Role of vitamin D and vitamin D receptor (VDR) in oral cancer.
Oral cancer
VDR
Vitamin D
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
17
09
2018
revised:
18
10
2018
accepted:
20
10
2018
pubmed:
7
11
2018
medline:
26
3
2019
entrez:
7
11
2018
Statut:
ppublish
Résumé
Oral cancer is known as one of the most common cancers, with a poor prognosis, related to delayed clinical diagnosis, either due to the lack of particular biomarkers related to the disease or costly therapeutic alternatives. Vitamin D executes its functions by interacting with the vitamin D receptor (VDR), both in healthy and diseased individuals, including oral cancer. This review discusses the role of vitamin D and VDR on tumorigenesis, emphasizing on oral cancer. Furthermore, regulation of VDR expression, mechanisms of anticancer effects of calcitriol, oral cancer chemoresistance and its relation with VDR and polymorphisms of VDR gene will be discussed. The manuscript is prepared mainly using the information collected from PubMed and MEDLINE.
Identifiants
pubmed: 30399574
pii: S0753-3322(18)36634-4
doi: 10.1016/j.biopha.2018.10.102
pii:
doi:
Substances chimiques
Calcium-Regulating Hormones and Agents
0
Receptors, Calcitriol
0
VDR protein, human
0
Vitamin D
1406-16-2
Calcitriol
FXC9231JVH
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
391-401Informations de copyright
Copyright © 2018 Elsevier Masson SAS. All rights reserved.