Vulnerability to stress in mouse offspring is ameliorated when pregnant dams are provided a chewing stick during prenatal stress.
Adaptation, Psychological
Animals
Corticotropin-Releasing Hormone
/ metabolism
Female
Hippocampus
/ metabolism
In Situ Hybridization
Mastication
Mice
Pregnancy
Pregnancy Complications
/ prevention & control
Prenatal Exposure Delayed Effects
RNA, Messenger
/ metabolism
Real-Time Polymerase Chain Reaction
Receptors, Glucocorticoid
/ metabolism
Receptors, Mineralocorticoid
/ metabolism
Stress, Psychological
/ prevention & control
Chewing
Corticotropin-releasing hormone
Glucocorticoid receptor
Mineralocorticoid receptor
Prenatal stress
Stress vulnerability
Journal
Archives of oral biology
ISSN: 1879-1506
Titre abrégé: Arch Oral Biol
Pays: England
ID NLM: 0116711
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
03
07
2018
revised:
14
10
2018
accepted:
15
10
2018
pubmed:
6
11
2018
medline:
20
4
2019
entrez:
4
11
2018
Statut:
ppublish
Résumé
To investigate whether maternal chewing during prenatal stress alters the responsivity of young offspring to novel stress, we examined the expression of hippocampal glucocorticoid receptors and mineralocorticoid receptors, and the levels of hypothalamic corticotropin-releasing hormone in young adult mouse offspring of dams exposed to restraint stress during pregnancy. To induce stress, the dams were placed in a ventilated restraint tube for 45 min each day from day 12 of pregnancy through parturition. While restrained in the tube, one group of dams was provided a wooden stick for chewing. Hippocampal expression of glucocorticoid receptor and mineralocorticoid receptor messenger ribonucleic acid was assessed in 1-month-old pups. Hypothalamic expression of corticotropin-releasing hormone messenger ribonucleic acid was examined before and after exposing the offspring to a novel stressor. Prenatal stress significantly decreased hippocampal expression of both glucocorticoid receptor and mineralocorticoid receptor messenger ribonucleic acid in the offspring, and increased the expression of corticotropin-releasing hormone messenger ribonucleic acid in the hypothalamic paraventricular nucleus in the offspring after novel stress exposure. Maternal chewing during exposure to prenatal stress attenuated the decreased hippocampal expression of both glucocorticoid receptor and mineralocorticoid receptor messenger ribonucleic acid, and the increased corticotropin-releasing hormone messenger ribonucleic acid expression in the hypothalamic paraventricular nucleus in the offspring. Downregulation of hippocampal glucocorticoid receptor and mineralocorticoid receptor expression in offspring due to prenatal stress, which may be associated with increased susceptibility to novel stress in adulthood, are attenuated by allowing the dams to chew on a wooden stick.
Identifiants
pubmed: 30390464
pii: S0003-9969(18)30326-1
doi: 10.1016/j.archoralbio.2018.10.014
pii:
doi:
Substances chimiques
RNA, Messenger
0
Receptors, Glucocorticoid
0
Receptors, Mineralocorticoid
0
Corticotropin-Releasing Hormone
9015-71-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
150-155Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.