Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice.

Male Humans Azoospermia / complications Penetrance Semen Infertility, Male / metabolism Epididymis / metabolism
GPR125 Wnt signaling adhesion G protein-coupled receptor ejaculatory duct ejaculatory duct obstruction estrogen infertility seminal vesicles

Journal

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484

Informations de publication

Date de publication:
02 2023
Historique:
revised: 30 12 2022
received: 19 05 2022
accepted: 09 01 2023
entrez: 23 1 2023
pubmed: 24 1 2023
medline: 26 1 2023
Statut: ppublish

Résumé

The adhesion receptor ADGRA3 (GPR125) is a known spermatogonial stem cell marker, but its impact on male reproduction and fertility has not been examined. Using a mouse model lacking Adgra3 (Adgra3

Identifiants

DOI: 10.1096/fj.202200762RR PMID: 36688818 PMC: PMC10107928
pubmed: 36688818
doi: 10.1096/fj.202200762RR
pmc: PMC10107928
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e22781

Subventions

Organisme : European Research Council, ERC
ID : 682549
Organisme : Lundbeck Foundation
ID : R268-2017-409
Organisme : Novo Nordisk Foundation
ID : NNF20OC0059475
Organisme : Novo Nordisk Foundation
ID : NNF17OC0029222
Organisme : Valter Alex Torbjørn Eichmuller
ID : 2020-117043
Organisme : Kirsten and Freddy Johansens Foundation
ID : 2017-112697
Organisme : Dansk Frie Forskningsråd
Organisme : Department of Defense
ID : W81XWH-17-1-0013 BC160959

Informations de copyright

© 2023 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.

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Auteurs

Maja L Nybo (ML)

Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Jone M Kvam (JM)

Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

John E Nielsen (JE)

Department of Growth and Reproduction and International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.

Hanne Frederiksen (H)

Department of Growth and Reproduction and International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.

Katja Spiess (K)

Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Kristian H R Jensen (KHR)

Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Sarina Gadgaard (S)

Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Bainan Biotech, Copenhagen, Denmark.

Anna L S Walser (ALS)

Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Jesper S Thomsen (JS)

Department of Biomedicine, Aarhus University, Aarhus, Denmark.

Pamela Cowin (P)

Department of Cell Biology, New York University School of Medicine, New York, New York, USA.
Department of Dermatology, New York University School of Medicine, New York, New York, USA.

Anders Juul (A)

Department of Growth and Reproduction and International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Martin Blomberg Jensen (M)

Group of Skeletal, Mineral and Gonadal Endocrinology, Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Division of Bone and Mineral Research, HSDM/HMS, Harvard University, Boston, Massachusetts, USA.

Mette M Rosenkilde (MM)

Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Loss of Adgra3 causes obstructive azoospermia...
questionsmedicales.fr › Maladies urogénitales › Maladies urogénitales de l'homme › Maladies de l'appareil génital mâle › Infertilité masculine › Azoospermie › Loss of Adgra3 causes obstructive azoospermia...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Pénétrance › Loss of Adgra3 causes obstructive azoospermia...
questionsmedicales.fr › Liquides et sécrétions biologiques › Sécrétions corporelles › Sperme › Loss of Adgra3 causes obstructive azoospermia...
questionsmedicales.fr › Maladies urogénitales › Maladies urogénitales de l'homme › Maladies de l'appareil génital mâle › Infertilité masculine › Loss of Adgra3 causes obstructive azoospermia...
questionsmedicales.fr › Appareil urogénital › Système génital › Système génital de l'homme › Épididyme › Loss of Adgra3 causes obstructive azoospermia...