The serotonin 2C receptor agonist WAY-163909 attenuates ketamine-induced hypothermia in mice.
5-HT
Anesthesia
Hypothermia
Ketamine
Serotonin
WAY-163909
Journal
European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354
Informations de publication
Date de publication:
05 Jan 2019
05 Jan 2019
Historique:
received:
17
08
2018
revised:
31
10
2018
accepted:
05
11
2018
pubmed:
10
11
2018
medline:
5
2
2019
entrez:
10
11
2018
Statut:
ppublish
Résumé
Anesthesia-Induced Hypothermia (AIH) has been reported to be the cause of many postoperative adverse effects, including increased mortality, decreased immune responses, cardiac events, and a greater prevalence of postoperative surgical wound infections. AIH can in some cases be minimized with pre-warming fluids and gases and forced-air heating systems, but such techniques are not always effective and can result in patient burns or other adverse effects. Stimulation of 5-HT
Identifiants
pubmed: 30412729
pii: S0014-2999(18)30651-4
doi: 10.1016/j.ejphar.2018.11.003
pmc: PMC6296880
mid: NIHMS1512865
pii:
doi:
Substances chimiques
1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta(b)(1,4)diazepino(6,7,1hj)indole
0
Azepines
0
Indoles
0
Receptor, Serotonin, 5-HT2C
0
Serotonin 5-HT2 Receptor Agonists
0
Ketamine
690G0D6V8H
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
255-261Subventions
Organisme : NIDA NIH HHS
ID : R21 DA040907
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS100512
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.
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