The Association of Maternal Age With Fetal Growth and Newborn Measures: The Mumbai Maternal Nutrition Project (MMNP).
Abdomen
/ growth & development
Adolescent
Adult
Birth Weight
Child Development
Crown-Rump Length
Female
Femur
/ diagnostic imaging
Fetal Development
Fetal Growth Retardation
/ diagnostic imaging
Gestational Age
Head
/ diagnostic imaging
Humans
India
Infant, Newborn
Infant, Premature
Infant, Small for Gestational Age
Male
Maternal Age
Maternal Nutritional Physiological Phenomena
Nutritional Status
Pregnancy
Premature Birth
/ etiology
Randomized Controlled Trials as Topic
Risk Factors
Ultrasonography, Prenatal
Young Adult
India
fetal biometry
maternal age
newborn
pregnancy
ultrasound
Journal
Reproductive sciences (Thousand Oaks, Calif.)
ISSN: 1933-7205
Titre abrégé: Reprod Sci
Pays: United States
ID NLM: 101291249
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
pubmed:
14
11
2018
medline:
14
4
2020
entrez:
14
11
2018
Statut:
ppublish
Résumé
Young maternal age is associated with poorer birth outcomes, but the mechanisms are incompletely understood. Using data from a prospective cohort of pregnant women living in Mumbai slums, India, we tested whether lower maternal age was associated with adverse fetal growth. Fetal crown-rump length (CRL) was recorded at a median (interquartile range, IQR) of 10 weeks' gestation (9-10 weeks). Head circumference (HC), biparietal diameter (BPD), femur length (FL), and abdominal circumference (AC) were recorded at 19 (19-20) and 29 (28-30) weeks. Newborns were measured at a median (IQR) of 2 days (1-3 days) from delivery. Gestation was assessed using prospectively collected menstrual period dates. The sample comprised 1653 singleton fetuses without major congenital abnormalities, of whom 1360 had newborn measurements. Fetuses of younger mothers had smaller CRL (0.01 standard deviation [SD] per year of maternal age; 95% confidence interval CI: 0.00-0.02 Fetuses of younger mothers were smaller from the first trimester onward and grew slower, independently of known confounding factors.
Sections du résumé
BACKGROUND
Young maternal age is associated with poorer birth outcomes, but the mechanisms are incompletely understood. Using data from a prospective cohort of pregnant women living in Mumbai slums, India, we tested whether lower maternal age was associated with adverse fetal growth.
METHODS
Fetal crown-rump length (CRL) was recorded at a median (interquartile range, IQR) of 10 weeks' gestation (9-10 weeks). Head circumference (HC), biparietal diameter (BPD), femur length (FL), and abdominal circumference (AC) were recorded at 19 (19-20) and 29 (28-30) weeks. Newborns were measured at a median (IQR) of 2 days (1-3 days) from delivery. Gestation was assessed using prospectively collected menstrual period dates.
RESULTS
The sample comprised 1653 singleton fetuses without major congenital abnormalities, of whom 1360 had newborn measurements. Fetuses of younger mothers had smaller CRL (0.01 standard deviation [SD] per year of maternal age; 95% confidence interval CI: 0.00-0.02
CONCLUSION
Fetuses of younger mothers were smaller from the first trimester onward and grew slower, independently of known confounding factors.
Identifiants
pubmed: 30419799
doi: 10.1177/1933719118799202
pmc: PMC6637817
mid: EMS81045
pii: 10.1177/1933719118799202
doi:
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
918-927Subventions
Organisme : Medical Research Council
ID : MC_UU_12011/3
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0400519
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT074048
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U147574247
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_A620_1016
Pays : United Kingdom
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