Phosphomimetic-mediated in vitro rescue of hypertrophic cardiomyopathy linked to R58Q mutation in myosin regulatory light chain.


Journal

The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646

Informations de publication

Date de publication:
01 2019
Historique:
received: 05 07 2018
revised: 03 10 2018
accepted: 13 11 2018
pubmed: 16 11 2018
medline: 10 7 2019
entrez: 16 11 2018
Statut: ppublish

Résumé

Myosin regulatory light chain (RLC) phosphorylation is important for cardiac muscle mechanics/function as well as for the Ca

Identifiants

pubmed: 30430732
doi: 10.1111/febs.14702
pmc: PMC6326841
mid: NIHMS997858
doi:

Substances chimiques

Actins 0
Myosin Light Chains 0
Calcium SY7Q814VUP

Banques de données

PDB
['3jvtB', '2w4aA', '1prwA', '2mysB', '4mvfA', '4agrA', '4ik1A']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

151-168

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL071778
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL123255
Pays : United States
Organisme : NIH HHS
ID : HL123255
Pays : United States
Organisme : American Heart Association
ID : 17PRE33650085
Pays : International

Informations de copyright

© 2018 Federation of European Biochemical Societies.

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Auteurs

Sunil Yadav (S)

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, FL, USA.

Katarzyna Kazmierczak (K)

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, FL, USA.

Jingsheng Liang (J)

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, FL, USA.

Yoel H Sitbon (YH)

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, FL, USA.

Danuta Szczesna-Cordary (D)

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, FL, USA.

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Classifications MeSH