Genetics of response to cognitive behavior therapy in adults with major depression: a preliminary report.
Adult
Attention Deficit Disorder with Hyperactivity
Autism Spectrum Disorder
Biomarkers
Cognitive Behavioral Therapy
/ methods
Depression
/ genetics
Depressive Disorder, Major
/ genetics
Female
Humans
Male
Middle Aged
Multifactorial Inheritance
/ genetics
Preliminary Data
Prognosis
Psychiatric Status Rating Scales
Treatment Outcome
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
pubmed:
10
11
2018
medline:
4
12
2019
entrez:
10
11
2018
Statut:
ppublish
Résumé
Major depressive disorder is heritable and a leading cause of disability. Cognitive behavior therapy is an effective treatment for major depression. By quantifying genetic risk scores based on common genetic variants, the aim of this report was to explore the utility of psychiatric and cognitive trait genetic risk scores, for predicting the response of 894 adults with major depressive disorder to cognitive behavior therapy. The participants were recruited in a psychiatric setting, and the primary outcome score was measured using the Montgomery Åsberg Depression Rating Scale-Self Rated. Single-nucleotide polymorphism genotyping arrays were used to calculate the genomic risk scores based on large genetic studies of six phenotypes: major depressive disorder, bipolar disorder, attention-deficit/hyperactivity disorder, autism spectrum disorder, intelligence, and educational attainment. Linear mixed-effect models were used to test the relationships between the six genetic risk scores and cognitive behavior therapy outcome. Our analyses yielded one significant interaction effect (B = 0.09, p < 0.001): the autism spectrum disorder genetic risk score correlated with Montgomery Åsberg Depression Rating Scale-Self Rated changes during treatment, and the higher the autism spectrum disorder genetic load, the less the depressive symptoms decreased over time. The genetic risk scores for the other psychiatric and cognitive traits were not related to depressive symptom severity or change over time. Our preliminary results indicated, as expected, that the genomics of the response of patients with major depression to cognitive behavior therapy were complex and that future efforts should aim to maximize sample size and limit subject heterogeneity in order to gain a better understanding of the use of genetic risk factors to predict treatment outcome.
Identifiants
pubmed: 30410065
doi: 10.1038/s41380-018-0289-9
pii: 10.1038/s41380-018-0289-9
pmc: PMC6477793
doi:
Substances chimiques
Biomarkers
0
Types de publication
News
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
484-490Références
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