Preparation and evaluation of trityl-loaded lipid nanocapsules as oxygen sensors for electron paramagnetic resonance oximetry.
Electron paramagnetic resonance
Hypoxia
Lipid nanocapsules
Nitroxide
Oximetry
Trityl
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
10 Jan 2019
10 Jan 2019
Historique:
received:
01
07
2018
revised:
08
10
2018
accepted:
02
11
2018
pubmed:
7
11
2018
medline:
4
4
2019
entrez:
7
11
2018
Statut:
ppublish
Résumé
Oxygen is essential in physiology and pathophysiology. Electron paramagnetic resonance (EPR) oximetry, using oxygen sensitive paramagnetic materials, could be attractive for measuring oxygen in tissues. The aim of the present study was to assess the properties of lipid nanocapsules (LNCs) loaded with the nitroxide tempo-benzoate (TB) or tetrathiatriarylmethyl (TAM) radicals. LNCs loaded with the EPR probes were successfully prepared by the phase inversion process leading to nanocapsules of about 60 nm. LNCs protected the TB radical against reduction in vitro. The calibration of the EPR line width (LW) as a function of the pO
Identifiants
pubmed: 30399436
pii: S0378-5173(18)30825-1
doi: 10.1016/j.ijpharm.2018.11.007
pii:
doi:
Substances chimiques
Benzoates
0
Lipids
0
Nanocapsules
0
Trityl Compounds
0
Carbon Dioxide
142M471B3J
carbogen
8063-77-2
Oxygen
S88TT14065
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
87-92Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.