TWEAK/Fn14 Interaction Confers Aggressive Properties to Cutaneous Squamous Cell Carcinoma.

Blotting, Western Carcinoma, Squamous Cell / genetics Cell Line, Tumor Cell Proliferation DNA, Neoplasm / genetics Disease Progression Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Signal Transduction Skin / metabolism Skin Neoplasms / genetics TWEAK Receptor / biosynthesis

Journal

The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720

Informations de publication

Date de publication:
04 2019
Historique:
received: 05 02 2018
revised: 08 09 2018
accepted: 27 09 2018
pubmed: 12 11 2018
medline: 3 4 2020
entrez: 12 11 2018
Statut: ppublish

Résumé

Recent studies showed that TWEAK/Fn14 signaling participates in the progression of internal malignancies. However, its role in the biological properties of cutaneous squamous cell carcinoma (SCC) remains unclear. This study was designed to explore the effect of TWEAK/Fn14 activation on cutaneous SCC as well as the relevant mechanism. The expression of TWEAK and Fn14 was determined in tissue samples of patients with cutaneous SCC. Human primary keratinocytes and SCC cell lines were cultured in vitro, receiving stimulation of TWEAK. The xenografts of SCC were generated subcutaneously in BALB/c nude mice. The results showed that both TWEAK and Fn14 were highly expressed in human cutaneous SCC. Moreover, TWEAK/Fn14 activation promoted the proliferation, migration, and invasion of cultured SCC cells. Interestingly, TNFR2 was upregulated in cultured SCC cells, and the transfection of TNFR2 small interfering RNA abrogated the effect of TWEAK on these cells. Finally, the favorable effect of TWEAK/Fn14 signals was confirmed in BALB/c nude mice with SCC xenografts. In conclusion, TWEAK/Fn14 signals contribute to the progression of cutaneous SCC, possibly involving the TNF-α-independent TNFR2 signal transduction.

Identifiants

DOI: 10.1016/j.jid.2018.09.035 PMID: 30414907
pubmed: 30414907
pii: S0022-202X(18)32795-7
doi: 10.1016/j.jid.2018.09.035
pii:
doi:

Substances chimiques

DNA, Neoplasm 0
TNFRSF12A protein, human 0
TWEAK Receptor 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

796-806

Informations de copyright

Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Guanglei Hu (G)

Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China.

Lili Liang (L)

Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China.

Yale Liu (Y)

Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China.

Jing Liu (J)

Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China.

Xuanfeng Tan (X)

Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China.

Meifeng Xu (M)

Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China.

Lingling Peng (L)

Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China.

Siyue Zhai (S)

Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China.

Qingyan Li (Q)

Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China.

Zhaowei Chu (Z)

Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China.

Weihui Zeng (W)

Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China. Electronic address: zengwh88@126.com.

Yumin Xia (Y)

Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China. Electronic address: xiayumin1202@163.com.

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Dosage immunologique › Immunotransfert › Technique de Western › TWEAK/Fn14 Interaction Confers Aggressive...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs épidermoïdes › Carcinome épidermoïde › TWEAK/Fn14 Interaction Confers Aggressive...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › TWEAK/Fn14 Interaction Confers Aggressive...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › TWEAK/Fn14 Interaction Confers Aggressive...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN tumoral › TWEAK/Fn14 Interaction Confers Aggressive...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › TWEAK/Fn14 Interaction Confers Aggressive...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › TWEAK/Fn14 Interaction Confers Aggressive...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › TWEAK/Fn14 Interaction Confers Aggressive...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Immunohistochimie › TWEAK/Fn14 Interaction Confers Aggressive...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › TWEAK/Fn14 Interaction Confers Aggressive...
questionsmedicales.fr › Système tégumentaire › Peau › TWEAK/Fn14 Interaction Confers Aggressive...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Tumeurs cutanées › TWEAK/Fn14 Interaction Confers Aggressive...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux facteurs de nécrose tumorale › Récepteur TWEAK › TWEAK/Fn14 Interaction Confers Aggressive...