Necrosulfonamide - Unexpected effect in the course of a sulfur mustard intoxication.
Acrylamides
/ pharmacology
Anti-Inflammatory Agents, Non-Steroidal
/ pharmacology
Apoptosis
/ drug effects
Cell Line
Coculture Techniques
Humans
Interleukin-6
/ metabolism
Interleukin-8
/ metabolism
Mustard Gas
/ toxicity
Necrosis
/ drug therapy
Protective Agents
/ pharmacology
Sulfonamides
/ pharmacology
Apoptosis
Interleukin
Necroptosis
Necrosis
Necrosulfonamide
Sulfur mustard
Journal
Chemico-biological interactions
ISSN: 1872-7786
Titre abrégé: Chem Biol Interact
Pays: Ireland
ID NLM: 0227276
Informations de publication
Date de publication:
25 Jan 2019
25 Jan 2019
Historique:
received:
11
06
2018
revised:
23
10
2018
accepted:
31
10
2018
pubmed:
6
11
2018
medline:
10
1
2019
entrez:
5
11
2018
Statut:
ppublish
Résumé
Although its first military use in Ypres was 100 years ago, no causal therapy for sulfur mustard (SM) intoxications exists so far. To improve the therapeutic options for the treatment of SM intoxications, we developed a co-culture of keratinocytes (HaCaT cells) and immunocompetent cells (THP-1 cells) to identify potential substances for further research. Here, we report on the influence of necrosulfonamide (NSA) on the course of a SM intoxication in vitro. The cells were challenged with 100, 200 and 300 μM SM and after 1 h treated with NSA (1, 5, 10 μM). NSA was chosen for its known ability to inhibit necroptosis, a specialized pathway of programmed necrosis. However, in our settings NSA showed only mild effects on necrotic cell death after SM intoxication, whereas it had an immense ability to prevent apoptosis. Furthermore, NSA was able to reduce the production of interleukin-6 and interleukin-8 at certain concentrations. Our data highlight NSA as a candidate compound to address cell death and inflammation in SM exposure.
Identifiants
pubmed: 30391637
pii: S0009-2797(18)30741-5
doi: 10.1016/j.cbi.2018.10.030
pii:
doi:
Substances chimiques
Acrylamides
0
Anti-Inflammatory Agents, Non-Steroidal
0
CXCL8 protein, human
0
IL6 protein, human
0
Interleukin-6
0
Interleukin-8
0
N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide
0
Protective Agents
0
Sulfonamides
0
Mustard Gas
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Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
80-85Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.