Elevated expression of miR-21 and miR-155 in peripheral blood mononuclear cells as potential biomarkers for lupus nephritis.
biomarker
lupus nephritis
miR-155
miR-21
systemic lupus erythematosus
Journal
International journal of rheumatic diseases
ISSN: 1756-185X
Titre abrégé: Int J Rheum Dis
Pays: England
ID NLM: 101474930
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
03
01
2018
revised:
06
08
2018
accepted:
15
09
2018
pubmed:
7
11
2018
medline:
30
7
2019
entrez:
7
11
2018
Statut:
ppublish
Résumé
Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE). There is a great interest in using microRNAs (miRNAs) as diagnostic and prognostic biomarkers in autoimmune diseases. This study evaluated miR-16, miR-21, miR-141, miR-146a, and miR-155 expression levels in peripheral blood mononuclear cells (PBMCs) of 55 female SLE patients with absent, inactive, or active nephritis, and 30 healthy controls (HCs) using quantitative polymerase chain reaction. MiR-21 and miR-155 levels were significantly greater in the active nephritis group than in the absent, inactive or HC groups. Moreover, receiver operating characteristic and logistic regression analyses revealed miR-21 and miR-155 were significant risk factors for LN. Overexpression of miR-21 and miR-155 in PBMCs may participate in LN pathophysiology and these miRNAs could be used as biomarkers for the condition.
Identifiants
pubmed: 30398001
doi: 10.1111/1756-185X.13410
doi:
Substances chimiques
Genetic Markers
0
MIRN155 microRNA, human
0
MIRN21 microRNA, human
0
MicroRNAs
0
Types de publication
Journal Article
Langues
eng
Pagination
458-467Subventions
Organisme : Iran University of Medical Sciences
Informations de copyright
© 2018 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.