Bioequivalence Comparison of Pediatric Dasatinib Formulations and Elucidation of Absorption Mechanisms Through Integrated PBPK Modeling.

Administration, Oral Area Under Curve Biological Availability Chemistry, Pharmaceutical / methods Child Dasatinib / pharmacokinetics Drug Compounding / methods Drug Liberation Humans Solubility Suspensions / pharmacokinetics Tablets / pharmacokinetics Therapeutic Equivalency
absorption bioequivalence biopharmaceutical characterization formulation gastroPlus modeling in silico modeling intestinal absorption physiologically based pharmacokinetic (PBPK) modeling special populations

Journal

Journal of pharmaceutical sciences
ISSN: 1520-6017
Titre abrégé: J Pharm Sci
Pays: United States
ID NLM: 2985195R

Informations de publication

Date de publication:
Jan 2019
Historique:
received: 24 08 2018
revised: 31 10 2018
accepted: 01 11 2018
pubmed: 16 11 2018
medline: 20 2 2020
entrez: 16 11 2018
Statut: ppublish

Résumé

SPRYCEL

Identifiants

DOI: 10.1016/j.xphs.2018.11.005 PMID: 30439460
pubmed: 30439460
pii: S0022-3549(18)30706-8
doi: 10.1016/j.xphs.2018.11.005
pii:
doi:

Substances chimiques

Suspensions 0
Tablets 0
Dasatinib RBZ1571X5H

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

741-749

Informations de copyright

Copyright © 2019 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Auteurs

Shruthi Vaidhyanathan (S)

Drug Product Science and Technology, Bristol-Myers Squibb, New Brunswick, New Jersey 08901.

Xiaoning Wang (X)

Clinical Pharmacology and Pharmacometrics, Bristol-Myers Squibb, Lawrenceville, New Jersey 08648.

John Crison (J)

Drug Product Science and Technology, Bristol-Myers Squibb, New Brunswick, New Jersey 08901.

Sailesh Varia (S)

Biopharmaceutics R&D, Bristol-Myers Squibb, New Brunswick, New Jersey 08901.

Julia Z H Gao (JZH)

Biopharmaceutics R&D, Bristol-Myers Squibb, New Brunswick, New Jersey 08901.

Ajay Saxena (A)

Biopharmaceutics, Biocon Bristol-Myers Squibb R&D Centre (BBRC), Bangalore, India.

David Good (D)

Drug Product Science and Technology, Bristol-Myers Squibb, New Brunswick, New Jersey 08901. Electronic address: DAVID.GOOD2@bms.com.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie orale › Bioequivalence Comparison of Pediatric...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Aire sous la courbe › Bioequivalence Comparison of Pediatric...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biodisponibilité › Bioequivalence Comparison of Pediatric...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Chimie pharmaceutique › Bioequivalence Comparison of Pediatric...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Bioequivalence Comparison of Pediatric...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Dasatinib › Bioequivalence Comparison of Pediatric...
questionsmedicales.fr › Techniques d'investigation › Préparation de médicament › Bioequivalence Comparison of Pediatric...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Libération de médicament › Bioequivalence Comparison of Pediatric...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Bioequivalence Comparison of Pediatric...
questionsmedicales.fr › Phénomènes chimiques › Solubilité › Bioequivalence Comparison of Pediatric...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Suspensions › Bioequivalence Comparison of Pediatric...
questionsmedicales.fr › Préparations pharmaceutiques › Comprimés › Bioequivalence Comparison of Pediatric...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Équivalence thérapeutique › Bioequivalence Comparison of Pediatric...