Can the discriminative stimulus effects of nicotine function concurrently as modulatory opponents in operant and pavlovian occasion setting paradigms in rats?
Bidirectional conditioning
Drug discrimination
Feature negative
Feature positive
Interoception
Nicotine
Occasion setting
Rats
S(D)
S(Δ)
Journal
Behavioural processes
ISSN: 1872-8308
Titre abrégé: Behav Processes
Pays: Netherlands
ID NLM: 7703854
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
23
07
2018
revised:
09
11
2018
accepted:
09
11
2018
pubmed:
18
11
2018
medline:
23
2
2019
entrez:
17
11
2018
Statut:
ppublish
Résumé
Nicotine promotes interoceptive changes in the nervous system. Such interoceptive stimuli play important roles in modulating addictive behavior. Operant and Pavlovian stimulus control modulate responsiveness to environmental stimuli related to drug-seeking and self-administration. Nicotine functions as a discriminative stimulus in modulating operant behavior as well as Pavlovian feature stimuli in modulating the conditional responding (CR) to exteroceptive CS→US contingencies. Elucidation of the interaction of these interoceptive stimulus control functions is vital for a comprehensive understanding of nicotine use/abuse, which might lead to better behavioral treatment strategies. This experiment evaluated the interaction among Pavlovian feature positive (FP) and feature negative (FN) effects of nicotine on concurrently occurring operant S
Identifiants
pubmed: 30445119
pii: S0376-6357(18)30310-3
doi: 10.1016/j.beproc.2018.11.004
pmc: PMC6309749
mid: NIHMS1515235
pii:
doi:
Substances chimiques
Nicotinic Agonists
0
Nicotine
6M3C89ZY6R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
144-150Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103506
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.
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