Expression of tenascin C in cardiovascular lesions of Kawasaki disease.
Adolescent
Autopsy
Biomarkers
/ analysis
Biopsy
Child
Child, Preschool
Coronary Artery Disease
/ etiology
Coronary Vessels
/ chemistry
Female
Humans
Immunohistochemistry
Infant
Infant, Newborn
Male
Mucocutaneous Lymph Node Syndrome
/ complications
Myocarditis
/ metabolism
Myocardium
/ chemistry
Prognosis
Severity of Illness Index
Tenascin
/ analysis
Coronary artery
Kawasaki disease
Myocarditis
Pathology
Tenascin C
Journal
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
ISSN: 1879-1336
Titre abrégé: Cardiovasc Pathol
Pays: United States
ID NLM: 9212060
Informations de publication
Date de publication:
Historique:
received:
16
04
2018
revised:
05
10
2018
accepted:
13
10
2018
pubmed:
13
11
2018
medline:
15
3
2019
entrez:
13
11
2018
Statut:
ppublish
Résumé
To examine tenascin C (TN-C) expression in coronary artery lesions (CALs) and myocardial lesions (MLs) in Kawasaki disease (KD). Twenty-five KD autopsy cases (post-KD-onset range of 6 days to 17 years) were examined in this study. Time-course analysis based on the disease day was performed of the histological findings for the CALs and MLs, as well as the localization and intensity of expression of TN-C. TN-C expression was observed to coincide with the areas where inflammatory cell infiltration was present in both coronary arteries and myocardium during the acute stage of KD, and the intensity of its expression correlated with the degree of inflammation. Obvious TN-C expression persisted in the thickened intima and media of CALs even after Disease Day 27. However, in spite of the presence of inflammatory cell infiltration, TN-C expression became weaker in the adventitia and surrounding connective tissue. After 8 months or more, TN-C was not expressed in the vasculitis scars of most cases, but expression was observed around newly formed vessels in the thickened intima and around recanalized vessels after thrombotic occlusion. The findings suggest a correlation between the degree of inflammation and TN-C expression in the cardiovascular lesions of acute-stage Kawasaki disease.
Sections du résumé
BACKGROUND/OBJECTIVE
OBJECTIVE
To examine tenascin C (TN-C) expression in coronary artery lesions (CALs) and myocardial lesions (MLs) in Kawasaki disease (KD).
METHODS AND RESULTS
RESULTS
Twenty-five KD autopsy cases (post-KD-onset range of 6 days to 17 years) were examined in this study. Time-course analysis based on the disease day was performed of the histological findings for the CALs and MLs, as well as the localization and intensity of expression of TN-C. TN-C expression was observed to coincide with the areas where inflammatory cell infiltration was present in both coronary arteries and myocardium during the acute stage of KD, and the intensity of its expression correlated with the degree of inflammation. Obvious TN-C expression persisted in the thickened intima and media of CALs even after Disease Day 27. However, in spite of the presence of inflammatory cell infiltration, TN-C expression became weaker in the adventitia and surrounding connective tissue. After 8 months or more, TN-C was not expressed in the vasculitis scars of most cases, but expression was observed around newly formed vessels in the thickened intima and around recanalized vessels after thrombotic occlusion.
CONCLUSIONS
CONCLUSIONS
The findings suggest a correlation between the degree of inflammation and TN-C expression in the cardiovascular lesions of acute-stage Kawasaki disease.
Identifiants
pubmed: 30419479
pii: S1054-8807(18)30108-X
doi: 10.1016/j.carpath.2018.10.005
pii:
doi:
Substances chimiques
Biomarkers
0
TNC protein, human
0
Tenascin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
25-30Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.