Seasonality in clinical courses of Kawasaki disease.
Kawasaki disease
coronary artery abnormality
refractory to high-dose intravenous immunoglobulin therapy
seasonality
Journal
Archives of disease in childhood
ISSN: 1468-2044
Titre abrégé: Arch Dis Child
Pays: England
ID NLM: 0372434
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
29
03
2018
revised:
19
07
2018
accepted:
25
10
2018
pubmed:
11
11
2018
medline:
25
2
2020
entrez:
11
11
2018
Statut:
ppublish
Résumé
Epidemics of Kawasaki disease (KD) are well known; however, the seasonal variation in the clinical course of KD is uncertain. The aim of this study was to investigate the seasonality in the clinical course of KD. This study included 744 patients who were admitted to six hospitals in Kitakyushu City for KD from 2010 to 2014. We divided the patients into two groups according to the average monthly temperature (warm and cold periods) and compared the clinical courses of KD. The clinical courses of 715 patients who were initially treated with intravenous immunoglobulin (IVIG) were investigated. The proportion of patients with resistance to the initial IVIG therapy was significantly higher during the warm period than during the cold period (p=0.016). There was no seasonality in the proportion of patients with coronary artery abnormalities. Seasonality was observed in the response to IVIG therapy of patients with KD.
Identifiants
pubmed: 30413486
pii: archdischild-2018-315267
doi: 10.1136/archdischild-2018-315267
doi:
Substances chimiques
Immunoglobulins, Intravenous
0
Immunologic Factors
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
694-696Commentaires et corrections
Type : CommentIn
Informations de copyright
© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.