Inhibition of Protein Secretion in
antibiotic resistance
antibiotics
drug design
secretion
signal peptidase
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
18
06
2018
accepted:
04
11
2018
pubmed:
14
11
2018
medline:
28
1
2020
entrez:
14
11
2018
Statut:
epublish
Résumé
At sufficient concentrations, antibiotics effectively eradicate many bacterial infections. However, during therapy, bacteria are unavoidably exposed to lower antibiotic concentrations, and sub-MIC exposure can result in a wide variety of other effects, including the induction of virulence, which can complicate therapy, or horizontal gene transfer (HGT), which can accelerate the spread of resistance genes. Bacterial type I signal peptidase (SPase) is an essential protein that acts at the final step of the general secretory pathway. This pathway is required for the secretion of many proteins, including many required for virulence, and the arylomycins are a class of natural product antibiotics that target SPase. Here, we investigated the consequences of exposing
Identifiants
pubmed: 30420476
pii: AAC.01253-18
doi: 10.1128/AAC.01253-18
pmc: PMC6355593
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
Membrane Proteins
0
Serine Endopeptidases
EC 3.4.21.-
type I signal peptidase
EC 3.4.21.89
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R21 AI081126
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA231991
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA211526
Pays : United States
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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