Discordance between GLP-1R gene and protein expression in mouse pancreatic islet cells.
G protein–coupled receptor (GPCR)
GLP-1R antibody
cell sorting
flow cytometry
glucagon-like peptide 1 receptor (GLP-1R)
glucose-dependent insulinotropic polypeptide receptor (GIPR)
heterogeneity
incretin
islet
metabolism
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
14 08 2020
14 08 2020
Historique:
received:
22
05
2020
revised:
16
06
2020
pubmed:
20
6
2020
medline:
20
1
2021
entrez:
20
6
2020
Statut:
ppublish
Résumé
The insulinotropic actions of glucagon-like peptide 1 receptor (GLP-1R) in β-cells have made it a useful target to manage type 2 diabetes. Metabolic stress reduces β-cell sensitivity to GLP-1, yet the underlying mechanisms are unknown. We hypothesized that
Identifiants
pubmed: 32554468
pii: S0021-9258(17)48456-0
doi: 10.1074/jbc.RA120.014368
pmc: PMC7450118
doi:
Substances chimiques
Glucagon-Like Peptide-1 Receptor
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11529-11541Subventions
Organisme : NIDDK NIH HHS
ID : F32 DK116542
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007012
Pays : United States
Organisme : NIDDK NIH HHS
ID : F32 DK121420
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK101991
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK123075
Pays : United States
Informations de copyright
© 2020 Gray et al.
Déclaration de conflit d'intérêts
Conflict of interest—Y. X. and J. G. are currently employed by Vertex Pharmaceuticals. P. R. is an employee of AstraZeneca. K. W. S. is an employee of Eli Lilly. A portion of this work was supported by Eli Lilly and Company through the Lilly Research Award Program (LRAP).
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