Gold is for the mistress, silver for the maid: Enhanced mechanical properties, osteoinduction and antibacterial activity due to iron doping of tricalcium phosphate bone cements.
Animals
Anti-Bacterial Agents
/ pharmacology
Bone Cements
/ pharmacology
Calcium Phosphates
/ chemistry
Cell Line
Core Binding Factor Alpha 1 Subunit
/ metabolism
Gold
/ pharmacology
Humans
Iron
/ chemistry
Kinetics
Mice
Osseointegration
/ drug effects
Osteoblasts
/ cytology
Osteocalcin
/ genetics
Powders
RNA, Messenger
/ genetics
Silver
/ pharmacology
Spectroscopy, Mossbauer
Spectrum Analysis, Raman
Temperature
X-Ray Diffraction
Bone cement
Escherichia coli
Hardening behaviour
Iron-doped tricalcium phosphate
Osteoblastic MC3T3-E1
Pseudomonas aeruginosa
Salmonella enteritidis
Staphylococcus aureus
Journal
Materials science & engineering. C, Materials for biological applications
ISSN: 1873-0191
Titre abrégé: Mater Sci Eng C Mater Biol Appl
Pays: Netherlands
ID NLM: 101484109
Informations de publication
Date de publication:
01 Jan 2019
01 Jan 2019
Historique:
received:
10
02
2018
revised:
17
09
2018
accepted:
04
10
2018
entrez:
15
11
2018
pubmed:
15
11
2018
medline:
5
2
2019
Statut:
ppublish
Résumé
Self-hardening calcium phosphate cements present ideal bone tissue substitutes from the standpoints of bioactivity and biocompatibility, yet they suffer from (a) weak mechanical properties, (b) negligible osteoinduction without the use of exogenous growth factors, and (c) a lack of intrinsic antibacterial activity. Here we attempt to improve on these deficiencies by studying the properties of self-setting Fe-doped bone-integrative cements containing two different concentrations of the dopant: 0.49 and 1.09 wt% Fe. The hardening process, which involved the transformation of Fe-doped β-tricalcium phosphate (Fe-TCP) to nanocrystalline brushite, was investigated in situ by continuously monitoring the cements using the Energy Dispersive X-Ray Diffraction technique. The setting time was 20 min and the hardening time 2 h, but it took 50 h for the cement to completely stabilize compositionally and mechanically. Still, compared to other similar systems, the phase transformation during hardening was relatively fast and it also followed a relatively simple reaction path, virtually free of complex intermediates and noisy background. Mössbauer spectrometry demonstrated that
Identifiants
pubmed: 30423766
pii: S0928-4931(18)30437-5
doi: 10.1016/j.msec.2018.10.028
pmc: PMC6366449
mid: NIHMS1509413
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bone Cements
0
Calcium Phosphates
0
Core Binding Factor Alpha 1 Subunit
0
Powders
0
RNA, Messenger
0
Osteocalcin
104982-03-8
Silver
3M4G523W1G
Gold
7440-57-5
Iron
E1UOL152H7
tricalcium phosphate
K4C08XP666
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
798-810Subventions
Organisme : NIDCR NIH HHS
ID : R00 DE021416
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.
Références
ACS Appl Mater Interfaces. 2017 Nov 15;9(45):39283-39302
pubmed: 29058880
J Control Release. 2016 Jan 10;221:37-47
pubmed: 26639177
Biomaterials. 2001 Nov;22(21):2937-45
pubmed: 11561900
Nutr Rev. 1976 May;34(5):129-32
pubmed: 177908
Int J Antimicrob Agents. 2012 Apr;39(4):295-9
pubmed: 22341298
Thyroid. 2002 Oct;12(10):867-78
pubmed: 12487769
J Mech Behav Biomed Mater. 2016 Jul;60:617-627
pubmed: 27082025
Acta Biomater. 2011 Apr;7(4):1844-52
pubmed: 21185410
J Res Med Sci. 2014 Feb;19(2):164-74
pubmed: 24778671
J Nutr. 2003 May;133(5 Suppl 1):1468S-72S
pubmed: 12730445
J R Soc Interface. 2014 Dec 6;11(101):20140727
pubmed: 25297314
Arch Dis Child. 1973 Nov;48(11):864-6
pubmed: 4761054
J Biomed Mater Res A. 2013 May;101(5):1416-26
pubmed: 23115118
J Pediatr. 1975 Jun;86(6):833-43
pubmed: 1127523
Trends Biotechnol. 2013 Oct;31(10):594-605
pubmed: 24012308
Acta Biomater. 2017 Mar 1;50:78-88
pubmed: 27965170
PLoS One. 2017 Aug 1;12(8):e0182109
pubmed: 28763481
J Funct Biomater. 2016 Apr 18;7(2):
pubmed: 27096874
Bone. 2011 Jun 1;48(6):1282-90
pubmed: 21419884
J Mater Sci Mater Med. 2015 Mar;26(3):130
pubmed: 25693675
Am J Clin Nutr. 1979 Apr;32(4):916-25
pubmed: 107787
Acta Biomater. 2014 Mar;10(3):1035-49
pubmed: 24231047
Neurosurgery. 2001 Mar;48(3):616-24; discussion 624-5
pubmed: 11270553
ACS Appl Mater Interfaces. 2016 Mar;8(12):7691-708
pubmed: 26958867
Ciba Found Symp. 1976 Dec 7-9;(51):249-68
pubmed: 1052033
J Biol Chem. 1977 Dec 10;252(23):8440-5
pubmed: 925004
J Pediatr. 1975 Jun;86(6):899-902
pubmed: 1127529
J Mater Sci Mater Med. 2017 Aug;28(8):117
pubmed: 28681217
Pharmacol Ther. 2012 Feb;133(2):177-88
pubmed: 22115751
Nucleic Acids Res. 2001 May 1;29(9):e45
pubmed: 11328886
Br J Haematol. 1969 Jan-Feb;16(1):1-4
pubmed: 5795211
Met Ions Life Sci. 2013;12:241-78
pubmed: 23595675
Eur J Clin Nutr. 1997 Jan;51 Suppl 1:S4-8
pubmed: 9023471
J Prosthodont. 2006 Sep-Oct;15(5):321-8
pubmed: 16958734
J Mater Chem B. 2013 Feb 21;1(7):958-969
pubmed: 32262360
J Biomed Mater Res B Appl Biomater. 2010 Aug;94(2):414-420
pubmed: 20574977
J Mater Chem B. 2017 Apr 21;5(15):2775-2787
pubmed: 32264164
Mater Sci Eng C Mater Biol Appl. 2017 Oct 1;79:270-279
pubmed: 28629018
Prog Biomater. 2016;5:9-70
pubmed: 27471662
Br Med J. 1980 May 24;280(6226):1249-51
pubmed: 7388490