Comparative immuno-Cerenkov luminescence and -PET imaging enables detection of PSMA
Acetates
Animals
Antibodies, Monoclonal
/ pharmacokinetics
Antigens, Surface
/ metabolism
Cell Line, Tumor
Copper Radioisotopes
/ pharmacokinetics
Glutamate Carboxypeptidase II
/ metabolism
Heterocyclic Compounds, 1-Ring
Heterografts
Humans
Immunoconjugates
/ pharmacokinetics
Luminescent Measurements
/ methods
Male
Mice
Mice, SCID
Positron-Emission Tomography
/ methods
Prostatic Neoplasms
/ diagnostic imaging
3/F11
C4-2 prostate tumor
DU 145 prostate tumor
Immuno-Cerenkov luminescence imaging
Monoclonal antibody
PSMA
Prostate cancer
Journal
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
ISSN: 1872-9800
Titre abrégé: Appl Radiat Isot
Pays: England
ID NLM: 9306253
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
25
01
2018
revised:
12
07
2018
accepted:
07
09
2018
pubmed:
18
11
2018
medline:
10
4
2019
entrez:
17
11
2018
Statut:
ppublish
Résumé
Here, we describe immuno-Cerenkov luminescence imaging (immuno-CLI) with a specific monoclonal antibody-based tracer for the detection of prostate tumors, which is used in preclinical positron emission tomography (PET) imaging. As PET isotopes generate a continuous spectrum of light in the ultraviolet/visible (UV/vis) wavelength range (Cerenkov luminescence, CL) in dielectric materials and consequently inside living tissues, these isotopes can also be detected by luminescence imaging performed with optical imaging (OI) systems. Imaging tumors with tracers that are specifically binding to a tumor-associated antigen can increase diagnostic accuracy, enables monitoring of treatment efficacy, and can be advantageous compared to radiolabeled small molecules used in PET-oncology such as 2-deoxy-2-[
Identifiants
pubmed: 30445280
pii: S0969-8043(18)30091-5
doi: 10.1016/j.apradiso.2018.09.006
pii:
doi:
Substances chimiques
1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane
0
Acetates
0
Antibodies, Monoclonal
0
Antigens, Surface
0
Copper Radioisotopes
0
Copper-64
0
Heterocyclic Compounds, 1-Ring
0
Immunoconjugates
0
FOLH1 protein, human
EC 3.4.17.21
Glutamate Carboxypeptidase II
EC 3.4.17.21
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
149-155Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.