17-Beta Hydroxysteroid Dehydrogenase 13 Is a Hepatic Retinol Dehydrogenase Associated With Histological Features of Nonalcoholic Fatty Liver Disease.
Journal
Hepatology (Baltimore, Md.)
ISSN: 1527-3350
Titre abrégé: Hepatology
Pays: United States
ID NLM: 8302946
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
01
06
2018
accepted:
19
10
2018
pubmed:
12
11
2018
medline:
30
5
2020
entrez:
12
11
2018
Statut:
ppublish
Résumé
Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease. A single-nucleotide polymorphism (SNP), rs6834314, was associated with serum liver enzymes in the general population, presumably reflecting liver fat or injury. We studied rs6834314 and its nearest gene, 17-beta hydroxysteroid dehydrogenase 13 (HSD17B13), to identify associations with histological features of NAFLD and to characterize the functional role of HSD17B13 in NAFLD pathogenesis. The minor allele of rs6834314 was significantly associated with increased steatosis but decreased inflammation, ballooning, Mallory-Denk bodies, and liver enzyme levels in 768 adult Caucasians with biopsy-proven NAFLD and with cirrhosis in the general population. We found two plausible causative variants in the HSD17B13 gene. rs72613567, a splice-site SNP in high linkage with rs6834314 (r
Identifiants
pubmed: 30415504
doi: 10.1002/hep.30350
pmc: PMC6438737
mid: NIHMS996825
doi:
Substances chimiques
Retinoids
0
17-Hydroxysteroid Dehydrogenases
EC 1.1.-
HSD17B13 protein, human
EC 1.1.-.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1504-1519Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA012153
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK106621
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061731
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061718
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000006
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000058
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000436
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061730
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061728
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000439
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000448
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000004
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002345
Pays : United States
Organisme : Intramural NIH HHS
ID : Z99 DK999999
Pays : United States
Organisme : NIH HHS
ID : R01 DK106621
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061737
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061713
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061732
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002548
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM124915
Pays : United States
Organisme : NIH HHS
ID : R01 DK107904
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061738
Pays : United States
Organisme : NLM NIH HHS
ID : HHSN276201200017C
Pays : United States
Organisme : NCI NIH HHS
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061734
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK107904
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002319
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000423
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000100
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DK075013-13
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2018 by the American Association for the Study of Liver Diseases.
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