Agomelatine modulates calcium signaling through protein kinase C and phospholipase C-mediated mechanisms in rat sensory neurons.
Acetamides
/ pharmacology
Animals
Benzophenanthridines
/ pharmacology
Calcium
/ metabolism
Calcium Signaling
/ drug effects
Cells, Cultured
Ganglia, Spinal
/ drug effects
Humans
Protein Kinase C
/ antagonists & inhibitors
Rats
Receptors, Melatonin
/ antagonists & inhibitors
Sensory Receptor Cells
/ drug effects
Tryptamines
/ pharmacology
Type C Phospholipases
/ antagonists & inhibitors
agomelatine
antidepressant
calcium signaling
nociception
sensory neurons
Journal
Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
28
09
2018
accepted:
22
10
2018
pubmed:
18
11
2018
medline:
12
5
2020
entrez:
17
11
2018
Statut:
ppublish
Résumé
Agomelatine, a novel antidepressant exerting its effects through melatonergic and serotonergic systems, implicated to be effective against pain including neuropathic pain but without any knowledge of mechanism of action. To explore the possible role of agomelatine on nociceptive transmission at the peripheral level, the effects of agomelatine on intracellular calcium ([Ca
Substances chimiques
Acetamides
0
Benzophenanthridines
0
Receptors, Melatonin
0
Tryptamines
0
luzindole
117946-91-5
agomelatine
137R1N49AD
chelerythrine
E3B045W6X0
Protein Kinase C
EC 2.7.11.13
Type C Phospholipases
EC 3.1.4.-
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10741-10746Informations de copyright
© 2018 Wiley Periodicals, Inc.