Serum R-Spondin 1 Is a New Surrogate Marker for Obesity and Insulin Resistance.
Insulin resistance
Obesity
RSPO1 protein, human
Journal
Diabetes & metabolism journal
ISSN: 2233-6079
Titre abrégé: Diabetes Metab J
Pays: Korea (South)
ID NLM: 101556588
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
18
04
2018
accepted:
22
06
2018
pubmed:
7
11
2018
medline:
7
11
2018
entrez:
7
11
2018
Statut:
ppublish
Résumé
Recent The study population consisted of 43 subjects with newly diagnosed diabetes mellitus, and 79 non-diabetic participants. Serum levels of RSPO1 were measured using the enzyme-linked immunosorbent assay. The relationships between circulating RSPO1 and diverse metabolic parameters were analyzed. Circulating RSPO1 levels increased to a greater extent in the obese group than in the lean group. Moreover, serum levels of RSPO1 were higher in the insulin-resistant group than in the insulin-sensitive group. Serum levels of RSPO1 were significantly correlated with a range of metabolic parameters including body mass index, fasting C-peptide, homeostasis model assessment of insulin resistance index, and lipid profile. Moreover, levels were significantly associated with insulin resistance and obesity in non-diabetic subjects. This study demonstrated the association between serum levels of RSPO1 and a range of metabolic parameters in humans. Serum levels of RSPO1 are significantly related to obesity and insulin resistance, although the precise mechanisms remain unknown.
Sections du résumé
BACKGROUND
Recent
METHODS
The study population consisted of 43 subjects with newly diagnosed diabetes mellitus, and 79 non-diabetic participants. Serum levels of RSPO1 were measured using the enzyme-linked immunosorbent assay. The relationships between circulating RSPO1 and diverse metabolic parameters were analyzed.
RESULTS
Circulating RSPO1 levels increased to a greater extent in the obese group than in the lean group. Moreover, serum levels of RSPO1 were higher in the insulin-resistant group than in the insulin-sensitive group. Serum levels of RSPO1 were significantly correlated with a range of metabolic parameters including body mass index, fasting C-peptide, homeostasis model assessment of insulin resistance index, and lipid profile. Moreover, levels were significantly associated with insulin resistance and obesity in non-diabetic subjects.
CONCLUSION
This study demonstrated the association between serum levels of RSPO1 and a range of metabolic parameters in humans. Serum levels of RSPO1 are significantly related to obesity and insulin resistance, although the precise mechanisms remain unknown.
Identifiants
pubmed: 30398036
pii: 42.e38
doi: 10.4093/dmj.2018.0066
pmc: PMC6581548
doi:
Substances chimiques
Biomarkers
0
RSPO1 protein, human
0
Thrombospondins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
368-376Informations de copyright
Copyright © 2019 Korean Diabetes Association.
Déclaration de conflit d'intérêts
No potential conflict of interest relevant to this article was reported.
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