Mette M Rosenkilde

Affiliations
  • Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK 2200, Denmark.

Publications (79)

Perspective: Implications of Ligand-Receptor Binding Kinetics for Therapeutic Targeting of G Protein-Coupled Receptors.

ACS pharmacology & translational science
Avec: Wijnand J C van der Velden , Laura H Heitman , Mette M Rosenkilde

The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling.

ACS pharmacology & translational science
Avec: Martha E Sommer , Jana Selent , Jens Carlsson , Chris De Graaf , David E Gloriam , Gyorgy M Keseru , Mickey Kosloff , Stefan Mordalski , Aurelien Rizk , Mette M Rosenkilde , Eddy Sotelo , Johanna K S Tiemann , Andrew Tobin , Nina Vardjan , Maria Waldhoer , Peter Kolb

GIP as a Therapeutic Target in Diabetes and Obesity: Insight From Incretin Co-agonists.

The Journal of clinical endocrinology and metabolism
Avec: Jens Juul Holst , Mette Marie Rosenkilde

Structural Features of an Extended C-Terminal Tail Modulate the Function of the Chemokine CCL21.

Biochemistry
Avec: Natasha A Moussouras , Gertrud M Hjortø , Francis C Peterson , Martyna Szpakowska , Andy Chevigné , Mette M Rosenkilde , Brian F Volkman , Michael B Dwinell

Development of highly efficient protocols for extraction and amplification of cytomegalovirus DNA from dried blood spots for detection and genotyping of polymorphic immunomodulatory genes.

PloS one
Avec: Christian Berg , Martin B Friis , Mette M Rosenkilde , Thomas Benfield , Lene Nielsen , Hans R Lüttichau , Thomas Sundelin

Expression Profile of the GLP-1 Receptor in the Gastrointestinal Tract and Pancreas in Adult Female Mice.

Endocrinology
Avec: Kaare V Grunddal , Elisa P Jensen , Cathrine Ørskov , Daniel B Andersen , Johanne A Windeløv , Steen Seier Poulsen , Mette M Rosenkilde , Lotte Bjerre Knudsen , Charles Pyke , Jens J Holst

L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion.

Frontiers in endocrinology
Avec: Rune E Kuhre , Ida M Modvig , Sara L Jepsen , Hüsün S Kizilkaya , Cecilie Bæch-Laursen , Christopher A Smith , Frank Reimann , Fiona M Gribble , Mette M Rosenkilde , Jens J Holst

Methods for Studying Endocytotic Pathways of Herpesvirus Encoded G Protein-Coupled Receptors.

Molecules (Basel, Switzerland)
Avec: Maša Mavri , Katja Spiess , Mette Marie Rosenkilde , Catrin Sian Rutland , Milka Vrecl , Valentina Kubale

Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization.

Communications biology
Avec: Astrid S Jørgensen , Viktorija Daugvilaite , Katia De Filippo , Christian Berg , Masa Mavri , Tau Benned-Jensen , Goda Juzenaite , Gertrud Hjortø , Sara Rankin , Jon Våbenø , Mette M Rosenkilde

Identification of a conserved chemokine receptor motif that enables ligand discrimination.

Science signaling
Avec: Olav Larsen , Wijnand J C van der Velden , Maša Mavri , Sara Schuermans , Pia C Rummel , Stefanie Karlshøj , Martin Gustavsson , Paul Proost , Jon Våbenø , Mette M Rosenkilde

Glucose-dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet-fed mice.

British journal of pharmacology
Avec: Geke Aline Boer , Jenna Elizabeth Hunt , Maria Buur Nordskov Gabe , Johanne Agerlin Windeløv , Alexander Hovard Sparre-Ulrich , Bolette Hartmann , Jens Juul Holst , Mette Marie Rosenkilde

Glycine: a long-sought novel ligand for GPR158.

Trends in pharmacological sciences
Avec: Mette Marie Rosenkilde , Jesper Mosolff Mathiesen

Effects of exogenous GIP and GLP-2 on bone turnover in individuals with type 2 diabetes.

The Journal of clinical endocrinology and metabolism
Avec: Kirsa Skov-Jeppesen , Charlotte B Christiansen , Laura S Hansen , Johanne A Windeløv , Nora Hedbäck , Lærke S Gasbjerg , Morten Hindsø , Maria S Svane , Sten Madsbad , Jens J Holst , Mette M Rosenkilde , Bolette Hartmann

Amantadine for COVID-19 treatment (ACT) study: a randomized, double-blinded, placebo-controlled clinical trial.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Avec: Nina Weis , Signe Bollerup , Jon Dissing Sund , Jakob Borg Glamann , Caroline Vinten , Louise Riger Jensen , Christoffer Sejling , Thomas Nitschke Kledal , Mette Marie Rosenkilde

GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells.

European journal of endocrinology
Avec: Morten S Hansen , Kent Søe , Line L Christensen , Paula Fernandez-Guerra , Nina W Hansen , Rachael A Wyatt , Claire Martin , Rowan S Hardy , Thomas L Andersen , Jacob B Olesen , Bolette Hartmann , Mette M Rosenkilde , Moustapha Kassem , Alexander Rauch , Caroline M Gorvin , Morten Frost

The naturally occurring GIP(1-30)NH2 is a GIP receptor agonist in humans.

European journal of endocrinology
Avec: Liva S L Krogh , Kristine Henriksen , Signe Stensen , Kirsa Skov-Jeppesen , Natasha C Bergmann , Joachim Størling , Mette M Rosenkilde , Bolette Hartmann , Jens J Holst , Lærke S Gasbjerg , Filip K Knop

L-valine is a powerful stimulator of GLP-1 secretion in rodents and stimulates secretion through ATP-sensitive potassium channels and voltage-gated calcium channels.

Nutrition & diabetes
Avec: Ida Marie Modvig , Mark M Smits , Katrine Douglas Galsgaard , Anna Pii Hjørne , Anna Katarzyna Drzazga , Mette Marie Rosenkilde , Jens Juul Holst

Advancing the field of viroporins-Structure, function and pharmacology: IUPHAR Review X.

British journal of pharmacology
Avec: Kira Devantier , Viktoria M S Kjær , Stephen Griffin , Birthe B Kragelund , Mette M Rosenkilde

Neuromedin U Does Not Act as a Decretin in Rats.

Cell metabolism
Avec: Rune Ehrenreich Kuhre , Charlotte Bayer Christiansen , Seyed Mojtaba Ghiasi , Maria Buur Nordskov Gabe , Patricia Almine Skat-Rørdam , Ida Marie Modvig , Thomas Mandrup-Poulsen , Reidar Albrechtsen , Mette Marie Rosenkilde , Bolette Hartmann , Nicolai Jacob Wewer Albrechtsen , Jens Juul Holst

Three-Dimensional Explant Platform for Studies on Choroid Plexus Epithelium.

Frontiers in cellular neuroscience
Avec: Natalia Petersen , Lola Torz , Kristian H Reveles Jensen , Gertrud Malene Hjortø , Katja Spiess , Mette Marie Rosenkilde

Dose-dependent efficacy of the glucose-dependent insulinotropic polypeptide (GIP) receptor antagonist GIP(3-30)NH

Diabetes, obesity & metabolism
Avec: Laerke Smidt Gasbjerg , Emilie J Bari , Signe Stensen , Bjørn Hoe , Amalie R Lanng , David S Mathiesen , Mikkel B Christensen , Bolette Hartmann , Jens J Holst , Mette M Rosenkilde , Filip Krag Knop

Molecular and in vivo phenotyping of missense variants of the human glucagon receptor.

The Journal of biological chemistry
Avec: Wijnand J C van der Velden , Peter Lindquist , Jakob S Madsen , Roderick H M J Stassen , Nicolai J Wewer Albrechtsen , Jens J Holst , Alexander S Hauser , Mette M Rosenkilde

Ex vivo treatment of cytomegalovirus in human donor lungs using a novel chemokine-based immunotoxin.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Avec: Rafaela V P Ribeiro , Terrance Ku , Aizhou Wang , Layla Pires , Victor H Ferreira , Vinicius Michaelsen , Aadil Ali , Marcos Galasso , Sajad Moshkelgosha , Anajara Gazzalle , Mads G Jeppesen , Mette M Rosenkilde , Mingyao Liu , Lianne G Singer , Deepali Kumar , Shaf Keshavjee , John Sinclair , Thomas N Kledal , Atul Humar , Marcelo Cypel

Investigating GIPR (ant)agonism: A structural analysis of GIP and its receptor.

Structure (London, England : 1993)
Avec: Florent X Smit , Wijnand J C van der Velden , Hüsün S Kizilkaya , Amalie Nørskov , Michael Lückmann , Tobias N Hansen , Alexander H Sparre-Ulrich , Katrine Qvotrup , Thomas M Frimurer , Mette M Rosenkilde

The Dual GLP-1/GIP Receptor Agonist DA4-JC Shows Superior Protective Properties Compared to the GLP-1 Analogue Liraglutide in the APP/PS1 Mouse Model of Alzheimer's Disease.

American journal of Alzheimer's disease and other dementias
Avec: Mark Maskery , Elizabeth Mary Goulding , Simon Gengler , Josefine Ulrikke Melchiorsen , Mette Marie Rosenkilde , Christian Hölscher

The Role of Incretins on Insulin Function and Glucose Homeostasis.

Endocrinology
Avec: Jens Juul Holst , Lærke Smidt Gasbjerg , Mette Marie Rosenkilde

Pharmacological and structure-activity relationship studies of oleoyl-lysophosphatidylinositol synthetic mimetics.

Pharmacological research
Avec: Silvano Paternoster , Peter V Simpson , Elena Kokh , Hüsün Sheyma Kizilkaya , Mette Marie Rosenkilde , Ricardo L Mancera , Damien J Keating , Massimiliano Massi , Marco Falasca

Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats.

Diabetologia
Avec: Kaare V Grunddal , Samuel A J Trammell , Cecilie Bæch-Laursen , Daniel B Andersen , Stella F S Xu , Helle Andersen , Matthew P Gillum , Seyed M Ghiasi , Ivana Novak , Björn Tyrberg , Chien Li , Mette M Rosenkilde , Bolette Hartmann , Jens J Holst , Rune E Kuhre

GLP-1 and GIP receptor signaling in beta cells - A review of receptor interactions and co-stimulation.

Peptides
Avec: Ashok Mayendraraj , Mette M Rosenkilde , Lærke S Gasbjerg

Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling and lymphocyte chemotaxis, while retaining angiostatic activity.

Cell communication and signaling : CCS
Avec: Luna Dillemans , Karen Yu , Alexandra De Zutter , Sam Noppen , Mieke Gouwy , Nele Berghmans , Lisa Verhallen , Mirre De Bondt , Lotte Vanbrabant , Stef Brusselmans , Erik Martens , Dominique Schols , Patrick Verschueren , Mette M Rosenkilde , Pedro Elias Marques , Sofie Struyf , Paul Proost

GPR162 is a beta cell CART receptor.

iScience
Avec: Andreas Lindqvist , Mia Abels , Liliya Shcherbina , Mtakai Ngara , Dmytro Kryvokhyzha , Sabrina Chriett , Matteo Riva , Abul Fajul , Mohammad Barghouth , Cheng Luan , Lena Eliasson , Olav Larsen , Mette M Rosenkilde , Enming Zhang , Erik Renström , Nils Wierup

Rare Heterozygous Loss-of-Function Variants in the Human GLP-1 Receptor Are Not Associated With Cardiometabolic Phenotypes.

The Journal of clinical endocrinology and metabolism
Avec: Josefine U Melchiorsen , Kimmie V Sørensen , Jette Bork-Jensen , Hüsün S Kizilkaya , Lærke S Gasbjerg , Alexander S Hauser , Jørgen Rungby , Henrik T Sørensen , Allan Vaag , Jens S Nielsen , Oluf Pedersen , Allan Linneberg , Bolette Hartmann , Anette P Gjesing , Jens J Holst , Torben Hansen , Mette M Rosenkilde , Niels Grarup

The Secretome of Parental and Bone Metastatic Breast Cancer Elicits Distinct Effects in Human Osteoclast Activity after Activation of β2 Adrenergic Signaling.

Biomolecules
Avec: Francisco Conceição , Daniela M Sousa , Sofia Tojal , Catarina Lourenço , Carina Carvalho-Maia , Helena Estevão-Pereira , João Lobo , Marina Couto , Mette M Rosenkilde , Carmen Jerónimo , Meriem Lamghari

Post-infection treatment with the E protein inhibitor BIT225 reduces disease severity and increases survival of K18-hACE2 transgenic mice infected with a lethal dose of SARS-CoV-2.

PLoS pathogens
Avec: Gary Ewart , Michael Bobardt , Bo Hjorth Bentzen , Yannan Yan , Audrey Thomson , Klaus Klumpp , Stephen Becker , Mette M Rosenkilde , Michelle Miller , Philippe Gallay

Identification of a Salt Bridge That Is Functionally Important for Chemokine Receptor CXCR1 but not CXCR2.

ACS pharmacology & translational science
Avec: Jon Våbenø , Marta Oliva-Santiago , Astrid S Jørgensen , Stefanie Karlshøj , Mette M Rosenkilde

GLP-1 increases heart rate by a direct action on the sinus node.

Cardiovascular research
Avec: Anniek Frederike Lubberding , Simon Veedfald , Jonathan Samuel Achter , Sarah Dalgas Nissen , Luca Soattin , Andrea Sorrentino , Estefania Torres Vega , Benedikt Linz , Caroline Harriet Eggert Eggertsen , John Mulvey , Signe Toräng , Sara Agnete Larsen , Anne Nissen , Lonnie Grove Petersen , Secil Erbil Bilir , Bo Hjorth Bentzen , Mette Marie Rosenkilde , Bolette Hartmann , Thomas Nikolaj Bang Lilleør , Saddiq Qazi , Christian Holdflod Møller , Jacob Tfelt-Hansen , Stefan Michael Sattler , Thomas Jespersen , Jens Juul Holst , Alicia Lundby

Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes.

Nature metabolism
Avec: Hüsün S Kizilkaya , Kimmie V Sørensen , Jakob S Madsen , Peter Lindquist , Jonathan D Douros , Jette Bork-Jensen , Alessandro Berghella , Peter A Gerlach , Lærke S Gasbjerg , Jacek Mokrosiński , Stephanie A Mowery , Patrick J Knerr , Brian Finan , Jonathan E Campbell , David A D'Alessio , Diego Perez-Tilve , Felix Faas , Signe Mathiasen , Jørgen Rungby , Henrik T Sørensen , Allan Vaag , Jens S Nielsen , Jens-Christian Holm , Jeannet Lauenborg , Peter Damm , Oluf Pedersen , Allan Linneberg , Bolette Hartmann , Jens J Holst , Torben Hansen , Shane C Wright , Volker M Lauschke , Niels Grarup , Alexander S Hauser , Mette M Rosenkilde

An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles.

Nature communications
Avec: Thomas D Madsen , Lasse H Hansen , John Hintze , Zilu Ye , Shifa Jebari , Daniel B Andersen , Hiren J Joshi , Tongzhong Ju , Jens P Goetze , Cesar Martin , Mette M Rosenkilde , Jens J Holst , Rune E Kuhre , Christoffer K Goth , Sergey Y Vakhrushev , Katrine T Schjoldager

Rat cytomegalovirus-encoded γ-chemokine vXCL1 is a highly adapted, species-specific agonist for rat XCR1-positive dendritic cells.

Journal of cell science
Avec: Agnieszka Bauer , Julia Madela , Christian Berg , Viktorija Daugvilaite , Stephanie Gurka , Hans Werner Mages , Richard A Kroczek , Mette M Rosenkilde , Sebastian Voigt

Arrestin-independent constitutive endocytosis of GPR125/ADGRA3.

Annals of the New York Academy of Sciences
Avec: Katja Spiess , Sofie O Bagger , Lola J Torz , Kristian H R Jensen , Anna L Walser , Jone M Kvam , Ann-Sofie K Møgelmose , Viktorija Daugvilaite , Riia K Junnila , Gertrud M Hjortø , Mette M Rosenkilde

GLP-2 and GIP exert separate effects on bone turnover: A randomized, placebo-controlled, crossover study in healthy young men.

Bone
Avec: Kirsa Skov-Jeppesen , Maria S Svane , Christoffer Martinussen , Maria B N Gabe , Lærke S Gasbjerg , Simon Veedfald , Kirstine N Bojsen-Møller , Sten Madsbad , Jens J Holst , Mette M Rosenkilde , Bolette Hartmann

Increased Body Weight and Fat Mass After Subchronic GIP Receptor Antagonist, but Not GLP-2 Receptor Antagonist, Administration in Rats.

Frontiers in endocrinology
Avec: Sara Baldassano , Lærke Smidt Gasbjerg , Hüsün Sheyma Kizilkaya , Mette Marie Rosenkilde , Jens Juul Holst , Bolette Hartmann

Separate and Combined Glucometabolic Effects of Endogenous Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like Peptide 1 in Healthy Individuals.

Diabetes
Avec: Lærke S Gasbjerg , Mads M Helsted , Bolette Hartmann , Mette H Jensen , Maria B N Gabe , Alexander H Sparre-Ulrich , Simon Veedfald , Signe Stensen , Amalie R Lanng , Natasha C Bergmann , Mikkel B Christensen , Tina Vilsbøll , Jens J Holst , Mette M Rosenkilde , Filip K Knop

GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats.

ACS pharmacology & translational science
Avec: Wijnand J C van der Velden , Florent X Smit , Charlotte B Christiansen , Thor C Møller , Gertrud M Hjortø , Olav Larsen , Sine P Schiellerup , Hans Bräuner-Osborne , Jens J Holst , Bolette Hartmann , Thomas M Frimurer , Mette M Rosenkilde

A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor.

Cell research
Avec: Wen Sun , Li-Nan Chen , Qingtong Zhou , Li-Hua Zhao , Dehua Yang , Huibing Zhang , Zhaotong Cong , Dan-Dan Shen , Fenghui Zhao , Fulai Zhou , Xiaoqing Cai , Yan Chen , Yan Zhou , Sarina Gadgaard , Wijnand J C van der Velden , Suwen Zhao , Yi Jiang , Mette M Rosenkilde , H Eric Xu , Yan Zhang , Ming-Wei Wang

Estrous Cycle Modulation of Feeding and Relaxin-3/Rxfp3 mRNA Expression: Implications for Estradiol Action.

Neuroendocrinology
Avec: Camila de Ávila , Sandrine Chometton , Juliane Calvez , Geneviève Guèvremont , Alan Kania , Lola Torz , Christophe Lenglos , Anna Blasiak , Mette M Rosenkilde , Birgitte Holst , Cheryl D Conrad , John D Fryer , Elena Timofeeva , Andrew L Gundlach , Carlo Cifani

Loss of Function Glucose-Dependent Insulinotropic Polypeptide Receptor Variants Are Associated With Alterations in BMI, Bone Strength and Cardiovascular Outcomes.

Frontiers in cell and developmental biology
Avec: Hüsün Sheyma Kizilkaya , Kimmie Vestergaard Sørensen , Camilla J Kibsgaard , Laerke Smidt Gasbjerg , Alexander S Hauser , Alexander Hovard Sparre-Ulrich , Niels Grarup , Mette M Rosenkilde

Dendritic Cells and CCR7 Expression: An Important Factor for Autoimmune Diseases, Chronic Inflammation, and Cancer.

International journal of molecular sciences
Avec: Emma Probst Brandum , Astrid Sissel Jørgensen , Mette Marie Rosenkilde , Gertrud Malene Hjortø

Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1.

Immunity
Avec: Naotaka Tsutsumi , Qianhui Qu , Maša Mavri , Maibritt S Baggesen , Shoji Maeda , Deepa Waghray , Christian Berg , Brian K Kobilka , Mette M Rosenkilde , Georgios Skiniotis , K Christopher Garcia

Mutational Landscape of the Proglucagon-Derived Peptides.

Frontiers in endocrinology
Avec: Peter Lindquist , Jakob S Madsen , Hans Bräuner-Osborne , Mette M Rosenkilde , Alexander S Hauser

The non-ELR CXC chemokine encoded by human cytomegalovirus UL146 genotype 5 contains a C-terminal β-hairpin and induces neutrophil migration as a selective CXCR2 agonist.

PLoS pathogens
Avec: Christian Berg , Michael J Wedemeyer , Motiejus Melynis , Roman R Schlimgen , Lasse H Hansen , Jon Våbenø , Francis C Peterson , Brian F Volkman , Mette M Rosenkilde , Hans R Lüttichau

GIP and GLP-2 together improve bone turnover in humans supporting GIPR-GLP-2R co-agonists as future osteoporosis treatment.

Pharmacological research
Avec: Maria Buur Nordskov Gabe , Kirsa Skov-Jeppesen , Lærke Smidt Gasbjerg , Sine Pasch Schiellerup , Christoffer Martinussen , Sarina Gadgaard , Geke Aline Boer , Jannika Oeke , Lola Julia Torz , Simon Veedfald , Maria Saur Svane , Kirstine Nyvold Bojsen-Møller , Sten Madsbad , Jens Juul Holst , Bolette Hartmann , Mette Marie Rosenkilde

Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice.

Molecular metabolism
Avec: Katrine D Galsgaard , Emilie Elmelund , Christian D Johansen , Anna B Bomholt , Hüsün S Kizilkaya , Frederik Ceutz , Jenna E Hunt , Hannelouise Kissow , Marie Winther-Sørensen , Charlotte M Sørensen , Thomas Kruse , Jesper F Lau , Mette M Rosenkilde , Cathrine Ørskov , Christina Christoffersen , Jens J Holst , Nicolai J Wewer Albrechtsen

GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection.

The European respiratory journal
Avec: Cheng Xiang Foo , Stacey Bartlett , Keng Yih Chew , Minh Dao Ngo , Helle Bielefeldt-Ohmann , Buddhika Jayakody Arachchige , Benjamin Matthews , Sarah Reed , Ran Wang , Christian Smith , Matthew J Sweet , Lucy Burr , Kavita Bisht , Svetlana Shatunova , Jane E Sinclair , Rhys Parry , Yuanhao Yang , Jean-Pierre Lévesque , Alexander Khromykh , Mette Marie Rosenkilde , Kirsty R Short , Katharina Ronacher

"Glyco-sulfo barcodes" regulate chemokine receptor function.

Cellular and molecular life sciences : CMLS
Avec: Lisa Verhallen , Jarkko J Lackman , Rikke Wendt , Martin Gustavsson , Zhang Yang , Yoshiki Narimatsu , Daniel M Sørensen , Kato Mac Lafferty , Mieke Gouwy , Pedro E Marques , Gertrud M Hjortø , Mette M Rosenkilde , Paul Proost , Christoffer K Goth

Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Avec: Maja L Nybo , Jone M Kvam , John E Nielsen , Hanne Frederiksen , Katja Spiess , Kristian H R Jensen , Sarina Gadgaard , Anna L S Walser , Jesper S Thomsen , Pamela Cowin , Anders Juul , Martin Blomberg Jensen , Mette M Rosenkilde

Therapeutic targeting of HCMV-encoded chemokine receptor US28: Progress and challenges.

Frontiers in immunology
Avec: Christian Berg , Mette M Rosenkilde

Ligand entry pathways control the chemical space recognized by GPR183.

Chemical science
Avec: Viktoria Madeline Skovgaard Kjær , Tomasz Maciej Stępniewski , Brian Medel-Lacruz , Lisa Reinmuth , Marija Ciba , Elisabeth Rexen Ulven , Massimiliano Bonomi , Jana Selent , Mette Marie Rosenkilde

GIP-derived GIP receptor antagonists - a review of their role in GIP receptor pharmacology.

Peptides
Avec: Mette Marie Rosenkilde , Peter Lindquist , Hüsün Sheyma Kizilkaya , Lærke Smidt Gasbjerg

Alpha-cyclodextrin increases glucagon-like peptide-1 secretion in multiple models and improves metabolic status in mice.

Food chemistry
Avec: Mark M Smits , Liv von Voss , Anna Katarzyna Drzazga , Emily Eufaula Beaman , Annemette Overgaard Brethvad , Jens Juul Holst , Mette Marie Rosenkilde

AT-7687, a novel GIPR peptide antagonist, combined with a GLP-1 agonist, leads to enhanced weight loss and metabolic improvements in cynomolgus monkeys.

Molecular metabolism
Avec: Mette H Jensen , Samra J Sanni , Ditte Riber , Jens J Holst , Mette M Rosenkilde , Alexander H Sparre-Ulrich

G Protein-Coupled Receptors in the Sweet Spot: Glycosylation and other Post-translational Modifications.

ACS pharmacology & translational science
Avec: Christoffer K Goth , Ulla E Petäjä-Repo , Mette M Rosenkilde

Selective Allosteric Modulation of N-Terminally Cleaved, but Not Full Length CCL3 in CCR1.

ACS pharmacology & translational science
Avec: Olav Larsen , Michael Lückmann , Wijnand J C van der Velden , Marta Oliva-Santiago , Matjaz Brvar , Trond Ulven , Thomas M Frimurer , Stefanie Karlshøj , Mette M Rosenkilde

The role of endogenous GIP and GLP-1 in postprandial bone homeostasis.

Bone
Avec: Mads M Helsted , Lærke S Gasbjerg , Amalie R Lanng , Natasha C Bergmann , Signe Stensen , Bolette Hartmann , Mikkel B Christensen , Jens J Holst , Tina Vilsbøll , Mette M Rosenkilde , Filip K Knop

Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7.

Frontiers in immunology
Avec: Astrid S Jørgensen , Olav Larsen , Edith Uetz-von Allmen , Michael Lückmann , Daniel F Legler , Thomas M Frimurer , Christopher T Veldkamp , Gertrud M Hjortø , Mette M Rosenkilde

Physiology of the Incretin Hormones, GIP and GLP-1-Regulation of Release and Posttranslational Modifications.

Comprehensive Physiology
Avec: Jens J Holst , Nicolai J Wewer Albrechtsen , Mette M Rosenkilde , Carolyn F Deacon

Evaluation of the incretin effect in humans using GIP and GLP-1 receptor antagonists.

Peptides
Avec: Lærke S Gasbjerg , Natasha C Bergmann , Signe Stensen , Mikkel B Christensen , Mette M Rosenkilde , Jens J Holst , Michael Nauck , Filip K Knop

Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long-term impairment of the GIP system.

Basic & clinical pharmacology & toxicology
Avec: Maria Buur Nordskov Gabe , Wijnand J C van der Velden , Sarina Gadgaard , Florent Xavier Smit , Bolette Hartmann , Hans Bräuner-Osborne , Mette Marie Rosenkilde

The glucagon receptor antagonist LY2409021 has no effect on postprandial glucose in type 2 diabetes.

European journal of endocrinology
Avec: Sofie Hædersdal , Asger Lund , Henrik Maagensen , Elisabeth Nielsen-Hannerup , Lærke S Gasbjerg , Mette M Rosenkilde , Julie L Forman , Gerrit van Hall , Jens J Holst , Filip K Knop , Tina Vilsbøll

Molecular interactions of full-length and truncated GIP peptides with the GIP receptor - A comprehensive review.

Peptides
Avec: Maria Buur Nordskov Gabe , Wijnand J C van der Velden , Florent Xavier Smit , Lærke Smidt Gasbjerg , Mette Marie Rosenkilde

Enteroendocrine K Cells Exert Complementary Effects to Control Bone Quality and Mass in Mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Avec: Benoît Gobron , Béatrice Bouvard , Sagar Vyavahare , Liv Vv Blom , Kristian K Pedersen , Johanne A Windeløv , Geke A Boer , Norio Harada , Sheng Zhang , Satoko Shimazu-Kuwahara , Burton Wice , Nobuya Inagaki , Erick Legrand , Peter R Flatt , Daniel Chappard , Bolette Hartmann , Jens J Holst , Mette M Rosenkilde , Nigel Irwin , Guillaume Mabilleau

GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During

Frontiers in immunology
Avec: Stacey Bartlett , Adrian Tandhyka Gemiarto , Minh Dao Ngo , Haressh Sajiir , Semira Hailu , Roma Sinha , Cheng Xiang Foo , Léanie Kleynhans , Happy Tshivhula , Tariq Webber , Helle Bielefeldt-Ohmann , Nicholas P West , Andriette M Hiemstra , Candice E MacDonald , Liv von Voss Christensen , Larry S Schlesinger , Gerhard Walzl , Mette Marie Rosenkilde , Thomas Mandrup-Poulsen , Katharina Ronacher

The frequency of cytomegalovirus non-ELR UL146 genotypes in neonates with congenital CMV disease is comparable to strains in the background population.

BMC infectious diseases
Avec: Christian Berg , Mette M Rosenkilde , Thomas Benfield , Lene Nielsen , Thomas Sundelin , Hans R Lüttichau

Discovery of GPR183 Agonists Based on an Antagonist Scaffold.

ChemMedChem
Avec: Viktoria M S Kjaer , Loukas Ieremias , Viktorija Daugvilaite , Michael Lückmann , Thomas M Frimurer , Trond Ulven , Mette M Rosenkilde , Jon Våbenø

Selective Boosting of CCR7-Acting Chemokines; Short Peptides Boost Chemokines with Short Basic Tails, Longer Peptides Boost Chemokines with Long Basic Tails.

International journal of molecular sciences
Avec: Emma Probst Brandum , Astrid Sissel Jørgensen , Marina Barrio Calvo , Katja Spiess , Francis C Peterson , Zhang Yang , Brian F Volkman , Christopher T Veldkamp , Mette Marie Rosenkilde , Christoffer Knak Goth , Gertrud Malene Hjortø

N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 receptor selectivity towards more GLP-1 receptor interaction.

British journal of pharmacology
Avec: Maria Buur Nordskov Gabe , Laerke Smidt Gasbjerg , Sarina Gadgaard , Peter Lindquist , Jens Juul Holst , Mette Marie Rosenkilde

GPR183 Is Dispensable for B1 Cell Accumulation and Function, but Affects B2 Cell Abundance, in the Omentum and Peritoneal Cavity.

Cells
Avec: Line Barington , Liv von Voss Christensen , Kristian Kåber Pedersen , Kristine Niss Arfelt , Martin Roumain , Kristian Høj Reveles Jensen , Viktoria Madeline Skovgaard Kjær , Viktorija Daugvilaite , John F Kearney , Jan Pravsgaard Christensen , Gertrud Malene Hjortø , Giulio G Muccioli , Peter Johannes Holst , Mette Marie Rosenkilde

Chemokine N-terminal-derived peptides differentially regulate signaling by the receptors CCR1 and CCR5.

FEBS letters
Avec: Olav Larsen , Sara Schuermans , Anna Walser , Stavroula Louka , Ida Aaberg Lillethorup , Jon Våbenø , Katrine Qvortrup , Paul Proost , Mette M Rosenkilde

Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor.

Cells
Avec: Anna K O Rode , Terkild Brink Buus , Veronika Mraz , Fatima Abdul Hassan Al-Jaberi , Daniel Villalba Lopez , Shayne L Ford , Stephanie Hennen , Ina Primon Eliasen , Ib Vestergaard Klewe , Leila Gharehdaghi , Adrian Dragan , Mette M Rosenkilde , Anders Woetmann , Lone Skov , Niels Ødum , Charlotte M Bonefeld , Martin Kongsbak-Wismann , Carsten Geisler

Réseau de co-auteurs

Mette Marie Rosenkilde 25 collaborations
Jens J Holst 20 collaborations
Bolette Hartmann 18 collaborations
Jens Juul Holst 10 collaborations
Lærke S Gasbjerg 10 collaborations
Wijnand J C van der Velden 9 collaborations
Christian Berg 7 collaborations
Jon Våbenø 6 collaborations
Olav Larsen 6 collaborations
Maria Buur Nordskov Gabe 6 collaborations
Gertrud M Hjortø 5 collaborations
Hüsün S Kizilkaya 5 collaborations
Katja Spiess 5 collaborations
Viktorija Daugvilaite 5 collaborations
Signe Stensen 5 collaborations
Filip K Knop 5 collaborations
Peter Lindquist 5 collaborations
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Sarina Gadgaard 5 collaborations
Paul Proost 4 collaborations
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