Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis.
Animals
Apolipoprotein A-I
/ metabolism
Atherosclerosis
/ metabolism
Biological Transport
CD4-Positive T-Lymphocytes
/ cytology
Disease Models, Animal
HEK293 Cells
Humans
Interleukin-17
/ metabolism
Lipoproteins, HDL
/ metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Protein-Lysine 6-Oxidase
/ metabolism
Psoriasis
/ metabolism
Skin
/ metabolism
Th17 immunity
artery
atherosclerosis
autoimmunity
collagen
cytokines
extracellular matrix
fibrosis
interstitial transport
skin
Journal
Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170
Informations de publication
Date de publication:
05 02 2019
05 02 2019
Historique:
received:
06
06
2018
revised:
12
07
2018
accepted:
17
10
2018
pubmed:
13
11
2018
medline:
9
4
2020
entrez:
13
11
2018
Statut:
ppublish
Résumé
Lipoproteins trapped in arteries drive atherosclerosis. Extravascular low-density lipoprotein undergoes receptor uptake, whereas high-density lipoprotein (HDL) interacts with cells to acquire cholesterol and then recirculates to plasma. We developed photoactivatable apoA-I to understand how HDL passage through tissue is regulated. We focused on skin and arteries of healthy mice versus those with psoriasis, which carries cardiovascular risk in man. Our findings suggest that psoriasis-affected skin lesions program interleukin-17-producing T cells in draining lymph nodes to home to distal skin and later to arteries. There, these cells mediate thickening of the collagenous matrix, such that larger molecules including lipoproteins become entrapped. HDL transit was rescued by depleting CD4
Identifiants
pubmed: 30415924
pii: S1550-4131(18)30638-7
doi: 10.1016/j.cmet.2018.10.006
pmc: PMC6365189
mid: NIHMS1511796
pii:
doi:
Substances chimiques
Apolipoprotein A-I
0
Interleukin-17
0
Lipoproteins, HDL
0
Protein-Lysine 6-Oxidase
EC 1.4.3.13
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
475-487.e7Subventions
Organisme : NIAID NIH HHS
ID : R37 AI049653
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL127649
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK056341
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007081
Pays : United States
Organisme : NIDDK NIH HHS
ID : DP1 DK109668
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007163
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL118206
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL112276
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.
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