Microsomal prostaglandin E synthase-1 is a critical factor in dopaminergic neurodegeneration in Parkinson's disease.
Adult
Aged
Aged, 80 and over
Animals
Dopaminergic Neurons
/ metabolism
Female
Humans
Male
Mice, Inbred C57BL
Mice, Knockout
Middle Aged
Oxidopamine
/ administration & dosage
Parkinson Disease
/ metabolism
Parkinsonian Disorders
/ chemically induced
Primary Cell Culture
Prostaglandin-E Synthases
/ genetics
Substantia Nigra
/ metabolism
6-hydroxydopamine
Dopamine
Lewy bodies
Microsomal prostaglandin E synthase
Neurodegeneration
Neuroinflammation
Neurotoxicity
Parkinson's disease
Prostaglandin E(2)
Journal
Neurobiology of disease
ISSN: 1095-953X
Titre abrégé: Neurobiol Dis
Pays: United States
ID NLM: 9500169
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
30
05
2018
revised:
01
11
2018
accepted:
09
11
2018
pubmed:
14
11
2018
medline:
24
12
2019
entrez:
14
11
2018
Statut:
ppublish
Résumé
Parkinson's disease (PD) is a neurodegenerative disorder of uncertain pathogenesis characterized by the loss of nigrostriatal dopaminergic neurons. Although increased production of prostaglandin E
Identifiants
pubmed: 30423474
pii: S0969-9961(18)30741-1
doi: 10.1016/j.nbd.2018.11.004
pii:
doi:
Substances chimiques
Oxidopamine
8HW4YBZ748
PTGES protein, human
EC 5.3.99.3
Prostaglandin-E Synthases
EC 5.3.99.3
Ptges protein, mouse
EC 5.3.99.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
81-92Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.