Identification and regulation of the long non-coding RNA Heat2 in heart failure.
Eosinophils
Heart failure
Immune cells
lncRNAs
Journal
Journal of molecular and cellular cardiology
ISSN: 1095-8584
Titre abrégé: J Mol Cell Cardiol
Pays: England
ID NLM: 0262322
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
03
07
2018
revised:
03
09
2018
accepted:
08
11
2018
pubmed:
18
11
2018
medline:
10
1
2020
entrez:
17
11
2018
Statut:
ppublish
Résumé
Circulating immune cells have a significant impact on progression and outcome of heart failure. Long non-coding RNAs (lncRNAs) comprise novel epigenetic regulators which control cardiovascular diseases and inflammatory disorders. We aimed to identify lncRNAs regulated in circulating immune cells of the blood of heart failure patients. Next-generation sequencing revealed 110 potentially non-coding RNA transcripts differentially expressed in peripheral blood mononuclear cells of heart failure patients with reduced ejection fraction. The up-regulated lncRNA Heat2 was further functionally characterized. Heat2 expression was detected in whole blood, PBMNCs, eosinophil and basophil granulocytes. Heat2 regulates cell division, invasion, transmigration and immune cell adhesion on endothelial cells. Heat2 is an immune cell enriched lncRNA that is elevated in the blood of heart failure patients and controls cellular functions.
Identifiants
pubmed: 30445017
pii: S0022-2828(18)30386-9
doi: 10.1016/j.yjmcc.2018.11.004
pii:
doi:
Substances chimiques
RNA, Long Noncoding
0
RNA, Messenger
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13-22Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.