Eomesodermin controls a unique differentiation program in human IL-10 and IFN-γ coproducing regulatory T cells.
Animals
Cell Differentiation
Cell Lineage
Cells, Cultured
Gene Expression Regulation
Graft vs Host Disease
/ immunology
Granzymes
/ metabolism
Humans
Immunologic Memory
Inflammatory Bowel Diseases
/ immunology
Interferon-gamma
/ metabolism
Interleukin-10
/ metabolism
Mice
T-Box Domain Proteins
/ genetics
T-Lymphocyte Subsets
/ immunology
T-Lymphocytes, Regulatory
/ immunology
Th1 Cells
/ immunology
Differentiation
EOMES
Granzyme K
Regulatory T cells
Th17
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
28
05
2018
revised:
28
09
2018
accepted:
09
11
2018
pubmed:
16
11
2018
medline:
29
5
2019
entrez:
16
11
2018
Statut:
ppublish
Résumé
Whether human IL-10-producing regulatory T cells ("Tr1") represent a distinct differentiation lineage or an unstable activation stage remains a key unsolved issue. Here, we report that Eomesodermin (Eomes) acted as a lineage-defining transcription factor in human IFN-γ/IL-10 coproducing Tr1-like cells. In vivo occurring Tr1-like cells expressed Eomes, and were clearly distinct from all other CD4
Identifiants
pubmed: 30431161
doi: 10.1002/eji.201847722
doi:
Substances chimiques
EOMES protein, human
0
T-Box Domain Proteins
0
Interleukin-10
130068-27-8
Interferon-gamma
82115-62-6
Granzymes
EC 3.4.21.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
96-111Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.