim 1 collaboration

Gabriel S Dayan 1 collaboration

Stephanie Johnson-Obaseki 1 collaboration

Antoine Eskander 1 collaboration

Xinyuan Hong 1 collaboration

Shamir Chandarana 1 collaboration

John R de Almeida 1 collaboration

Anthony C Nichols 1 collaboration

Michael Hier 1 collaboration

Mathieu Belzile 1 collaboration

Marc Gaudet 1 collaboration

Joseph Dort 1 collaboration

T Wayne Matthews 1 collaboration

Robert Hart 1 collaboration

David P Goldstein 1 collaboration

Christopher M K L Yao 1 collaboration

Ali Hosni 1 collaboration

Danielle MacNeil 1 collaboration

James Fowler 1 collaboration

Kevin Higgins 1 collaboration

Carlos Khalil 1 collaboration

Mark Khoury 1 collaboration

Alex M Mlynarek 1 collaboration

Gregoire Morand 1 collaboration

Khalil Sultanem 1 collaboration

Anastasios Maniakas 1 collaboration

Alexandros D Kouris 1 collaboration

Konstantinos Vlachopoulos 1 collaboration

Aikaterini Christopoulou 1 collaboration

Panayiotis G Dimitrakopoulos 1 collaboration

Yiannis G Zevgolis 1 collaboration

Manuela Jörg 1 collaboration

Elham Khajehali 1 collaboration

K H C Choy 1 collaboration

David M Shackleford 1 collaboration

Monique Bernard 1 collaboration

Maxime Cahuzac 1 collaboration

Phuc Felix Nguyen-Tan 1 collaboration

Edith Filion 1 collaboration

Olivier Ballivy 1 collaboration

Denis Soulieres 1 collaboration

Francis Rodier 1 collaboration

Jesús Giraldo 1 collaboration

Jiayin Diao 1 collaboration