Mutational Landscape of the Proglucagon-Derived Peptides.
Amino Acid Sequence
DNA Mutational Analysis
Datasets as Topic
Gene Frequency
Glucagon
/ chemistry
Glucagon-Like Peptide 1
/ chemistry
Glucagon-Like Peptide 2
/ chemistry
Glucagon-Like Peptides
/ chemistry
Humans
Models, Molecular
Mutation, Missense
Pharmacogenomic Testing
Proglucagon
/ chemistry
Protein Precursors
/ chemistry
Protein Structure, Secondary
/ genetics
GCG
GLP-1
GLP-2
GPCR
glucagon
mutant
pharmacogenomics
proglucagon
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2021
2021
Historique:
received:
21
04
2021
accepted:
24
05
2021
entrez:
5
7
2021
pubmed:
6
7
2021
medline:
16
2
2022
Statut:
epublish
Résumé
Strong efforts have been placed on understanding the physiological roles and therapeutic potential of the proglucagon peptide hormones including glucagon, GLP-1 and GLP-2. However, little is known about the extent and magnitude of variability in the amino acid composition of the proglucagon precursor and its mature peptides. Here, we identified 184 unique missense variants in the human proglucagon gene
Identifiants
pubmed: 34220721
doi: 10.3389/fendo.2021.698511
pmc: PMC8248487
doi:
Substances chimiques
Glucagon-Like Peptide 2
0
Protein Precursors
0
Proglucagon
55963-74-1
Glucagon-Like Peptides
62340-29-8
Glucagon-Like Peptide 1
89750-14-1
Glucagon
9007-92-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
698511Informations de copyright
Copyright © 2021 Lindquist, Madsen, Bräuner-Osborne, Rosenkilde and Hauser.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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