Selective Boosting of CCR7-Acting Chemokines; Short Peptides Boost Chemokines with Short Basic Tails, Longer Peptides Boost Chemokines with Long Basic Tails.
CCL19
CCL21
CCR7
basic peptide
biased signaling
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 Jan 2022
26 Jan 2022
Historique:
received:
29
11
2021
revised:
23
01
2022
accepted:
24
01
2022
entrez:
15
2
2022
pubmed:
16
2
2022
medline:
9
4
2022
Statut:
epublish
Résumé
The chemokine receptor CCR7 and its ligands CCL19 and CCL21 regulate the lymph node homing of dendritic cells and naïve T-cells and the following induction of a motile DC-T cell priming state. Although CCL19 and CCL21 bind CCR7 with similar affinities, CCL21 is a weak agonist compared to CCL19. Using a chimeric chemokine, CCL19
Identifiants
pubmed: 35163323
pii: ijms23031397
doi: 10.3390/ijms23031397
pmc: PMC8836243
pii:
doi:
Substances chimiques
Chemokine CCL19
0
Chemokine CCL21
0
Ligands
0
Peptides
0
Receptors, CCR7
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM097381
Pays : United States
Organisme : NIH HHS
ID : GM097381
Pays : United States
Organisme : BioInnovation Institute Novo Nordisk
ID : 0057954
Organisme : Innovation Fund Denmark
ID : 119786
Organisme : Lundbeck Foundation
ID : R322-2019-2171
Références
Cell Mol Life Sci. 2021 Nov;78(21-22):6963-6978
pubmed: 34586443
Annu Rev Immunol. 2014;32:659-702
pubmed: 24655300
Int J Oral Sci. 2014 Sep;6(3):125-32
pubmed: 25105816
Front Immunol. 2019 Sep 13;10:2156
pubmed: 31572374
Front Immunol. 2016 Dec 09;7:568
pubmed: 28018341
PLoS One. 2009 Sep 14;4(9):e6987
pubmed: 19750015
Front Immunol. 2018 Jun 18;9:1374
pubmed: 29967614
Biochem Biophys Res Commun. 2004 Nov 5;324(1):317-20
pubmed: 15465020
J Chem Inf Model. 2016 Sep 26;56(9):1808-22
pubmed: 27529431
J Biol Chem. 2004 May 28;279(22):23214-22
pubmed: 15054093
Front Immunol. 2014 Jun 23;5:277
pubmed: 25002861
Biochemistry. 2015 Jul 14;54(27):4163-6
pubmed: 26115234
Mucosal Immunol. 2014 Jan;7(1):27-37
pubmed: 23757304
Mol Syst Biol. 2018 Nov 20;14(11):e8486
pubmed: 30459171
J Leukoc Biol. 2016 Jun;99(6):869-82
pubmed: 26729814
Curr Drug Targets. 2019;20(9):938-941
pubmed: 30848200
Methods Enzymol. 2016;570:539-65
pubmed: 26921961
J Immunol. 2011 Jan 1;186(1):53-61
pubmed: 21106854
J Immunol Res. 2017;2017:3078194
pubmed: 28815185
Curr Med Chem. 2014;21(31):3594-614
pubmed: 25039782
Front Immunol. 2019 Jan 14;9:3115
pubmed: 30692994
Biochem Biophys Res Commun. 2006 Sep 29;348(3):1089-93
pubmed: 16904643
Arch Oral Biol. 1990;35(6):415-9
pubmed: 2372245
FASEB J. 2017 Nov;31(11):4946-4958
pubmed: 28751526
Immunol Cell Biol. 2016 Nov;94(10):955-963
pubmed: 27301418
Biochemistry. 2012 Jan 24;51(3):733-5
pubmed: 22221265
ACS Pharmacol Transl Sci. 2020 Mar 17;3(2):237-245
pubmed: 32296765
J Leukoc Biol. 2018 Aug;104(2):401-411
pubmed: 29768676
Front Immunol. 2018 Jul 16;9:1643
pubmed: 30061897
Science. 2016 Jan 8;351(6269):186-90
pubmed: 26657283
J Biol Chem. 2019 Mar 8;294(10):3464-3475
pubmed: 30567735
J Biol Chem. 1998 Mar 20;273(12):7118-22
pubmed: 9507024
J Biol Chem. 1988 Jun 5;263(16):7472-7
pubmed: 3286634
J Immunol. 2009 Jun 1;182(11):6851-60
pubmed: 19454681
J Exp Med. 1998 Jul 20;188(2):373-86
pubmed: 9670049
Immunity. 2010 May 28;32(5):703-13
pubmed: 20471289
Nat Biotechnol. 2015 Aug;33(8):842-4
pubmed: 26192319
Biochem Pharmacol. 2016 Aug 15;114:53-68
pubmed: 27106080
Biochemistry. 2020 Apr 7;59(13):1338-1350
pubmed: 32182428
Cytotherapy. 2016 Sep;18(9):1187-96
pubmed: 27424146
Nat Rev Immunol. 2011 May;11(5):355-63
pubmed: 21494268
J Dent Res. 2021 Nov;100(12):1330-1336
pubmed: 33899566