Human papillomavirus infection is not involved in esophageal verrucous carcinoma.
EGFR
Esophageal cancer
Human papillomavirus
Verrucous carcinoma
p16
p53
Journal
Human pathology
ISSN: 1532-8392
Titre abrégé: Hum Pathol
Pays: United States
ID NLM: 9421547
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
22
08
2018
revised:
16
10
2018
accepted:
16
10
2018
pubmed:
14
11
2018
medline:
26
11
2019
entrez:
14
11
2018
Statut:
ppublish
Résumé
Verrucous carcinoma of the esophagus (VCE) is a rare variant of squamous cell cancer, with a puzzling clinical, etiological, and molecular profile. The etiological involvement of human papillomavirus (HPV) in the cancer's natural history is controversial. This study considers 9 cases of VCE, focusing on patients' clinical history before surgery, histologic phenotype, immunophenotype (epidermal growth factor receptor [EGFR], E-cadherin, cyclin D1, p16, and p53 expression), HPV infection, and TP53 gene mutational status (exons 5-8). Using 3 different molecular test methods, not one of these cases of VCE featured HPV infection. The only case with synchronous nodal metastasis was characterized by a TP53 missense point mutation in association with high EGFR and low E-cadherin expression levels. In conclusion, HPV infection is probably not involved with VCE, while TP53 gene mutation, EGFR overexpression, and E-cadherin loss might fuel the tumor's proliferation and lend it a metastatic potential.
Identifiants
pubmed: 30423307
pii: S0046-8177(18)30421-0
doi: 10.1016/j.humpath.2018.10.024
pii:
doi:
Substances chimiques
Cadherins
0
TP53 protein, human
0
Tumor Suppressor Protein p53
0
ErbB Receptors
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
50-57Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.