Production of Extracellular Adenosine by CD73
5'-Nucleotidase
/ immunology
Adenosine
/ metabolism
Animals
Cells, Cultured
Dendritic Cells
/ immunology
Dermatitis, Allergic Contact
/ immunology
Disease Models, Animal
Flow Cytometry
GPI-Linked Proteins
/ immunology
Immune Tolerance
/ immunology
Mice
Mice, Knockout
Random Allocation
Real-Time Polymerase Chain Reaction
/ methods
T-Lymphocytes, Regulatory
/ immunology
Journal
The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
28
06
2018
revised:
02
10
2018
accepted:
15
10
2018
pubmed:
6
11
2018
medline:
26
2
2020
entrez:
6
11
2018
Statut:
ppublish
Résumé
Dendritic cells (DCs) express the ecto-5'-nucleotidase CD73 that generates immunosuppressive adenosine (Ado) by dephosphorylation of extracellular Ado monophosphate and diphosphate. To investigate whether CD73-derived Ado has immune-suppressive activity, 2,4-dinitrothiocyanobenzene (DNTB) was applied to skin of wild-type (WT) or CD73-deficient (CD73
Identifiants
pubmed: 30393085
pii: S0022-202X(18)32708-8
doi: 10.1016/j.jid.2018.10.016
pii:
doi:
Substances chimiques
GPI-Linked Proteins
0
5'-Nucleotidase
EC 3.1.3.5
NT5E protein, human
EC 3.1.3.5
Adenosine
K72T3FS567
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
541-551Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.