Sensorimotor network segregation declines with age and is linked to GABA and to sensorimotor performance.
Adult
Aged
Aged, 80 and over
Aging
/ physiology
Brain Mapping
/ methods
Female
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Models, Neurological
Neural Pathways
/ metabolism
Psychomotor Performance
/ physiology
Sensorimotor Cortex
/ metabolism
Young Adult
gamma-Aminobutyric Acid
/ metabolism
Aging
Dedifferentiation
GABA
Network segregation
Sensorimotor
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
01 02 2019
01 02 2019
Historique:
received:
04
07
2018
revised:
03
11
2018
accepted:
07
11
2018
pubmed:
12
11
2018
medline:
16
7
2019
entrez:
12
11
2018
Statut:
ppublish
Résumé
Aging is typically associated with declines in sensorimotor performance. Previous studies have linked some age-related behavioral declines to reductions in network segregation. For example, compared to young adults, older adults typically exhibit weaker functional connectivity within the same functional network but stronger functional connectivity between different networks. Based on previous animal studies, we hypothesized that such reductions of network segregation are linked to age-related reductions in the brain's major inhibitory transmitter, gamma aminobutyric acid (GABA). To investigate this hypothesis, we conducted graph theoretical analyses of resting state functional MRI data to measure sensorimotor network segregation in both young and old adults. We also used magnetic resonance spectroscopy to measure GABA levels in the sensorimotor cortex and collected a battery of sensorimotor behavioral measures. We report four main findings. First, relative to young adults, old adults exhibit both less segregated sensorimotor brain networks and reduced sensorimotor GABA levels. Second, less segregated networks are associated with lower GABA levels. Third, less segregated networks and lower GABA levels are associated with worse sensorimotor performance. Fourth, network segregation mediates the relationship between GABA and performance. These findings link age-related differences in network segregation to age-related differences in GABA levels and sensorimotor performance. More broadly, they suggest a neurochemical substrate of age-related dedifferentiation at the level of large-scale brain networks.
Identifiants
pubmed: 30414983
pii: S1053-8119(18)32078-0
doi: 10.1016/j.neuroimage.2018.11.008
pmc: PMC6338503
mid: NIHMS997139
pii:
doi:
Substances chimiques
gamma-Aminobutyric Acid
56-12-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
234-244Subventions
Organisme : NIA NIH HHS
ID : R01 AG050523
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG006265
Pays : United States
Informations de copyright
Copyright © 2018. Published by Elsevier Inc.
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