Age-dependent variation of female preponderance across different phenotypes of multiple sclerosis: A retrospective cross-sectional study.
Multiple sclerosis
aging
sex distribution
sex hormones
Journal
CNS neuroscience & therapeutics
ISSN: 1755-5949
Titre abrégé: CNS Neurosci Ther
Pays: England
ID NLM: 101473265
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
13
08
2018
revised:
15
10
2018
accepted:
15
10
2018
pubmed:
10
11
2018
medline:
12
9
2020
entrez:
10
11
2018
Statut:
ppublish
Résumé
Multiple sclerosis (MS) is an autoimmune disease of the CNS, which predominantly affects women. Studies investigating the sex distribution in MS are sparse. We aim to analyze the female-to-male ratio (F/M ratio) in different MS phenotypes in association with age at diagnosis and year of birth. We performed a retrospective cross-sectional analysis by cumulating data (sex, year of birth, age at diagnosis, and MS phenotypes) from unpublished and published studies of the participating centers. Datasets of 945 patients were collected. The overall F/M ratio was 1.9:1.0 and female preponderance was present in all phenotypes except for primary progressive MS (PPMS), in which men were predominantly affected (F/M ratio: 0.5:1.0). Female preponderance declined with increasing age at diagnosis and was no longer present in relapsing-remitting MS (RRMS) patients > 58 years of age. Our data demonstrate an age dependency of female preponderance in MS except for PPMS. This could be influenced by the lifecycle of sex hormone secretion in women. In PPMS, a male preponderance was observed in all age-groups, which might point to pathophysiological mechanisms being less influenced by sex hormones.
Identifiants
pubmed: 30411534
doi: 10.1111/cns.13083
pmc: PMC6488902
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
527-531Informations de copyright
© 2018 The Authors CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd.
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