Airway infection with Nontypeable Haemophilus influenzae is more rapidly eradicated in vitamin D deficient mice.
Airway infections
COPD
Cigarette smoking
NTHi
Vitamin D deficiency
Journal
The Journal of steroid biochemistry and molecular biology
ISSN: 1879-1220
Titre abrégé: J Steroid Biochem Mol Biol
Pays: England
ID NLM: 9015483
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
02
08
2018
revised:
26
10
2018
accepted:
31
10
2018
pubmed:
7
11
2018
medline:
22
5
2019
entrez:
7
11
2018
Statut:
ppublish
Résumé
Chronic obstructive pulmonary disease (COPD), which is characterized by an excessive inflammatory response of the airways, is often complicated by exacerbations. Vitamin D deficiency has been associated with an increased risk for COPD and may predispose COPD patients to a higher exacerbation rate, particularly during smoking. In the current study, we investigated the effect of vitamin D deficiency and cigarette smoke (CS)-exposure on lung inflammation and bacterial clearance after an acute infection with Nontypeable Haemophilus influenzae (NTHi). Vitamin D deficient or sufficient mice were exposed to nose-only CS or ambient air for 6 weeks and oropharyngeally instilled with 10
Identifiants
pubmed: 30399417
pii: S0960-0760(18)30454-0
doi: 10.1016/j.jsbmb.2018.10.021
pii:
doi:
Substances chimiques
Cathelicidins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
42-51Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.