Involvement of the long noncoding RNA NEAT1 in carcinogenesis.
NEAT1
cancer
ceRNA
lncRNA
miRNA
Journal
Molecular oncology
ISSN: 1878-0261
Titre abrégé: Mol Oncol
Pays: United States
ID NLM: 101308230
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
25
07
2018
revised:
25
10
2018
accepted:
07
11
2018
pubmed:
16
11
2018
medline:
20
11
2019
entrez:
16
11
2018
Statut:
ppublish
Résumé
Altered expression levels of the long noncoding RNA (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1) have been reported in different types of cancer. More than half of the NEAT1 studies in cancer have been published within the last 2 years. In this review, we discuss very recent developments and insights into NEAT1 contribution to carcinogenesis. Summarizing the literature, it becomes obvious that NEAT1 is a lncRNA highly de-/upregulated in a variety of cancer entities, in which it primarily acts as a competing endogenous RNA (ceRNA) which sponges tumor-suppressive microRNA (miRNA). The sponged miRNA lose their ability to degrade, silence, or hamper translation of their downstream-mostly oncogenic-target transcripts, ultimately promoting carcinogenesis. This role of NEAT1 function in tumorigenesis suggests it may be a prognostic biomarker as well as potential therapeutic target, pending the completion of further studies into the underlying mechanisms.
Identifiants
pubmed: 30430751
doi: 10.1002/1878-0261.12404
pmc: PMC6322192
doi:
Substances chimiques
Biomarkers, Tumor
0
MicroRNAs
0
NEAT1 long non-coding RNA, human
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
46-60Informations de copyright
© 2018 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.
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